Introduction: The objective of the study was to examine the relationship between the values of selected parameters of physical function, body composition, body mass index (BMI) and biochemical markers of metabolic health with the total testosterone (TT) levels in adult males. We aimed to analyse the correlation between these values and variations in the TT levels. Methods: A total of 17 subjects (age = 50.2 ± 8.1 years, TT = 11.4 ± 3.8 nmol/l) were included in the study. Subjects were tested on physical function (1RM on leg press, bench-press, handgrip, VO2max), body composition (DXA), biochemical parameters (morning fasting blood samples). Results: TT was inversely correlated with abdominal circumference (AC) (p < 0.01) and with overall body fat, measured in kg (p < 0.01). On a biochemical level, significant correlations were found between TT and insulin (p < 0.01), and TT and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.01). Physical function, muscle strength or lean mass were not significantly correlated with TT. Conclusion: The main finding of this study was that testosterone levels had a strong inverse correlation with abdominal circumference and total body fat mass. On metabolic level, strong inverse correlation was also found between TT with insulin and TT with HOMA-IR. However, we did not find statistically significant correlation between total testosterone levels and lean mass, muscle strength or physical function in middle aged males.

5th Department of Internal Medicine Faculty of Medicine Comenius University in Bratislava University Hospital Bratislava Slovak Republic

Deparment of Urology Faculty of Medicine Comenius University in Bratislava University Hospital Bratislava Slovak Republic

Department of Biological and Medical Sciences Faculty of Physical Education and Sport Comenius University in Bratislava Slovak Republic

Department of Metabolic Disease Research Institute of Experimental Endocrinology Biomedical Research Center Slovak Academy of Sciences Bratislava Slovak Republic

Department of Physical Performance Norwegian School of Sport Sciences Oslo Norway

Department of Urology University Hospital Bratislava Slovak Republic

Institute of Pathophysiology Faculty of Medicine Comenius University in Bratislava Bratislava Slovak Republic

Relation between testosterone levels and body composition, physical functioning and selected biochemical parameters in adult males

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$a Relation between testosterone levels and body composition, physical functioning and selected biochemical parameters in adult males / $c Milan Sedliak, Michal Kralik, Jan Cvecka, Gabriel Buzgo, Matus Putala, Barbara Ukropcová, Jozef, Ukropec, Zdenko Kilinger, Juraj Payer, Boris Kollárik, Peter Bujdak, Truls Raastad

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$a Relation between testosterone levels and body composition, physical functioning and selected biochemical parameters in adult males

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$a Introduction: The objective of the study was to examine the relationship between the values of selected parameters of physical function, body composition, body mass index (BMI) and biochemical markers of metabolic health with the total testosterone (TT) levels in adult males. We aimed to analyse the correlation between these values and variations in the TT levels. Methods: A total of 17 subjects (age = 50.2 ± 8.1 years, TT = 11.4 ± 3.8 nmol/l) were included in the study. Subjects were tested on physical function (1RM on leg press, bench-press, handgrip, VO2max), body composition (DXA), biochemical parameters (morning fasting blood samples). Results: TT was inversely correlated with abdominal circumference (AC) (p < 0.01) and with overall body fat, measured in kg (p < 0.01). On a biochemical level, significant correlations were found between TT and insulin (p < 0.01), and TT and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.01). Physical function, muscle strength or lean mass were not significantly correlated with TT. Conclusion: The main finding of this study was that testosterone levels had a strong inverse correlation with abdominal circumference and total body fat mass. On metabolic level, strong inverse correlation was also found between TT with insulin and TT with HOMA-IR. However, we did not find statistically significant correlation between total testosterone levels and lean mass, muscle strength or physical function in middle aged males.

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$a Raastad, Truls $u Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway

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