• Je něco špatně v tomto záznamu ?

Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors

N. Maráková, ZA. Boeva, P. Humpolíček, T. Lindfors, J. Pacherník, V. Kašpárková, KA. Radaszkiewicz, Z. Capáková, A. Minařík, M. Lehocký,

. 2019 ; 105 (-) : 110029. [pub] 20190729

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005873

The cytocompatibility of cardiomyocytes derived from embryonic stem cells and neural progenitors, which were seeded on the surface of composite films made of graphene oxide (GO) and polypyrrole (PPy-GO) or poly(3,4-ethylenedioxythiophene) (PEDOT-GO) are reported. The GO incorporated in the composite matrix contributes to the patterning of the composite surface, while the electrically conducting PPy and PEDOT serve as ion-to-electron transducers facilitating electrical stimulation/sensing. The films were fabricated by a simple one-step electropolymerization procedure on electrically conducting indium tin oxide (ITO) and graphene paper (GP) substrates. Factors affecting the cell behaviour, i.e. the surface topography, wettability, and electrical surface conductivity, were studied. The PPy-GO and PEDOT-GO prepared on ITO exhibited high surface conductivity, especially in the case of the ITO/PPy-GO composite. We found that for cardiomyocytes, the PPy-GO and PEDOT-GO composites counteracted the negative effect of the GP substrate that inhibited their growth. Both the PPy-GO and PEDOT-GO composites prepared on ITO and GP significantly decreased the cytocompatibility of neural progenitors. The presented results enhance the knowledge about the biological properties of electroactive materials, which are critical for tissue engineering, especially in context stimuli-responsive scaffolds.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20005873
003      
CZ-PrNML
005      
20240717093536.0
007      
ta
008      
200511e20190729ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.msec.2019.110029 $2 doi
035    __
$a (PubMed)31546373
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Maráková, Nela $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic.
245    10
$a Electrochemically prepared composites of graphene oxide and conducting polymers: Cytocompatibility of cardiomyocytes and neural progenitors / $c N. Maráková, ZA. Boeva, P. Humpolíček, T. Lindfors, J. Pacherník, V. Kašpárková, KA. Radaszkiewicz, Z. Capáková, A. Minařík, M. Lehocký,
520    9_
$a The cytocompatibility of cardiomyocytes derived from embryonic stem cells and neural progenitors, which were seeded on the surface of composite films made of graphene oxide (GO) and polypyrrole (PPy-GO) or poly(3,4-ethylenedioxythiophene) (PEDOT-GO) are reported. The GO incorporated in the composite matrix contributes to the patterning of the composite surface, while the electrically conducting PPy and PEDOT serve as ion-to-electron transducers facilitating electrical stimulation/sensing. The films were fabricated by a simple one-step electropolymerization procedure on electrically conducting indium tin oxide (ITO) and graphene paper (GP) substrates. Factors affecting the cell behaviour, i.e. the surface topography, wettability, and electrical surface conductivity, were studied. The PPy-GO and PEDOT-GO prepared on ITO exhibited high surface conductivity, especially in the case of the ITO/PPy-GO composite. We found that for cardiomyocytes, the PPy-GO and PEDOT-GO composites counteracted the negative effect of the GP substrate that inhibited their growth. Both the PPy-GO and PEDOT-GO composites prepared on ITO and GP significantly decreased the cytocompatibility of neural progenitors. The presented results enhance the knowledge about the biological properties of electroactive materials, which are critical for tissue engineering, especially in context stimuli-responsive scaffolds.
650    _2
$a zvířata $7 D000818
650    _2
$a bicyklické sloučeniny heterocyklické $x chemie $7 D019086
650    12
$a elektrická vodivost $7 D004553
650    12
$a elektrochemie $7 D004563
650    _2
$a grafit $x farmakologie $7 D006108
650    _2
$a myši $7 D051379
650    _2
$a kardiomyocyty $x cytologie $x účinky léků $7 D032383
650    _2
$a nervové kmenové buňky $x cytologie $x účinky léků $7 D058953
650    _2
$a neurogeneze $x účinky léků $7 D055495
650    _2
$a polymery $x chemie $x farmakologie $7 D011108
650    _2
$a pyrroly $x chemie $7 D011758
650    _2
$a voda $x chemie $7 D014867
655    _2
$a časopisecké články $7 D016428
700    1_
$a Boeva, Zhanna A $u Åbo Akademi University, Faculty of Science and Engineering, Johan Gadolin Process Chemistry Centre (PCC), Laboratory of Analytical Chemistry, Biskopsgatan 8, 20500 Åbo, Finland.
700    1_
$a Humpolíček, Petr $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic. Electronic address: humpolicek@utb.cz.
700    1_
$a Lindfors, Tom $u Åbo Akademi University, Faculty of Science and Engineering, Johan Gadolin Process Chemistry Centre (PCC), Laboratory of Analytical Chemistry, Biskopsgatan 8, 20500 Åbo, Finland. Electronic address: tom.lindfors@abo.fi.
700    1_
$a Pacherník, Jiří $u Institute of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
700    1_
$a Kašpárková, Věra $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic.
700    1_
$a Radaszkiewicz, Katarzyna $u Institute of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic. $7 xx0320047
700    1_
$a Capáková, Zdenka $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic.
700    1_
$a Minařík, Antonín $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic.
700    1_
$a Lehocký, Marián $u Centre of Polymer Systems, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic; Faculty of Technology, Tomas Bata University in Zlin, 760 01 Zlin, Czech Republic.
773    0_
$w MED00184559 $t Materials science & engineering. C, Materials for biological applications $x 1873-0191 $g Roč. 105 (20190729), s. 110029
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31546373 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20240717093532 $b ABA008
999    __
$a ok $b bmc $g 1524731 $s 1095929
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 105 $c - $d 110029 $e 20190729 $i 1873-0191 $m Materials science & engineering. C, Materials for biological applications $n Mater Sci Eng C Mater Biol Appl $x MED00184559
LZP    __
$a Pubmed-20200511

Najít záznam

Citační ukazatele

Možnosti archivace