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Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children
D. Pastucha, R. Filipčíková, D. Horáková, K. Azeem, J. Malinčíková, M. Kocvrlich,
Language English Country Germany
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 2014-05-01 to 2017-12-31
Health & Medicine (ProQuest)
from 2014-05-01 to 2017-12-31
- MeSH
- Models, Biological MeSH
- Child MeSH
- Homeostasis MeSH
- Insulin Resistance * MeSH
- Blood Glucose metabolism MeSH
- Humans MeSH
- Metabolic Syndrome epidemiology MeSH
- Adolescent MeSH
- Pediatric Obesity complications epidemiology physiopathology MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
OBJECTIVE: The study aimed to determine the incidence of metabolic syndrome (MS) in a group of Czech obese children, to evaluate the incidence of insulin resistance according to HOMA-IR in this group, and to consider the diagnostic value of HOMA-IR in early MS detection in obese children using the logistic regression models for analyzing the relations between HOMA IR and MS. SUBJECTS AND METHODS: Anthropometric and laboratory examinations were performed in a group of 274 obese children aged 10-17 years. RESULTS: MS was established in 102 subjects (37%). The presence of insulin resistance according to HOMA-IR >3.16 was ascertained in 53% of the subjects. HOMA-IR limit was exceeded by 70% in the MS (+) group and by 43% in children in the MS (-) (p<0.0001) category. CONCLUSION: The relatively high incidence of insulin resistance in obese children without MS questions the prevailing diagnostic criteria of, perhaps, falsely excluding some cases of, MS.
References provided by Crossref.org
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- $a OBJECTIVE: The study aimed to determine the incidence of metabolic syndrome (MS) in a group of Czech obese children, to evaluate the incidence of insulin resistance according to HOMA-IR in this group, and to consider the diagnostic value of HOMA-IR in early MS detection in obese children using the logistic regression models for analyzing the relations between HOMA IR and MS. SUBJECTS AND METHODS: Anthropometric and laboratory examinations were performed in a group of 274 obese children aged 10-17 years. RESULTS: MS was established in 102 subjects (37%). The presence of insulin resistance according to HOMA-IR >3.16 was ascertained in 53% of the subjects. HOMA-IR limit was exceeded by 70% in the MS (+) group and by 43% in children in the MS (-) (p<0.0001) category. CONCLUSION: The relatively high incidence of insulin resistance in obese children without MS questions the prevailing diagnostic criteria of, perhaps, falsely excluding some cases of, MS.
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