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Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import?

M. Hlavackova, E. Kardami, R. Fandrich, GN. Pierce,

. 2019 ; 126 (-) : 140-142. [pub] 20181128

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20006706

The functional significance of having two nuclei in a cell is unknown. Having two stores of genetic material may be advantageous for cell growth. Nuclear protein import is at a critical juncture in the cell to modify cell growth. This study addressed the potential for differential nuclear protein import in two nuclei of the same cell. Isolated adult rat cardiomyocytes were microinjected with an exogenous fluorescent protein conjugated with nuclear localization amino acid sequences to facilitate nuclear import and its detection. Our results demonstrate the rate of nuclear protein import was not significantly different between the two nuclei in the same cell. These data demonstrate that the two nuclei are functionally similar in a binucleated cardiomyocyte, at least as far as nucleocytoplasmic transport is concerned.

Citace poskytuje Crossref.org

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$a Hlavackova, Marketa $u Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic; Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St Boniface Hospital, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
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$a Do different nuclei in a binucleated cardiomyocyte have different rates of nuclear protein import? / $c M. Hlavackova, E. Kardami, R. Fandrich, GN. Pierce,
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$a Kardami, Elissavet $u Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St Boniface Hospital, Winnipeg, Canada; Anatomy and Cell Biology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
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$a Fandrich, Robert $u Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St Boniface Hospital, Winnipeg, Canada; Anatomy and Cell Biology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
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$a Pierce, Grant N $u Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St Boniface Hospital, Winnipeg, Canada; Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada. Electronic address: gpierce@sbrc.ca.
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