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Serum levels of TIMP-1 and MMP-7 as potential biomarkers in patients with metastatic colorectal cancer

M. Vočka, D. Langer, V. Fryba, J. Petrtyl, T. Hanus, M. Kalousova, T. Zima, L. Petruzelka,

. 2019 ; 34 (3) : 292-301. [pub] 20190904

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20005836

OBJECTIVE: Tissue inhibitor of metalloproteinases 1 (TIMP-1) and matrix metalloproteinase 7 (MMP-7) were reported to have potent growth promoting activity. Lack of balance between MMPs and TIMPs is an important factor in the development of gastrointestinal malignancies. METHODS: We collected serum samples from 97 patients with metastatic colorectal cancer and 79 samples from healthy controls. Serum levels of TIMP-1 and MMP-7 were measured immunochemically and compared with standard tumor markers carcinoembryonic antigen and CA19-9. RESULTS: Serum levels of TIMP-1 and MMP-7 were significantly higher in patients with colorectal cancer compared to healthy controls (both, P < 0.001). TIMP-1 and MMP-7 correlate with the presence of colon involvement (P = 0.001; P = 0.012) and the presence of liver metastases (P = 0.002; P = 0.037), and negatively correlate with pulmonary metastases (P = 0.014; P = 0.005). MMP-7 had similar sensitivity and the same specificity as carcinoembryonic antigen. TIMP-1 and MMP-7 had better sensitivity than CA19-9. TIMP-1 and MMP-7 level correlate with worse outcome (P = 0.002). CONCLUSION: The results indicate that TIMP-1 and MMP-7 are effective biomarkers in patients with metastatic colorectal cancer with good sensitivity. TIMP-1 and MMP-7 levels strongly correlate with the extent of liver disease and have prognostic value.

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$a Langer, Daniel $u Surgery Department, Second Faculty of Medicine, Charles University, and Military University Hospital in Prague, Prague, Czech Republic.
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$a Fryba, Vladimir $u First Department of Surgery - Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Czech Republic.
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$a Petrtyl, Jaromir $u Fourth Department of Internal Medicine - Department of Gastroenterology and Hepatology, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Czech Republic.
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$a Zima, Tomas $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University, and General University Hospital in Prague, Czech Republic.
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