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Ultrashort ssDNA in retinoblastoma patients blood plasma detected by a novel high resolution HPLC technique: a preliminary report
KV. Ermakov, AA. Bukhvostov, AS. Vedenkin, SV. Stovbun, AS. Dvornikov, DA. Kuznetsov
Language English Country Czech Republic
Document type Journal Article
Digital library NLK
Source
NLK
Directory of Open Access Journals
from 1997
Free Medical Journals
from 1997
Open Access Digital Library
from 1997-01-01
Medline Complete (EBSCOhost)
from 2012-06-01
ROAD: Directory of Open Access Scholarly Resources
from 1997
- MeSH
- Adult MeSH
- DNA, Single-Stranded * MeSH
- Humans MeSH
- Biomarkers, Tumor genetics MeSH
- Retinal Neoplasms diagnosis genetics MeSH
- Child, Preschool MeSH
- Retinoblastoma diagnosis genetics MeSH
- Case-Control Studies MeSH
- Chromatography, High Pressure Liquid methods MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Publication type
- Journal Article MeSH
A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL-1), but not in plasma of healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve this task, a novel molecular size exclusion - anion exchange analytical technique was developed. Its applicability to diagnostics and oncogenesis research is quizzed here.
References provided by Crossref.org
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- $a A significant population of ultrashort (50-150n) single-stranded DNA fragments were found in exosome-free blood plasma of retinoblastoma patients (6.84 ng mL-1), but not in plasma of healthy donors. An original high resolution HPLC technique has been proposed to reveal and characterize this peculiarity. To solve this task, a novel molecular size exclusion - anion exchange analytical technique was developed. Its applicability to diagnostics and oncogenesis research is quizzed here.
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