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Does Neuraxial Anesthesia as General Anesthesia Damage DNA? A Pilot Study in Patients Undergoing Orthopedic Traumatological Surgery

M. Kucharova, D. Astapenko, V. Zubanova, M. Koscakova, R. Stetina, Z. Zadak, M. Hronek,

. 2019 ; 21 (1) : . [pub] 20191220

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20023315

Grant support
MH CZ - DRO UHHK 00179906 PROGRES Q42

The human organism is exposed daily to many endogenous and exogenous substances that are the source of oxidative damage. Oxidative damage is one of the most frequent types of cell component damage, leading to oxidation of lipids, proteins, and the DNA molecule. The predominance of these damaging processes may later be responsible for human diseases such as cancer, neurodegenerative disease, or heart failure. Anesthetics undoubtedly belong to the group of substances harming DNA integrity. The goal of this pilot study is to evaluate the range of DNA damage by general and neuraxial spinal anesthesia in two groups of patients undergoing orthopedic traumatological surgery. Each group contained 20 patients, and blood samples were collected before and after anesthesia; the degree of DNA damage was evaluated by the comet assay method. Our results suggest that general anesthesia can cause statistically significant damage to the DNA of patients, whereas neuraxial anesthesia has no negative influence.

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$a Kucharova, Monika $u Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. Department of Research and Development, University Hospital in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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$a Does Neuraxial Anesthesia as General Anesthesia Damage DNA? A Pilot Study in Patients Undergoing Orthopedic Traumatological Surgery / $c M. Kucharova, D. Astapenko, V. Zubanova, M. Koscakova, R. Stetina, Z. Zadak, M. Hronek,
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$a The human organism is exposed daily to many endogenous and exogenous substances that are the source of oxidative damage. Oxidative damage is one of the most frequent types of cell component damage, leading to oxidation of lipids, proteins, and the DNA molecule. The predominance of these damaging processes may later be responsible for human diseases such as cancer, neurodegenerative disease, or heart failure. Anesthetics undoubtedly belong to the group of substances harming DNA integrity. The goal of this pilot study is to evaluate the range of DNA damage by general and neuraxial spinal anesthesia in two groups of patients undergoing orthopedic traumatological surgery. Each group contained 20 patients, and blood samples were collected before and after anesthesia; the degree of DNA damage was evaluated by the comet assay method. Our results suggest that general anesthesia can cause statistically significant damage to the DNA of patients, whereas neuraxial anesthesia has no negative influence.
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$a Astapenko, David $u Department of Research and Development, University Hospital in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Department of Anesthesiology, Resuscitation and Intensive Medicine, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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$a Zubanova, Veronika $u Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. Institute for Clinical Biochemistry and Diagnostics, Charles University, Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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$a Koscakova, Maria $u Department of Biophysics and Physical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
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$a Stetina, Rudolf $u Department of Research and Development, University Hospital in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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$a Zadak, Zdenek $u Department of Research and Development, University Hospital in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
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$a Hronek, Miloslav $u Department of Research and Development, University Hospital in Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, Zborovska 2089, 500 03 Hradec Kralove, Czech Republic.
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