BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system. The cause of MS is still unknown, and the role of innate immunity is still poorly understood. OBJECTIVE: The goal of this study was to understand whether, compared to healthy controls, the elements of innate immunity are altered in the blood of MS patients in the remitting phase. METHODS: A total of 77 naïve MS patients and 50 healthy controls were included in this cohort study. Peripheral blood samples were collected and analyzed. All the calculations were performed with the statistical system R (r-project.org). RESULTS: The results showed that MS patients had significantly lower relative representations of granulocytes than healthy controls, while the relative representations of monocytes remained unchanged. CD64- and PD-L1-positive granulocytes exhibited a nonsignificant decreasing trend, while granulocytes with other membrane markers remained noticeably unchanged. CONCLUSION: The results of this study suggest that studies of the causes of MS and its treatment should also be focused on the elements of the innate immune response.

Department of Chemistry Faculty of Science University of Hradec Králové Rokitanského 62 500 03 Hradec Kralove Czech Republic Biomedical Research Center University Hospital Hradec Kralove Sokolská 581 500 05 Hradec Kralove Czech Republic

Department of Clinical Immunology and Allergology University Hospital Hradec Králové Sokolská 581 500 05 Hradec Kralove Czech Republic

Department of Neurology Faculty of Medicine and University Hospital Hradec Králové Charles University Prague Sokolská 581 500 05 Hradec Kralove Czech Republic

Department of Neurology Faculty of Medicine and University Hospital Hradec Králové Charles University Prague Sokolská 581 500 05 Hradec Kralove Czech Republic Memory Clinic Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital 5 Úvalu 84 150 06 Prague Czech Republic

Citace poskytuje Crossref.org