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ECMM CandiReg-A ready to use platform for outbreaks and epidemiological studies

P. Koehler, MC. Arendrup, S. Arikan-Akdagli, M. Bassetti, S. Bretagne, L. Klingspor, K. Lagrou, JF. Meis, R. Rautemaa-Richardson, S. Schelenz, A. Hamprecht, FC. Koehler, O. Kurzai, J. Salmanton-García, JJ. Vehreschild, A. Alanio, A....

. 2019 ; 62 (10) : 920-927. [pub] 20190801

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc20006191

Grantová podpora
MR/N006364/1 Medical Research Council - United Kingdom
University of Cologne
European Confederation of Medical Mycology
Scynexis

BACKGROUND: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. OBJECTIVES: Triggered by the emergence of C auris and by increasing antifungal resistance rates the European Confederation of Medical Mycology developed an international Candida Registry (FungiScope™ CandiReg) to allow contemporary multinational surveillance. METHODS: CandiReg serves as platform for international cooperation to enhance research regarding invasive Candida infections. CandiReg uses the General Data Protection Regulation compliant data platform ClinicalSurveys.net that holds the electronic case report forms (eCRF). Data entry is supported via an interactive macro created by the software that can be accessed via any Internet browser. RESULTS: CandiReg provides an eCRF for invasive Candida infections that can be used for a variety of studies from cohort studies on attributable mortality to evaluations of guideline adherence, offering to the investigators of the 28 ECMM member countries the opportunity to document their cases of invasive Candida infection. CandiReg allows the monitoring of epidemiology of invasive Candida infections, including monitoring of multinational outbreaks. Here, we describe the structure and management of the CandiReg platform. CONCLUSION: CandiReg supports the collection of clinical information and isolates to improve the knowledge on epidemiology and eventually to improve management of invasive Candida infections. CandiReg promotes international collaboration, improving the availability and quality of evidence on invasive Candida infection and contributes to improved patient management.

Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases University of Cologne Cologne Germany Faculty of Medicine Department 2 of Internal Medicine Center for Molecular Medicine Cologne University of Cologne Cologne Germany

Department of Biomedical Sciences for Health Università degli Studi di Milano Milan Italy

Department of Clinical Microbiology and Immunology Sackler School of Medicine Tel Aviv University Tel Aviv Israel

Department of Clinical Microbiology Karolinska University Hospital Stockholm Sweden Division of Clinical Microbiology Department of Laboratory Medicine Karolinska Institutet Stockholm Sweden

Department of Clinical Microbiology Royal College of Surgeons Ireland Dublin Ireland Microbiology Department Our Lady of Lourdes Hospital Drogheda Ireland Department of Microbiology Beaumont Hospital Dublin 9 Ireland

Department of Clinical Mycology Allergy and Immunology North Western State Medical University Saint Petersburg Russia

Department of Infectious Diseases and Mycology Reference Centre Manchester Manchester University NHS Foundation Trust Manchester UK Division of Infection Immunity and Respiratory Medicine Faculty of Biology Medicine and Health The University of Manchester Manchester UK

Department of Infectious Diseases Nacional Institute of Health Dr Ricardo Jorge Reference Unit for Parasitic and Fungal Infections Lisbon Portugal

Department of Laboratory Medicine Clinical Microbiology Karolinska Institutet Karolinska University Hospital Stockholm Sweden

Department of Medical Microbiology and Infectious Diseases Excellence Center for Medical Mycology Center of Expertise in Mycology Radboudumc CWZ Canisius Wilhelmina Hospital Nijmegen The Netherlands

Department of Medical Microbiology Excellence Center for Medical Mycology Center of Expertise in Mycology Radboudumc CWZ Nijmegen The Netherlands

Department of Medical Microbiology Hacettepe University School of Medicine Ankara Turkey

Department of Medicine Infectious Diseases Clinic University of Udine and Azienda Sanitaria Universitaria Integrata di Udine Udine Italy

Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of Zagreb Zagreb Croatia

Department of Microbiology Faculty of Medicine and Dentistry Palacky University Olomouc Olomouc Czechia University Hospital Olomouc Olomouc Czechia

Department of Microbiology Royal Brompton Hospital London UK

Division of Hygiene and Medical Microbiology Excellence Center for Medical Mycology Medical University of Innsbruck Innsbruck Austria

Faculty of Medicine Department 1 of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany

Faculty of Medicine Department 1 of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf University of Cologne Cologne Germany Center for Internal Medicine Hematology and Oncology University Hospital of Frankfurt Goethe University Frankfurt Germany German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany

Infectious Diseases Unit 3rd Department of Pediatrics Faculty of Medicine Hippokration General Hospital Aristotle University School of Health Sciences Thessaloniki Greece

Institut de Recherche en Santé Environnement et travail Inserm CHU de Rennes EHESP UMR_S 1085 Université de Rennes Rennes France

Institute for Medical Microbiology Immunology and Hygiene University Hospital of Cologne Cologne Germany

Laboratory of Antimicrobial Chemotherapy Ion Ionescu de la Brad University Iași Romania

Laboratory of Clinical Bacteriology and Mycology Department of Microbiology Immunology and Transplantation Excellence Center for Medical Mycology University Hospitals Leuven Leuven Belgium

MTA SZTE Fungal Pathogenicity Mechanisms Research Group Department of Microbiology University of Szeged Szeged Hungary

National Centre for Micobiology Instituto de Salud Carlos 3 Madrid Spain

National Reference Center for Invasive Fungal Infections Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute Jena Germany Institute for Hygiene and Microbiology Julius Maximilians University of Wuerzburg Wuerzburg Germany

National Reference Medical Mycology Laboratory Faculty of Medicine Institute of Microbiology and Immunology University of Belgrade Belgrade Serbia

Parasitology Mycology Laboratory Lariboisière Saint Louis Fernand Widal Hospitals Assistance Publique Hôpitaux de Paris Molecular Mycology Unit CNRS UMR2000 Institut Pasteur Université de Paris Paris France

Public Health England Mycology Reference Laboratory National Infection Services PHE South West Laboratory Science Quarter Southmead Hospital Southmead Bristol UK

School of Biosciences University of Exeter Exeter UK

Section of Infectious Diseases and Tropical Medicine Medical University of Graz Graz Austria Division of Infectious Diseases Department of Medicine UCSD San Diego California

Unit of Mycology Statens Serum Institute Copenhagen Denmark Department of Clinical Microbiology Rigshospitalet Copenhagen Denmark Department of Clinical Medicine Copenhagen University Copenhagen Denmark

Citace poskytuje Crossref.org

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$a BACKGROUND: Recent outbreaks of Candida auris further exemplify that invasive Candida infections are a substantial threat to patients and healthcare systems. Even short treatment delays are associated with higher mortality rates. Epidemiological shifts towards more resistant Candida spp. require careful surveillance. OBJECTIVES: Triggered by the emergence of C auris and by increasing antifungal resistance rates the European Confederation of Medical Mycology developed an international Candida Registry (FungiScope™ CandiReg) to allow contemporary multinational surveillance. METHODS: CandiReg serves as platform for international cooperation to enhance research regarding invasive Candida infections. CandiReg uses the General Data Protection Regulation compliant data platform ClinicalSurveys.net that holds the electronic case report forms (eCRF). Data entry is supported via an interactive macro created by the software that can be accessed via any Internet browser. RESULTS: CandiReg provides an eCRF for invasive Candida infections that can be used for a variety of studies from cohort studies on attributable mortality to evaluations of guideline adherence, offering to the investigators of the 28 ECMM member countries the opportunity to document their cases of invasive Candida infection. CandiReg allows the monitoring of epidemiology of invasive Candida infections, including monitoring of multinational outbreaks. Here, we describe the structure and management of the CandiReg platform. CONCLUSION: CandiReg supports the collection of clinical information and isolates to improve the knowledge on epidemiology and eventually to improve management of invasive Candida infections. CandiReg promotes international collaboration, improving the availability and quality of evidence on invasive Candida infection and contributes to improved patient management.
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$a Rautemaa-Richardson, Riina $u Department of Infectious Diseases and Mycology Reference Centre Manchester, Manchester University NHS Foundation Trust, Manchester, UK. Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
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$a Schelenz, Silke $u Department of Microbiology, Royal Brompton Hospital, London, UK.
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$a Kurzai, Oliver $u National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knoell Institute, Jena, Germany. Institute for Hygiene and Microbiology, Julius Maximilians University of Wuerzburg, Wuerzburg, Germany.
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$a Salmanton-García, Jon $u Faculty of Medicine, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
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$a Vehreschild, Jörg-Janne $u Faculty of Medicine, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf (CIO ABCD), Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany. Center for Internal Medicine, Hematology and Oncology, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany. German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany.
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$a Alanio, Alexandre $u Parasitology-Mycology Laboratory, Lariboisière Saint-Louis Fernand Widal Hospitals, Assistance Publique-Hôpitaux de Paris (APHP), Molecular Mycology Unit, CNRS, UMR2000, Institut Pasteur, Université de Paris, Paris, France.
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$a Alastruey-Izquierdo, Ana $u National Centre for Micobiology, Instituto de Salud Carlos III, Madrid, Spain.
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$a Arsic Arsenijevic, Valentina $u National Reference Medical Mycology Laboratory, Faculty of Medicine, Institute of Microbiology and Immunology, University of Belgrade, Belgrade, Serbia.
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$a Gangneux, Jean-Pierre $u Institut de Recherche en Santé, Environnement et travail, Inserm, CHU de Rennes, EHESP, UMR_S 1085, Université de Rennes, Rennes, France.
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$a Gow, Neil A R $u School of Biosciences, University of Exeter, Exeter, UK.
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$a Hadina, Suzana $u Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
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$a Hamal, Petr $u Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czechia. University Hospital Olomouc, Olomouc, Czechia.
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$a Johnson, Elizabeth $u Public Health England Mycology Reference Laboratory, National Infection Services, PHE South West Laboratory, Science Quarter, Southmead Hospital, Southmead, Bristol, UK.
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$a Mares, Mihai $u Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University, Iași, Romania.
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$a Özenci, Volkan $u Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
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$a Tortorano, Anna Maria $u Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
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$a Verweij, Paul E $u Department of Medical Microbiology, Excellence Center for Medical Mycology (ECMM), Center of Expertise in Mycology Radboudumc/CWZ, Nijmegen, The Netherlands.
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