Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Flavonoids in Cancer Metastasis

A. Liskova, L. Koklesova, M. Samec, K. Smejkal, SM. Samuel, E. Varghese, M. Abotaleb, K. Biringer, E. Kudela, J. Danko, M. Shakibaei, TK. Kwon, D. Büsselberg, P. Kubatka,

. 2020 ; 12 (6) : . [pub] 20200608

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc20019066

Grant support
NPRP 11S-1214-170101 Qatar National Research Fund
VEGA 1/0136/19 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
ITMS: 26220120053 European Regional Development Fund

Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20019066
003      
CZ-PrNML
005      
20201123124531.0
007      
ta
008      
201103s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/cancers12061498 $2 doi
035    __
$a (PubMed)32521759
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Liskova, Alena $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
245    10
$a Flavonoids in Cancer Metastasis / $c A. Liskova, L. Koklesova, M. Samec, K. Smejkal, SM. Samuel, E. Varghese, M. Abotaleb, K. Biringer, E. Kudela, J. Danko, M. Shakibaei, TK. Kwon, D. Büsselberg, P. Kubatka,
520    9_
$a Metastasis represents a serious complication in the treatment of cancer. Flavonoids are plant secondary metabolites exerting various health beneficiary effects. The effects of flavonoids against cancer are associated not only with early stages of the cancer process, but also with cancer progression and spread into distant sites. Flavonoids showed potent anti-cancer effects against various cancer models in vitro and in vivo, mediated via regulation of key signaling pathways involved in the migration and invasion of cancer cells and metastatic progression, including key regulators of epithelial-mesenchymal transition or regulatory molecules such as MMPs, uPA/uPAR, TGF-β and other contributors of the complex process of metastatic spread. Moreover, flavonoids modulated also the expression of genes associated with the progression of cancer and improved inflammatory status, a part of the complex process involved in the development of metastasis. Flavonoids also documented clear potential to improve the anti-cancer effectiveness of conventional chemotherapeutic agents. Most importantly, flavonoids represent environmentally-friendly and cost-effective substances; moreover, a wide spectrum of different flavonoids demonstrated safety and minimal side effects during long-termed administration. In addition, the bioavailability of flavonoids can be improved by their conjugation with metal ions or structural modifications by radiation. In conclusion, anti-cancer effects of flavonoids, targeting all phases of carcinogenesis including metastatic progression, should be implemented into clinical cancer research in order to strengthen their potential use in the future targeted prevention and therapy of cancer in high-risk individuals or patients with aggressive cancer disease with metastatic potential.
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Koklesova, Lenka $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
700    1_
$a Samec, Marek $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
700    1_
$a Smejkal, Karel $u Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 61242 Brno, Czech Republic.
700    1_
$a Samuel, Samson Mathews $u Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
700    1_
$a Varghese, Elizabeth $u Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
700    1_
$a Abotaleb, Mariam $u Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
700    1_
$a Biringer, Kamil $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
700    1_
$a Kudela, Erik $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
700    1_
$a Danko, Jan $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
700    1_
$a Shakibaei, Mehdi $u Musculoskeletal Research Group and Tumour Biology, Chair of Vegetative Anatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, D-80336 Munich, Germany.
700    1_
$a Kwon, Taeg Kyu $u Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu 426 01, Korea.
700    1_
$a Büsselberg, Dietrich $u Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha 24144, Qatar.
700    1_
$a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
773    0_
$w MED00173178 $t Cancers $x 2072-6694 $g Roč. 12, č. 6 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32521759 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201103 $b ABA008
991    __
$a 20201123124529 $b ABA008
999    __
$a ind $b bmc $g 1585846 $s 1109264
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 12 $c 6 $e 20200608 $i 2072-6694 $m Cancers $n Cancers $x MED00173178
GRA    __
$a NPRP 11S-1214-170101 $p Qatar National Research Fund
GRA    __
$a VEGA 1/0136/19 $p Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
GRA    __
$a ITMS: 26220120053 $p European Regional Development Fund
LZP    __
$a Pubmed-20201103

Find record

Citation metrics

Archiving options