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Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
A. Tin, J. Marten, VL. Halperin Kuhns, Y. Li, M. Wuttke, H. Kirsten, KB. Sieber, C. Qiu, M. Gorski, Z. Yu, A. Giri, G. Sveinbjornsson, M. Li, AY. Chu, A. Hoppmann, LJ. O'Connor, B. Prins, T. Nutile, D. Noce, M. Akiyama, M. Cocca, S. Ghasemi, PJ....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc20005835
Grantová podpora
MC_UU_00007/10
Medical Research Council - United Kingdom
RG/18/13/33946
British Heart Foundation - United Kingdom
RG/13/13/30194
British Heart Foundation - United Kingdom
P30 DK090868
NIDDK NIH HHS - United States
R01 AR073178
NIAMS NIH HHS - United States
T32 HL129982
NHLBI NIH HHS - United States
R01 DK114091
NIDDK NIH HHS - United States
MC_QA137853
Medical Research Council - United Kingdom
MC_PC_17228
Medical Research Council - United Kingdom
P30 DK116074
NIDDK NIH HHS - United States
Online
Plný text
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- ABC transportér z rodiny G, člen 2 genetika MeSH
- celogenomová asociační studie MeSH
- dna (nemoc) krev epidemiologie genetika MeSH
- genetická predispozice k nemoci MeSH
- genetické lokusy MeSH
- genetické markery * MeSH
- hepatocytární jaderný faktor 1-alfa genetika MeSH
- hepatocytární jaderný faktor 4 genetika MeSH
- játra metabolismus patologie MeSH
- jednonukleotidový polymorfismus * MeSH
- kardiovaskulární nemoci krev epidemiologie genetika MeSH
- kohortové studie MeSH
- kyselina močová krev MeSH
- ledviny metabolismus patologie MeSH
- lidé MeSH
- metabolické nemoci krev epidemiologie genetika MeSH
- nádorové proteiny genetika MeSH
- orgánová specificita MeSH
- signální transdukce * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.
5th Department of Medicine Medical Faculty Mannheim University of Heidelberg Mannheim Germany
Cardiology Geneva University Hospitals Geneva Switzerland
Center for Primary Care and Public Health University of Lausanne Lausanne Switzerland
Clinical Division of Neurogeriatrics Department of Neurology Medical University of Graz Graz Austria
Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN USA
Department of Biostatistics Boston University School of Public Health Boston MA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Clinical Biochemistry Landspitali University Hospital Reykjavik Iceland
Department of Clinical Epidemiology Leiden University Medical Centre Leiden the Netherlands
Department of Endocrinology and Nephrology University of Leipzig Leipzig Germany
Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Genetic Epidemiology University of Regensburg Regensburg Germany
Department of Genetics University of North Carolina Chapel Hill NC USA
Department of Medicine and Genetics University of Pennsylvania Philadelphia PA USA
Department of Nephrology University Hospital Regensburg Regensburg Germany
Department of Physiology and Biophysics University of Mississippi Medical Centre Jackson MS USA
Department of Physiology University of Maryland School of Medicine Baltimore MD USA
Department of Psychiatry University Hospital of Lausanne Lausanne Switzerland
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Division of Endocrinology Nephrology and Rheumatology University of Leipzig Leipzig Germany
eCODE Genetics Amgen Inc Reykjavik Iceland
Epidemiology Harvard T H Chan School of Public Health Boston MA USA
Estonian Genome Centre Institute of Genomics University of Tartu Tartu Estonia
Eurac Research Institute for Biomedicine Bolzano Italy
Faculty of Medicine School of Health Sciences University of Iceland Reykjavik Iceland
Faculty of Medicine University of Split Split Croatia Gen info Ltd Zagreb Croatia
Geisinger Research Biomedical and Translational Informatics Institute Danville PA USA
Geisinger Research Biomedical and Translational Informatics Institute Rockville MD USA
Genetics Merck and Co Inc Kenilworth NJ USA
Human Genetics Centre University of Texas Health Science Centre Houston TX USA
Institute for Maternal and Child Health IRCCS Burlo Garofolo Trieste Italy
Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK
Institute of Genetics and Biophysics Adriano Buzzati Traverso CNR Naples Italy
Institute of Molecular Genetics National Research Council of Italy Pavia Italy
Institute of Physiology University Medicine Greifswald Karlsburg Germany
Institute of Physiology University of Zurich Zurich Switzerland
Integrated Research and Treatment Centre Adiposity Diseases University of Leipzig Leipzig Germany
Internal Medicine Department of Medicine Lausanne University Hospital Lausanne Switzerland
Landspitalinn University Hospital Reykjavík Iceland University of Iceland Reykjavík Iceland
LIFE Research Centre for Civilization Diseases University of Leipzig Leipzig Germany
QIMR Berghofer Medical Research Institute Brisbane Queensland Australia
RIKEN Centre for Integrative Medical Sciences Yokohama Japan
San Raffaele Research Institute Milano Italy
Strangeways Research Laboratory University of Cambridge Cambridge UK
Target Sciences Genetics GlaxoSmithKline Collegeville PA USA
University of Maryland School of Medicine Baltimore MD USA
University of Queensland St Lucia Queensland Australia
University of Trieste Department of Medicine Surgery and Health Sciences Trieste Italy
Vanderbilt University Medical Centre Division of Nephrology and Hypertension Nashville TN USA
Citace poskytuje Crossref.org
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- $a Tin, Adrienne $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. atin1@jhu.edu. Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. atin1@jhu.edu.
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- $a Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels / $c A. Tin, J. Marten, VL. Halperin Kuhns, Y. Li, M. Wuttke, H. Kirsten, KB. Sieber, C. Qiu, M. Gorski, Z. Yu, A. Giri, G. Sveinbjornsson, M. Li, AY. Chu, A. Hoppmann, LJ. O'Connor, B. Prins, T. Nutile, D. Noce, M. Akiyama, M. Cocca, S. Ghasemi, PJ. van der Most, K. Horn, Y. Xu, C. Fuchsberger, S. Sedaghat, S. Afaq, N. Amin, J. Ärnlöv, SJL. Bakker, N. Bansal, D. Baptista, S. Bergmann, ML. Biggs, G. Biino, E. Boerwinkle, EP. Bottinger, TS. Boutin, M. Brumat, R. Burkhardt, E. Campana, A. Campbell, H. Campbell, RJ. Carroll, E. Catamo, JC. Chambers, M. Ciullo, MP. Concas, J. Coresh, T. Corre, D. Cusi, SC. Felicita, MH. de Borst, A. De Grandi, R. de Mutsert, APJ. de Vries, G. Delgado, A. Demirkan, O. Devuyst, K. Dittrich, KU. Eckardt, G. Ehret, K. Endlich, MK. Evans, RT. Gansevoort, P. Gasparini, V. Giedraitis, C. Gieger, G. Girotto, M. Gögele, SD. Gordon, DF. Gudbjartsson, V. Gudnason, German Chronic Kidney Disease Study, T. Haller, P. Hamet, TB. Harris, C. Hayward, AA. Hicks, E. Hofer, H. Holm, W. Huang, N. Hutri-Kähönen, SJ. Hwang, MA. Ikram, RM. Lewis, E. Ingelsson, J. Jakobsdottir, I. Jonsdottir, H. Jonsson, PK. Joshi, NS. Josyula, B. Jung, M. Kähönen, Y. Kamatani, M. Kanai, SM. Kerr, W. Kiess, ME. Kleber, W. Koenig, JS. Kooner, A. Körner, P. Kovacs, BK. Krämer, F. Kronenberg, M. Kubo, B. Kühnel, M. La Bianca, LA. Lange, B. Lehne, T. Lehtimäki, Lifelines Cohort Study, J. Liu, M. Loeffler, RJF. Loos, LP. Lyytikäinen, R. Magi, A. Mahajan, NG. Martin, W. März, D. Mascalzoni, K. Matsuda, C. Meisinger, T. Meitinger, A. Metspalu, Y. Milaneschi, V. A. Million Veteran Program, CJ. O'Donnell, OD. Wilson, JM. Gaziano, PP. Mishra, KL. Mohlke, N. Mononen, GW. Montgomery, DO. Mook-Kanamori, M. Müller-Nurasyid, GN. Nadkarni, MA. Nalls, M. Nauck, K. Nikus, B. Ning, IM. Nolte, R. Noordam, JR. O'Connell, I. Olafsson, S. Padmanabhan, BWJH. Penninx, T. Perls, A. Peters, M. Pirastu, N. Pirastu, G. Pistis, O. Polasek, B. Ponte, DJ. Porteous, T. Poulain, MH. Preuss, TJ. Rabelink, LM. Raffield, OT. Raitakari, R. Rettig, M. Rheinberger, KM. Rice, F. Rizzi, A. Robino, I. Rudan, A. Krajcoviechova, R. Cifkova, R. Rueedi, D. Ruggiero, KA. Ryan, Y. Saba, E. Salvi, H. Schmidt, R. Schmidt, CM. Shaffer, AV. Smith, BH. Smith, CN. Spracklen, K. Strauch, M. Stumvoll, P. Sulem, SM. Tajuddin, A. Teren, J. Thiery, CHL. Thio, U. Thorsteinsdottir, D. Toniolo, A. Tönjes, J. Tremblay, AG. Uitterlinden, S. Vaccargiu, P. van der Harst, CM. van Duijn, N. Verweij, U. Völker, P. Vollenweider, G. Waeber, M. Waldenberger, JB. Whitfield, SH. Wild, JF. Wilson, Q. Yang, W. Zhang, AB. Zonderman, M. Bochud, JG. Wilson, SA. Pendergrass, K. Ho, A. Parsa, PP. Pramstaller, BM. Psaty, CA. Böger, H. Snieder, AS. Butterworth, Y. Okada, TL. Edwards, K. Stefansson, K. Susztak, M. Scholz, IM. Heid, AM. Hung, A. Teumer, C. Pattaro, OM. Woodward, V. Vitart, A. Köttgen,
- 520 9_
- $a Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.
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- 650 _2
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- 700 1_
- $a Halperin Kuhns, Victoria L $u Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Gorski, Mathias $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Hayward, Caroline $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Hicks, Andrew A $u Eurac Research, Institute for Biomedicine, Bolzano, Italy.
- 700 1_
- $a Hofer, Edith $u Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
- 700 1_
- $a Holm, Hilma $u deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
- 700 1_
- $a Huang, Wei $u Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centre, Shanghai, China. Shanghai Industrial Technology Institute, Shanghai, China.
- 700 1_
- $a Hutri-Kähönen, Nina $u Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Hwang, Shih-Jen $u National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA. The Centre for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA.
- 700 1_
- $a Ikram, M Arfan $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
- 700 1_
- $a Lewis, Raychel M $u Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Ingelsson, Erik $u Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
- 700 1_
- $a Jakobsdottir, Johanna $u Icelandic Heart Association, Kópavogur, Iceland. The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Jonsdottir, Ingileif $u deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
- 700 1_
- $a Jonsson, Helgi $u Landspitalinn University Hospital, Reykjavík, Iceland. University of Iceland, Reykjavík, Iceland.
- 700 1_
- $a Joshi, Peter K $u Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Josyula, Navya Shilpa $u Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
- 700 1_
- $a Jung, Bettina $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
- 700 1_
- $a Kähönen, Mika $u Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Kamatani, Yoichiro $u Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan. Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- 700 1_
- $a Kanai, Masahiro $u Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
- 700 1_
- $a Kerr, Shona M $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Kiess, Wieland $u LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Kleber, Marcus E $u Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Koenig, Wolfgang $u Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
- 700 1_
- $a Kooner, Jaspal S $u Department of Cardiology, Ealing Hospital, London, UK. Imperial College Healthcare NHS Trust, Imperial College London, London, UK. MRC-PHE Centre for Environment and Health, 323 School of Public Health, Imperial College London, London, UK. National Heart and Lung Institute, Imperial College London, London, UK.
- 700 1_
- $a Körner, Antje $u LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Kovacs, Peter $u Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Krämer, Bernhard K $u Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Kronenberg, Florian $u Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
- 700 1_
- $a Kubo, Michiaki $u RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.
- 700 1_
- $a Kühnel, Brigitte $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
- 700 1_
- $a La Bianca, Martina $u Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
- 700 1_
- $a Lange, Leslie A $u Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
- 700 1_
- $a Lehne, Benjamin $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
- 700 1_
- $a Lehtimäki, Terho $u Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Liu, Jun $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Nuffield Department of Population Health, University of Oxford, Oxford, UK.
- 700 1_
- $a Loeffler, Markus $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Loos, Ruth J F $u The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 700 1_
- $a Lyytikäinen, Leo-Pekka $u Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Magi, Reedik $u Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Mahajan, Anubha $u Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
- 700 1_
- $a Martin, Nicholas G $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a März, Winfried $u Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
- 700 1_
- $a Mascalzoni, Deborah $u Eurac Research, Institute for Biomedicine, Bolzano, Italy.
- 700 1_
- $a Matsuda, Koichi $u Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
- 700 1_
- $a Meisinger, Christa $u Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.
- 700 1_
- $a Meitinger, Thomas $u German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. Institute of Human Genetics, Technische Universität München, Munich, Germany.
- 700 1_
- $a Metspalu, Andres $u Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Milaneschi, Yuri $u Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
- 700 1_
- $a O'Donnell, Christopher J $u VA Boston Healthcare System, Boston, MA, USA. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
- 700 1_
- $a Wilson, Otis D $u Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.
- 700 1_
- $a Gaziano, J Michael $u Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
- 700 1_
- $a Mishra, Pashupati P $u Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Mohlke, Karen L $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- 700 1_
- $a Mononen, Nina $u Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Montgomery, Grant W $u University of Queensland, St Lucia, Queensland, Australia.
- 700 1_
- $a Mook-Kanamori, Dennis O $u Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Müller-Nurasyid, Martina $u German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany. Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Nadkarni, Girish N $u The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 700 1_
- $a Nalls, Mike A $u Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Data Tecnica International, Glen Echo, MD, USA.
- 700 1_
- $a Nauck, Matthias $u DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Nikus, Kjell $u Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
- 700 1_
- $a Ning, Boting $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
- 700 1_
- $a Nolte, Ilja M $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 700 1_
- $a Noordam, Raymond $u Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a O'Connell, Jeffrey R $u University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Olafsson, Isleifur $u Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
- 700 1_
- $a Padmanabhan, Sandosh $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
- 700 1_
- $a Penninx, Brenda W J H $u Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
- 700 1_
- $a Perls, Thomas $u Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
- 700 1_
- $a Peters, Annette $u Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. German Center for Diabetes Research, Neuherberg, Germany. German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
- 700 1_
- $a Pirastu, Mario $u Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
- 700 1_
- $a Pirastu, Nicola $u Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Pistis, Giorgio $u Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
- 700 1_
- $a Polasek, Ozren $u Faculty of Medicine, University of Split, Split, Croatia. Gen-info Ltd, Zagreb, Croatia.
- 700 1_
- $a Ponte, Belen $u Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
- 700 1_
- $a Porteous, David J $u Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Poulain, Tanja $u LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Preuss, Michael H $u The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 700 1_
- $a Rabelink, Ton J $u Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands. Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Raffield, Laura M $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- 700 1_
- $a Raitakari, Olli T $u Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
- 700 1_
- $a Rettig, Rainer $u Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
- 700 1_
- $a Rheinberger, Myriam $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
- 700 1_
- $a Rice, Kenneth M $u Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 700 1_
- $a Rizzi, Federica $u Department of Health Sciences, University of Milan, Milano, Italy. ePhood Scientific Unit, ePhood SRL, Milano, Italy.
- 700 1_
- $a Robino, Antonietta $u Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
- 700 1_
- $a Rudan, Igor $u Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Krajcoviechova, Alena $u Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic. Thomayer Hospital, Prague, Czech Republic.
- 700 1_
- $a Cifkova, Renata $u Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic. Department of Medicine II, First Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Rueedi, Rico $u Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland.
- 700 1_
- $a Ruggiero, Daniela $u Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy. IRCCS Neuromed, Pozzilli, Italy.
- 700 1_
- $a Ryan, Kathleen A $u Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Saba, Yasaman $u Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
- 700 1_
- $a Salvi, Erika $u Department of Health Sciences, University of Milan, Milano, Italy. Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
- 700 1_
- $a Schmidt, Helena $u Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.
- 700 1_
- $a Schmidt, Reinhold $u Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
- 700 1_
- $a Shaffer, Christian M $u Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 700 1_
- $a Smith, Albert V $u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Smith, Blair H $u Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
- 700 1_
- $a Spracklen, Cassandra N $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
- 700 1_
- $a Strauch, Konstantin $u Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
- 700 1_
- $a Stumvoll, Michael $u Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Sulem, Patrick $u deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
- 700 1_
- $a Tajuddin, Salman M $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
- 700 1_
- $a Teren, Andrej $u LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. Heart Centre Leipzig, Leipzig, Germany.
- 700 1_
- $a Thiery, Joachim $u LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Thio, Chris H L $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 700 1_
- $a Thorsteinsdottir, Unnur $u deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
- 700 1_
- $a Toniolo, Daniela $u San Raffaele Research Institute, Milano, Italy.
- 700 1_
- $a Tönjes, Anke $u Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Tremblay, Johanne $u Montreal University Hospital Research Centre, Centre Hospitalier de lUniversité de Montréal, Montreal, Quebec, Canada. Centre de Recherche du CHUM, Montreal, Quebec, Canada.
- 700 1_
- $a Uitterlinden, André G $u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
- 700 1_
- $a Vaccargiu, Simona $u Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
- 700 1_
- $a van der Harst, Pim $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Durrer Centre for Cardiovascular Research, the Netherlands Heart Institute, Utrecht, the Netherlands.
- 700 1_
- $a van Duijn, Cornelia M $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Nuffield Department of Population Health, University of Oxford, Oxford, UK. Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
- 700 1_
- $a Verweij, Niek $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Genomics plc, Oxford, UK.
- 700 1_
- $a Völker, Uwe $u DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
- 700 1_
- $a Vollenweider, Peter $u Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
- 700 1_
- $a Waeber, Gerard $u Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
- 700 1_
- $a Waldenberger, Melanie $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
- 700 1_
- $a Whitfield, John B $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Wild, Sarah H $u Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Wilson, James F $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Yang, Qiong $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
- 700 1_
- $a Zhang, Weihua $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. Department of Cardiology, Ealing Hospital, London, UK.
- 700 1_
- $a Zonderman, Alan B $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
- 700 1_
- $a Bochud, Murielle $u Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
- 700 1_
- $a Wilson, James G $u Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA.
- 700 1_
- $a Pendergrass, Sarah A $u Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
- 700 1_
- $a Ho, Kevin $u Kidney Health Research Institute, Geisinger, Danville, PA, USA. Department of Nephrology, Geisinger, Danville, PA, USA.
- 700 1_
- $a Parsa, Afshin $u Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Pramstaller, Peter P $u Eurac Research, Institute for Biomedicine, Bolzano, Italy.
- 700 1_
- $a Psaty, Bruce M $u Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
- 700 1_
- $a Böger, Carsten A $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Traunstein, Germany.
- 700 1_
- $a Snieder, Harold $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
- 700 1_
- $a Butterworth, Adam S $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Okada, Yukinori $u Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Osaka, Japan. Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
- 700 1_
- $a Edwards, Todd L $u Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
- 700 1_
- $a Stefansson, Kari $u deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
- 700 1_
- $a Susztak, Katalin $u Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Scholz, Markus $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Heid, Iris M $u Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
- 700 1_
- $a Hung, Adriana M $u Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
- 700 1_
- $a Teumer, Alexander $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
- 700 1_
- $a Pattaro, Cristian $u Eurac Research, Institute for Biomedicine, Bolzano, Italy.
- 700 1_
- $a Woodward, Owen M $u Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Vitart, Veronique $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
- 700 1_
- $a Köttgen, Anna $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de. Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.
- 710 2_
- $a German Chronic Kidney Disease Study
- 710 2_
- $a Lifelines Cohort Study
- 710 2_
- $a V. A. Million Veteran Program
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- $a MC_QA137853 $p Medical Research Council $2 United Kingdom
- GRA __
- $a MC_PC_17228 $p Medical Research Council $2 United Kingdom
- GRA __
- $a P30 DK116074 $p NIDDK NIH HHS $2 United States
- LZP __
- $a Pubmed-20200511
