Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients

A. Jurczyszyn, JJ. Castillo, I. Avivi, J. Czepiel, J. Davila, R. Vij, MA. Fiala, A. Gozzetti, N. Grząśko, V. Milunovic, I. Hus, K. Mądry, A. Waszczuk-Gajda, L. Usnarska-Zubkiewicz, J. Dębski, E. Atilla, M. Beksac, G. Mele, W. Sawicki, D....

. 2019 ; 60 (1) : 118-123. [pub] 20180702

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc20006809

This multicenter retrospective study included 101 patients (median age 62 years) with secondary plasma cell leukemia (sPCL). The median time from initial multiple myeloma diagnosis to sPCL was 31 months. Fifty-five out of 72 patients (75%) who received any therapy were treated with immunomodulators (IMiDs) and/or proteasome inhibitors (PIs), and 14/72 (19%) underwent salvage autologous stem cell transplantation (ASCT). The overall response rate in patients who received ASCT or PI (either alone or in combination) was higher than in those who did not (93% vs. 36% and 60% vs. 30%, respectively). The median overall survival (OS) in patients who received therapy was 4.2 months (95% CI: 1.3; 8.0) with a 1-year OS of 19%. Platelet count ≤100 × 109/L at sPCL diagnosis was the only independent predictor of a poorer OS in treated patients (HR = 3.98, p = .0001). These findings suggest that patients with sPCL may benefit from salvage ASCT- and PI-based regimens.

b Dana Farber Cancer Institute Harvard Medical School Boston MA USA

b John Theurer Cancer Center Myeloma Division Hackensack University Medical Center Hackensack NJ USA

c Tel Aviv Medical Center Tel Aviv Israel

Department of Infectious and Tropical Diseases Jagiellonian University Medical College Cracow Poland

e Hospital Universitario de Salamanca Salamanca Spain

f Washington University School of Medicine Saint Louis MO USA

g Le Scotte Hospital Siena Italy

h Department of Hematology St John's Cancer Center Lublin Poland i Department of Experimental Hematology Medical University of Lublin Lublin Poland

Hematology Department and Bone Marrow Transplantation Unit Ankara University Medical School Ankara Turkey

Hematology Department Jagiellonian University Medical College Cracow Poland

j Division of Hematology Clinical Hospital Merkur Zagreb Croatia

k Department of Haematology and Bone Marrow Transplantation Medical University of Lublin Lublin Poland

l Department of Hematology Oncology and Internal Medicine Warsaw Medical University Warsaw Poland

m Department of Hematology Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University Wroclaw Poland

o Ospedale A Perrino Haematology Brindisi Italy

p Department of Internal Medicine and Hematology Military Institute of Medicine Warsaw Poland

q Weill Cornell Medical College New York NY USA

r Department of Hematology Nicolaus Copernicus Hospital Torun Poland

Rutgers New Jersey Medical School Newark NJ USA

s Department of Medicine Section of Hematology Vejle Denmark

t Faculty of Medicine University Hospital Ostrava University of Ostrava Ostrava Czech Republic

u Department of Hematology UZ Leuven Leuven Belgium

v Teaching Hospital No 1 Rzeszów Poland

w Seccion Hematologia Adultos Hospital Italiano de Buenos Aires Buenos Aires Argentina

x Norwegian University of Science and Technology St Olav's Hospital Trondheim Norway

y Hospital Universitario Professor Edgar Santos Salvador Brazil

z Division of Hematology and Oncology Dana Farber Cancer Institute at St Elizabeth's Medical Center Brighton MA USA

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20006809
003      
CZ-PrNML
005      
20200519143652.0
007      
ta
008      
200511s2019 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1080/10428194.2018.1473574 $2 doi
035    __
$a (PubMed)29965787
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Jurczyszyn, Artur $u a Hematology Department , Jagiellonian University Medical College , Cracow , Poland.
245    10
$a Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients / $c A. Jurczyszyn, JJ. Castillo, I. Avivi, J. Czepiel, J. Davila, R. Vij, MA. Fiala, A. Gozzetti, N. Grząśko, V. Milunovic, I. Hus, K. Mądry, A. Waszczuk-Gajda, L. Usnarska-Zubkiewicz, J. Dębski, E. Atilla, M. Beksac, G. Mele, W. Sawicki, D. Jayabalan, G. Charliński, A. Gyula Szabo, R. Hajek, M. Delforge, A. Kopacz, D. Fantl, A. Waage, E. Crusoe, V. Hungria, P. Richardson, J. Laubach, T. Guerrero-Garcia, J. Liu, DH. Vesole,
520    9_
$a This multicenter retrospective study included 101 patients (median age 62 years) with secondary plasma cell leukemia (sPCL). The median time from initial multiple myeloma diagnosis to sPCL was 31 months. Fifty-five out of 72 patients (75%) who received any therapy were treated with immunomodulators (IMiDs) and/or proteasome inhibitors (PIs), and 14/72 (19%) underwent salvage autologous stem cell transplantation (ASCT). The overall response rate in patients who received ASCT or PI (either alone or in combination) was higher than in those who did not (93% vs. 36% and 60% vs. 30%, respectively). The median overall survival (OS) in patients who received therapy was 4.2 months (95% CI: 1.3; 8.0) with a 1-year OS of 19%. Platelet count ≤100 × 109/L at sPCL diagnosis was the only independent predictor of a poorer OS in treated patients (HR = 3.98, p = .0001). These findings suggest that patients with sPCL may benefit from salvage ASCT- and PI-based regimens.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    _2
$a imunologické faktory $x terapeutické užití $7 D007155
650    _2
$a plazmocelulární leukemie $x etiologie $x mortalita $x terapie $7 D007952
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a mnohočetný myelom $x komplikace $x mortalita $x terapie $7 D009101
650    _2
$a inhibitory proteasomu $x terapeutické užití $7 D061988
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a záchranná terapie $x metody $7 D016879
650    12
$a transplantace kmenových buněk $7 D033581
650    _2
$a analýza přežití $7 D016019
650    _2
$a autologní transplantace $7 D014182
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
700    1_
$a Castillo, Jorge J $u b Dana-Farber Cancer Institute , Harvard Medical School , Boston , MA , USA.
700    1_
$a Avivi, Irit $u c Tel Aviv Medical Center , Tel Aviv , Israel.
700    1_
$a Czepiel, Jacek $u d Department of Infectious and Tropical Diseases , Jagiellonian University Medical College , Cracow , Poland.
700    1_
$a Davila, Julio $u e Hospital Universitario de Salamanca , Salamanca , Spain.
700    1_
$a Vij, Ravi $u f Washington University School of Medicine , Saint Louis , MO , USA.
700    1_
$a Fiala, Mark A $u f Washington University School of Medicine , Saint Louis , MO , USA.
700    1_
$a Gozzetti, Alessandro $u g Le Scotte Hospital , Siena , Italy.
700    1_
$a Grząśko, Norbert $u h Department of Hematology , St John's Cancer Center , Lublin , Poland. i Department of Experimental Hematology , Medical University of Lublin , Lublin, Poland.
700    1_
$a Milunovic, Vibor $u j Division of Hematology , Clinical Hospital Merkur , Zagreb , Croatia.
700    1_
$a Hus, Iwona $u k Department of Haematology and Bone Marrow Transplantation , Medical University of Lublin , Lublin , Poland.
700    1_
$a Mądry, Krzysztof $u l Department of Hematology, Oncology and Internal Medicine , Warsaw Medical University , Warsaw , Poland.
700    1_
$a Waszczuk-Gajda, Anna $u l Department of Hematology, Oncology and Internal Medicine , Warsaw Medical University , Warsaw , Poland.
700    1_
$a Usnarska-Zubkiewicz, Lidia $u m Department of Hematology , Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University , Wroclaw , Poland.
700    1_
$a Dębski, Jakub $u m Department of Hematology , Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University , Wroclaw , Poland.
700    1_
$a Atilla, Erden $u n Hematology Department and Bone Marrow Transplantation Unit , Ankara University Medical School , Ankara , Turkey.
700    1_
$a Beksac, Meral $u n Hematology Department and Bone Marrow Transplantation Unit , Ankara University Medical School , Ankara , Turkey.
700    1_
$a Mele, Giuseppe $u o Ospedale A. Perrino, Haematology , Brindisi , Italy.
700    1_
$a Sawicki, Waldemar $u p Department of Internal Medicine and Hematology , Military Institute of Medicine , Warsaw , Poland.
700    1_
$a Jayabalan, David $u q Weill Cornell Medical College , New York , NY , USA.
700    1_
$a Charliński, Grzegorz $u r Department of Hematology , Nicolaus Copernicus Hospital , Torun , Poland.
700    1_
$a Gyula Szabo, Agoston $u s Department of Medicine , Section of Hematology , Vejle , Denmark.
700    1_
$a Hajek, Roman $u t Faculty of Medicine, University Hospital Ostrava , University of Ostrava , Ostrava , Czech Republic.
700    1_
$a Delforge, Michel $u u Department of Hematology , UZ Leuven , Leuven, Belgium.
700    1_
$a Kopacz, Agnieszka $u v Teaching Hospital No. 1 , Rzeszów , Poland.
700    1_
$a Fantl, Dorotea $u w Seccion Hematologia Adultos , Hospital Italiano de Buenos Aires , Buenos Aires, Argentina.
700    1_
$a Waage, Anders $u x Norwegian University of Science and Technology, St. Olav's Hospital , Trondheim , Norway.
700    1_
$a Crusoe, Edvan $u y Hospital Universitario Professor Edgar Santos , Salvador , Brazil.
700    1_
$a Hungria, Vania $u y Hospital Universitario Professor Edgar Santos , Salvador , Brazil.
700    1_
$a Richardson, Paul $u b Dana-Farber Cancer Institute , Harvard Medical School , Boston , MA , USA.
700    1_
$a Laubach, Jacob $u b Dana-Farber Cancer Institute , Harvard Medical School , Boston , MA , USA.
700    1_
$a Guerrero-Garcia, Thomas $u z Division of Hematology and Oncology , Dana-Farber Cancer Institute at St. Elizabeth's Medical Center , Brighton , MA , USA.
700    1_
$a Liu, Jieqi $u aa Rutgers New Jersey Medical School , Newark , NJ , USA.
700    1_
$a Vesole, David H $u ab John Theurer Cancer Center, Myeloma Division , Hackensack University Medical Center , Hackensack , NJ , USA.
773    0_
$w MED00003140 $t Leukemia & lymphoma $x 1029-2403 $g Roč. 60, č. 1 (2019), s. 118-123
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29965787 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200519143648 $b ABA008
999    __
$a ok $b bmc $g 1525667 $s 1096865
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 60 $c 1 $d 118-123 $e 20180702 $i 1029-2403 $m Leukemia & lymphoma $n Leuk Lymphoma $x MED00003140
LZP    __
$a Pubmed-20200511

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace