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Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
AS. Guerreiro Stucklin, S. Ryall, K. Fukuoka, M. Zapotocky, A. Lassaletta, C. Li, T. Bridge, B. Kim, A. Arnoldo, PE. Kowalski, Y. Zhong, M. Johnson, C. Li, AK. Ramani, R. Siddaway, LF. Nobre, P. de Antonellis, C. Dunham, S. Cheng, DR. Boué, JL....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
702296
Canadian Cancer Society Research Institute (Société Canadienne du Cancer) - International
159805
Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) - International
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- analýza přežití MeSH
- anaplastická lymfomová kináza genetika metabolismus MeSH
- epigenomika metody MeSH
- gliom klasifikace genetika metabolismus MeSH
- kojenec MeSH
- lidé MeSH
- metylace DNA * MeSH
- nádory mozku klasifikace genetika metabolismus MeSH
- novorozenec MeSH
- protoonkogenní proteiny c-met genetika metabolismus MeSH
- protoonkogenní proteiny genetika metabolismus MeSH
- receptor trkA genetika metabolismus MeSH
- regulace genové exprese u nádorů * MeSH
- sekvenování exomu metody MeSH
- tyrosinkinasové receptory genetika metabolismus MeSH
- tyrosinkinasy genetika metabolismus MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Infant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinases ALK, ROS1, NTRK and MET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harbor RAS/MAPK pathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.
2nd Faculty of Medicine Charles University and University Hospital Motol Prague Czech Republic
Centre for Computational Medicine The Hospital for Sick Children Toronto ON Canada
Children's Cancer Center National Center for Child Health and Development Tokyo Japan
Children's Cancer Centre Royal Children's Hospital Melbourne Australia
Department of Hematology and Oncology The Hospital for Sick Children Toronto ON Canada
Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB Canada
Department of Medicine McGill University Montreal QC Canada
Department of Neurosurgery Kyorin University Faculty of Medicine Tokyo Japan
Department of Pathology and Laboratory Medicine University of Ottawa Ottawa ON Canada
Department of Pathology Hospital Universitario Niño Jesús Madrid Spain
Department of Pathology University Hospital de São João Porto Portugal
Department of Pediatric Hematology and Oncology Hospital Universitario Niño Jesús Madrid Spain
Department of Pediatric Laboratory Medicine The Hospital for Sick Children Toronto ON Canada
Department of Pediatric Neurosurgery Osaka City General Hospital Osaka Japan
Department of Pediatric Oncology Hospital Cruces Bilbao Spain
Department of Pediatric Oncology Hospital Infantil Virgen del Rocio Sevilla Spain
Department of Pediatric Oncology Hospital Sant Joan de Déu Barcelona Spain
Department of Pediatrics University of Alberta Edmonton AB Canada
Division of Brain Tumor Translational Research National Cancer Center Research Institute Tokyo Japan
Division of Hematology Oncology Children's Hospital of Eastern Ontario Ottawa ON Canada
Division of Hematology Oncology IWK Health Centre Halifax NS Canada
Division of Neurosurgery IWK Health Centre Halifax NS Canada
Division of Pediatric Hematology Oncology Mayo Clinic Rochester MN USA
Division of Pediatric Hematoncology University Hospital de São João Porto Portugal
Institute of Neuropathology University Hospital Zurich Zurich Switzerland
The Department of Pediatric Hematology Oncology Hadassah Medical Center Jerusalem Israel
Citace poskytuje Crossref.org
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