Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: a crossover study

Frantisek Novak, Marek Vecka, Eva Meisnerova, Stanislav Sevela, Lucie Vavrova, Jana Rychlikova, Ludmila Dolezalova, Denisa Myslivcova, Ales Zak, Libor Vitek, Olga Novakova

. 2019 ; 72 () : 70-79.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu práce podpořená grantem, klinická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc20016612

Grantová podpora
NV15-28745A MZ0 CEP - Centrální evidence projektů

Long-chain n-3 polyunsaturated fatty acids modulate immune cell functions. The primary objective of this study was to evaluate the impact of different lipid emulsions (LEs) with supplemented doses of fish oil (FO) on serum cytokine concentration and in vitro cytokine production in patients with intestinal failure on home parenteral nutrition (HPNPs). We hypothesized that FO supplementation would diminish lipopolysaccharide (LPS)-stimulated cytokine production. Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. After this cycle, the patients were randomized to subsequently receive 1 cycle with Lipoplus and 1 cycle with ClinOleic for 6 weeks or vice versa plus 4 weeks of added Omegaven after each cycle in a crossover design. Comparison of the baseline LE regimens showed lower LPS-stimulated production of IL-1β in the HPNPs on Lipoplus than on the Smoflipid and ClinOleic regimens, as well as lower IL-8 compared to the Smoflipid regimen. Omegaven reduced IL-8 concentration in serum under the Lipoplus regimen and diminished LPS-stimulated production of IL-1β under the Smoflipid and ClinOleic. IL-6 and TNF-α production was depressed only in those on Smoflipid. Irrespective of the LE used, the HPNPs compared to the healthy controls showed higher IL-6, IL-8, and TNF-α concentrations in serum and LPS-stimulated production of IL-6 as well as lower n-6/n-3 long-chain polyunsaturated fatty acids in the erythrocyte phospholipids. LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. In conclusion, FO-supplemented parenteral nutrition suppresses in vitro cytokine production.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20016612
003      
CZ-PrNML
005      
20240624085431.0
007      
ta
008      
201023s2019 xxu f 000 0|eng||
009      
AR
024    0_
$a 10.1016/j.nutres.2019.10.004 $2 DOI
035    __
$a (Pubmed)31759770
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Novák, František, $d 1971- $7 mzk2006324218 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
245    10
$a Fish oil supplementation with various lipid emulsions suppresses in vitro cytokine release in home parenteral nutrition patients: a crossover study / $c Frantisek Novak, Marek Vecka, Eva Meisnerova, Stanislav Sevela, Lucie Vavrova, Jana Rychlikova, Ludmila Dolezalova, Denisa Myslivcova, Ales Zak, Libor Vitek, Olga Novakova
520    9_
$a Long-chain n-3 polyunsaturated fatty acids modulate immune cell functions. The primary objective of this study was to evaluate the impact of different lipid emulsions (LEs) with supplemented doses of fish oil (FO) on serum cytokine concentration and in vitro cytokine production in patients with intestinal failure on home parenteral nutrition (HPNPs). We hypothesized that FO supplementation would diminish lipopolysaccharide (LPS)-stimulated cytokine production. Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. After this cycle, the patients were randomized to subsequently receive 1 cycle with Lipoplus and 1 cycle with ClinOleic for 6 weeks or vice versa plus 4 weeks of added Omegaven after each cycle in a crossover design. Comparison of the baseline LE regimens showed lower LPS-stimulated production of IL-1β in the HPNPs on Lipoplus than on the Smoflipid and ClinOleic regimens, as well as lower IL-8 compared to the Smoflipid regimen. Omegaven reduced IL-8 concentration in serum under the Lipoplus regimen and diminished LPS-stimulated production of IL-1β under the Smoflipid and ClinOleic. IL-6 and TNF-α production was depressed only in those on Smoflipid. Irrespective of the LE used, the HPNPs compared to the healthy controls showed higher IL-6, IL-8, and TNF-α concentrations in serum and LPS-stimulated production of IL-6 as well as lower n-6/n-3 long-chain polyunsaturated fatty acids in the erythrocyte phospholipids. LPS-stimulated production of IL-6 correlated negatively with the parenteral dose of eicosapentaenoic acid + docosahexaenoic acid. In conclusion, FO-supplemented parenteral nutrition suppresses in vitro cytokine production.
650    17
$a parenterální výživa doma $x metody $7 D016331 $2 czmesh
650    17
$a rybí oleje $x imunologie $7 D005395 $2 czmesh
650    _7
$a potravní doplňky $7 D019587 $2 czmesh
650    _7
$a cytokiny $x krev $7 D016207 $2 czmesh
650    _7
$a tukové emulze intravenózní $7 D005217 $2 czmesh
650    _7
$a lipopolysacharidy $x imunologie $7 D008070 $2 czmesh
650    _7
$a zánět $7 D007249 $2 czmesh
650    _7
$a klinické křížové studie $7 D018592 $2 czmesh
650    _7
$a imunomodulace $7 D056747 $2 czmesh
650    _7
$a imunologické faktory $7 D007155 $2 czmesh
650    _7
$a techniky in vitro $7 D066298 $2 czmesh
650    _7
$a dospělí $7 D000328 $2 czmesh
650    _7
$a lidé $7 D006801 $2 czmesh
655    _7
$a práce podpořená grantem $7 D013485 $2 czmesh
655    _7
$a klinická studie $7 D000068397 $2 czmesh
700    1_
$a Vecka, Marek, $d 1976- $7 xx0076497 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Meisnerová, Eva $7 xx0116141 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Ševela, Stanislav $7 xx0217297 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Vávrová, Lucie $7 xx0142642 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Rychlíková, Jana $7 xx0211877 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Doležalová, Ludmila $7 xx0061803 $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
700    1_
$a Myslivcová, Denisa $7 xx0139740 $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic
700    1_
$a Žák, Aleš, $d 1951- $7 mzk2007382175 $u Charles University, 1st Faculty of Medicine and General University Hospital, 4th Department of Internal Medicine, Prague, Czech Republic
700    1_
$a Vítek, Libor, $d 1969- $7 xx0035071 $u Charles University, 1st Faculty of Medicine and General University Hospital, Institute of Medical Biochemistry and Laboratory Diagnostics, Prague, Czech Republic
700    1_
$a Nováková, Olga $u Charles University in Prague, Faculty of Science, Department of Physiology, Prague, Czech Republic; Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
773    0_
$t Nutrition research $x 0271-5317 $g Roč. 72 (2019), s. 70-79 $w MED00008649
910    __
$a ABA008 $y 0 $z 0
990    __
$a 20201023105307 $b ABA008
991    __
$a 20240624085429 $b ABA008
999    __
$a kom $b bmc $g 1575323 $s 1106789
BAS    __
$a 3
BMC    __
$a 2019 $b 72 $d 70-79 $x MED00008649 $i 0271-5317 $m Nutrition research
GRA    __
$a NV15-28745A $p MZ0
LZP    __
$c NLK120 $d 20240620 $a 2020-grant

Najít záznam

Citační ukazatele

Možnosti archivace