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Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications

K. Smetana, J. Brábek,

. 2020 ; 34 (3 Suppl) : 1589-1592. [pub] -

Language English Country Greece

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc20023018

COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.

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