Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Hypotension as a symptom of autonomic neuropathy in patients with advanced malignancies

F. Kohutek, J. Katrlik, B. Bystricky

. 2019 ; 163 (4) : 331-334. [pub] 20181211

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20010317

AIMS: Hypotension can be a symptom of paraneoplastic autonomic neuropathy (PAN). Onconeural antibodies (OA) provide strong evidence for the paraneoplastic origin of neurological syndromes. Our goal was to assess the frequency of PAN among patients with advanced malignancies and hypotension using OA. METHODS: Patients with advanced malignancies and hypotension were screened and enrolled as per protocol. Plasma levels of six classical OAs were assessed in these patients. We prospectively evaluated other symptoms of PAN in these patients. RESULTS: 31 patients out of 740 screened met the criteria of this cross-sectional study. OAs were present in 4 patients (12.9%). Anti-amphiphysin was found in 1 patient (3.23%), anti- CV2 (anti-CRPM5, anti- collapsin- response mediator protein) was present in 1 patient (3.23%), 1 patient (3.23%) was positive for anti-Hu and anti-Ma2 was present in 1 patient (3.23%). No patient was positive for 2 or more OAs. Normalization of blood pressure in concordance with partial remission occurred in 5 patients. The most used criteria for PAN were fulfilled in 9 patients. CONCLUSION: The frequency of PAN may be underestimated in a busy oncology clinic. Assessing OAs may aid in the differential diagnosis of hypotension of unknown origin.

References provided by Crossref.org

Bibliography, etc.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20010317
003      
CZ-PrNML
005      
20200720150808.0
007      
ta
008      
200707s2019 xr f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2018.073 $2 doi
035    __
$a (PubMed)30546151
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Kohútek, Filip $7 xx0250174 $u Department of Oncology, Faculty Hospital Trencin, Trencin, Slovak Republic
245    10
$a Hypotension as a symptom of autonomic neuropathy in patients with advanced malignancies / $c F. Kohutek, J. Katrlik, B. Bystricky
504    __
$a Literatura
520    9_
$a AIMS: Hypotension can be a symptom of paraneoplastic autonomic neuropathy (PAN). Onconeural antibodies (OA) provide strong evidence for the paraneoplastic origin of neurological syndromes. Our goal was to assess the frequency of PAN among patients with advanced malignancies and hypotension using OA. METHODS: Patients with advanced malignancies and hypotension were screened and enrolled as per protocol. Plasma levels of six classical OAs were assessed in these patients. We prospectively evaluated other symptoms of PAN in these patients. RESULTS: 31 patients out of 740 screened met the criteria of this cross-sectional study. OAs were present in 4 patients (12.9%). Anti-amphiphysin was found in 1 patient (3.23%), anti- CV2 (anti-CRPM5, anti- collapsin- response mediator protein) was present in 1 patient (3.23%), 1 patient (3.23%) was positive for anti-Hu and anti-Ma2 was present in 1 patient (3.23%). No patient was positive for 2 or more OAs. Normalization of blood pressure in concordance with partial remission occurred in 5 patients. The most used criteria for PAN were fulfilled in 9 patients. CONCLUSION: The frequency of PAN may be underestimated in a busy oncology clinic. Assessing OAs may aid in the differential diagnosis of hypotension of unknown origin.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a autoprotilátky $x krev $7 D001323
650    _2
$a autonomní nervový systém $x patofyziologie $7 D001341
650    _2
$a nádorové biomarkery $x krev $7 D014408
650    _2
$a průřezové studie $7 D003430
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a hypotenze $x etiologie $7 D007022
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a metastázy nádorů $x patofyziologie $7 D009362
650    _2
$a nádory $x komplikace $x patofyziologie $7 D009369
650    _2
$a nemoci nervového systému $x etiologie $7 D009422
655    _2
$a časopisecké články $7 D016428
700    1_
$a Katrlík, Jaroslav $7 xx0250172 $u Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovak Republic
700    1_
$a Bystrický, Branislav $7 xx0195736 $u Department of Oncology, Faculty Hospital Trencin, Trencin, Slovak Republic
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia $x 1213-8118 $g Roč. 163, č. 4 (2019), s. 331-334
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30546151 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y p $z 0
990    __
$a 20200707 $b ABA008
991    __
$a 20200717091117 $b ABA008
999    __
$a ok $b bmc $g 1545958 $s 1100409
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 163 $c 4 $d 331-334 $e 20181211 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20200707

Find record

Citation metrics

Archiving options