-
Je něco špatně v tomto záznamu ?
A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium
K. Oppedal, D. Ferreira, L. Cavallin, AW. Lemstra, M. Ten Kate, A. Padovani, I. Rektorova, L. Bonanni, LO. Wahlund, K. Engedal, F. Nobili, M. Kramberger, JP. Taylor, J. Hort, J. Snædal, F. Blanc, Z. Walker, A. Antonini, E. Westman, D. Aarsland,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
Grantová podpora
U01 AG024904
NIA NIH HHS - United States
- MeSH
- Alzheimerova nemoc diagnostické zobrazování patologie MeSH
- atrofie MeSH
- demence s Lewyho tělísky diagnostické zobrazování patologie MeSH
- diferenciální diagnóza MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozková kůra diagnostické zobrazování patologie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- testy pro posouzení mentálních funkcí a demence MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Geografické názvy
- Evropa MeSH
INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
Centre for Age Related Medicine Stavanger University Hospital Stavanger Norway
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Neurology and Alzheimercenter VU Universisty Medical Center Amsterdam Netherlands
Department of Radiology Karolinska University Hospital Stockholm Sweden
Department of Radiology Stavanger University Hospital Stavanger Norway
Institute of Neuroscience Newcastle University Newcastle upon Tyne United Kingdom
Institute of Psychiatry Psychology and Neuroscience King's College London London UK
International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
Landspitali University Hospital Reykjavik Iceland
Neurology Unit Department o Clinical and Experimental Sciences University of Brescia Brescia Italy
University of Strasbourg and French National Centre for Scientific Research ICONE Strasbourg France
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20022848
- 003
- CZ-PrNML
- 005
- 20201214124855.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.jalz.2018.09.011 $2 doi
- 035 __
- $a (PubMed)30439333
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Oppedal, Ketil $u Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Department of Radiology, Stavanger University Hospital, Stavanger, Norway.
- 245 12
- $a A signature pattern of cortical atrophy in dementia with Lewy bodies: A study on 333 patients from the European DLB consortium / $c K. Oppedal, D. Ferreira, L. Cavallin, AW. Lemstra, M. Ten Kate, A. Padovani, I. Rektorova, L. Bonanni, LO. Wahlund, K. Engedal, F. Nobili, M. Kramberger, JP. Taylor, J. Hort, J. Snædal, F. Blanc, Z. Walker, A. Antonini, E. Westman, D. Aarsland, Alzheimer's Disease Neuroimaging Initiative,
- 520 9_
- $a INTRODUCTION: We explored regional brain atrophy patterns and their clinical correlates in dementia with Lewy bodies (DLB). METHODS: In this multicentre study, we included a total of 333 patients with DLB, 352 patients with Alzheimer's disease (AD), and 233 normal controls and used medial temporal lobe atrophy, posterior atrophy, and frontal atrophy (GCA-F) visual rating scales. Patients were classified according to four atrophy patterns. RESULTS: Patients with DLB had higher scores on all the three atrophy scales than normal controls but had less medial temporal lobe atrophy than those with AD (all P values < .001). A signature hippocampal-sparing pattern of regional atrophy was observed in DLB. The magnetic resonance imaging measures showed 65% ability to discriminate between DLB and AD and marginally contributed to the discrimination over and above the core clinical features. DISCUSSION: The most common pattern of atrophy of DLB was hippocampal-sparing. Future studies should explore whether comorbid AD pathology underlies the atrophy patterns seen in DLB.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a Alzheimerova nemoc $x diagnostické zobrazování $x patologie $7 D000544
- 650 _2
- $a atrofie $7 D001284
- 650 _2
- $a mozková kůra $x diagnostické zobrazování $x patologie $7 D002540
- 650 _2
- $a diferenciální diagnóza $7 D003937
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a demence s Lewyho tělísky $x diagnostické zobrazování $x patologie $7 D020961
- 650 _2
- $a magnetická rezonanční tomografie $7 D008279
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a testy pro posouzení mentálních funkcí a demence $7 D000073216
- 650 _2
- $a retrospektivní studie $7 D012189
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a Research Support, U.S. Gov't, Non-P.H.S. $7 D013486
- 700 1_
- $a Ferreira, Daniel $u Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Cavallin, Lena $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Lemstra, Afina W $u Department of Neurology and Alzheimercenter, VU Universisty Medical Center, Amsterdam, Netherlands.
- 700 1_
- $a Ten Kate, Mara $u Department of Neurology and Alzheimercenter, VU Universisty Medical Center, Amsterdam, Netherlands.
- 700 1_
- $a Padovani, Alessandro $u Neurology Unit, Department o Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
- 700 1_
- $a Rektorova, Irena $u 1(st) Department of Neurology, Medical Faculty, St. Anne's Hospital and CEITEC, Masaryk University, Brno, Czech Republic.
- 700 1_
- $a Bonanni, Laura $u Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.
- 700 1_
- $a Wahlund, Lars-Olof $u Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Engedal, Knut $u Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust and Oslo University Hospital, Oslo, Norway.
- 700 1_
- $a Nobili, Flavio $u Department of Neuroscience (DINOGMI), University of Genoa and Neurology Clinics, Polyclinic San Martino Hospital, Genoa, Italy.
- 700 1_
- $a Kramberger, Milica $u Department of Neurology, University Medical Centre Ljubljana, Medical faculty, University of Ljubljana, Slovenia.
- 700 1_
- $a Taylor, John-Paul $u Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
- 700 1_
- $a Hort, Jakub $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
- 700 1_
- $a Snædal, Jon $u Landspitali University Hospital, Reykjavik, Iceland.
- 700 1_
- $a Blanc, Frederic $u Day Hospital of Geriatrics, Memory Resource and Research Centre (CM2R) of Strasbourg, Department of Geriatrics, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and French National Centre for Scientific Research (CNRS), ICube Laboratory and Fédération de Médecine Translationnelle de Strasbourg (FMTS), Team Imagerie Multimodale Intégrative en Santé (IMIS)/ICONE, Strasbourg, France.
- 700 1_
- $a Walker, Zuzana $u University College London, London & Essex Partnership University NHS Foundation Trust, United Kingdom.
- 700 1_
- $a Antonini, Angelo $u Department of Neuroscience, University of Padua, Padua & Fondazione Ospedale San Camillo, Venezia, Venice, Italy.
- 700 1_
- $a Westman, Eric $u Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
- 700 1_
- $a Aarsland, Dag $u Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address: daarsland@gmail.com.
- 710 2_
- $a Alzheimer's Disease Neuroimaging Initiative
- 773 0_
- $w MED00166531 $t Alzheimer's & dementia : the journal of the Alzheimer's Association $x 1552-5279 $g Roč. 15, č. 3 (2019), s. 400-409
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30439333 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201214124855 $b ABA008
- 999 __
- $a ok $b bmc $g 1595167 $s 1113524
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 15 $c 3 $d 400-409 $e 20181112 $i 1552-5279 $m Alzheimer's & dementia $n Alzheimers Dement $x MED00166531
- GRA __
- $a U01 AG024904 $p NIA NIH HHS $2 United States
- LZP __
- $a Pubmed-20201125
