Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Terbinafine-loaded branched PLGA-based cationic nanoparticles with modifiable properties

J. Martiska, E. Snejdrova, M. Drastik, L. Matysova, M. Dittrich, J. Loskot, P. Jilek,

. 2019 ; 24 (10) : 1308-1316. [pub] 20190925

Language English Country Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc20023440

Although the systemic administration of terbinafine is quite well tolerated, topical treatment of the local infections is often preferred. New formulation strategies in topical antifungal therapy represent the polymeric nanoparticles (NPs). We successfully employed the originally synthesized PLGA derivatives of branched architectures of various molar masses, branching ratio, and high number of terminal hydroxyl or carboxyl groups for compounding of terbinafine loaded nanoparticles by nanoprecipitation method. Employing the polymers with tailored properties allowed us to formulate the NPs with desired particle size, loading capacity for drug, mucoadhesive properties, and drug release profile. The hydrophobicity and the polyester concentration revealed the main impact on the NPs size ranging from 100 to 600 nm. The stability of the nanosuspension is demonstrated by zeta potential >25 mV, and polydispersity index values <0.2. We used terbinafine in its less dissolved form of the base to increase the drug loading and delay the release. Cationic surfactant as stabilizer give the NPs high positive surface charge enhancing the adhesion to the mucosal surfaces. All formulations provided prolonged sustained release of terbinafine for several days. Antimicrobial potential has been proven by agar-well diffusion method.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023440
003      
CZ-PrNML
005      
20201214130040.0
007      
ta
008      
201125s2019 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1080/10837450.2019.1667387 $2 doi
035    __
$a (PubMed)31509046
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Martiska, Juraj $u Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
245    10
$a Terbinafine-loaded branched PLGA-based cationic nanoparticles with modifiable properties / $c J. Martiska, E. Snejdrova, M. Drastik, L. Matysova, M. Dittrich, J. Loskot, P. Jilek,
520    9_
$a Although the systemic administration of terbinafine is quite well tolerated, topical treatment of the local infections is often preferred. New formulation strategies in topical antifungal therapy represent the polymeric nanoparticles (NPs). We successfully employed the originally synthesized PLGA derivatives of branched architectures of various molar masses, branching ratio, and high number of terminal hydroxyl or carboxyl groups for compounding of terbinafine loaded nanoparticles by nanoprecipitation method. Employing the polymers with tailored properties allowed us to formulate the NPs with desired particle size, loading capacity for drug, mucoadhesive properties, and drug release profile. The hydrophobicity and the polyester concentration revealed the main impact on the NPs size ranging from 100 to 600 nm. The stability of the nanosuspension is demonstrated by zeta potential >25 mV, and polydispersity index values <0.2. We used terbinafine in its less dissolved form of the base to increase the drug loading and delay the release. Cationic surfactant as stabilizer give the NPs high positive surface charge enhancing the adhesion to the mucosal surfaces. All formulations provided prolonged sustained release of terbinafine for several days. Antimicrobial potential has been proven by agar-well diffusion method.
650    _2
$a aplikace lokální $7 D000287
650    _2
$a antifungální látky $x aplikace a dávkování $x chemie $7 D000935
650    _2
$a kationty $7 D002412
650    _2
$a nosiče léků $x chemie $7 D004337
650    _2
$a příprava léků $x metody $7 D004339
650    _2
$a uvolňování léčiv $7 D065546
650    _2
$a hydrofobní a hydrofilní interakce $7 D057927
650    _2
$a nanočástice $x chemie $7 D053758
650    _2
$a velikost částic $7 D010316
650    _2
$a kopolymer kyseliny glykolové a mléčné $x chemie $7 D000077182
650    _2
$a rozpustnost $7 D012995
650    _2
$a povrchové vlastnosti $7 D013499
650    _2
$a povrchově aktivní látky $x chemie $7 D013501
650    _2
$a terbinafin $x aplikace a dávkování $x chemie $7 D000077291
650    _2
$a viskozita $7 D014783
655    _2
$a časopisecké články $7 D016428
700    1_
$a Snejdrova, Eva $u Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
700    1_
$a Drastik, Martin $u Department of Biophysics and Physical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
700    1_
$a Matysova, Ludmila $u Department of Analytical Chemistry, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
700    1_
$a Dittrich, Milan $u Department of Pharmaceutical Technology, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
700    1_
$a Loskot, Jan $u Department of Physics, Faculty of Science, University of Hradec Kralove , Hradec Kralove , Czech Republic.
700    1_
$a Jilek, Petr $u Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University , Prague , Czech Republic.
773    0_
$w MED00004889 $t Pharmaceutical development and technology $x 1097-9867 $g Roč. 24, č. 10 (2019), s. 1308-1316
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31509046 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214130040 $b ABA008
999    __
$a ok $b bmc $g 1595759 $s 1114116
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 24 $c 10 $d 1308-1316 $e 20190925 $i 1097-9867 $m Pharmaceutical development and technology $n Pharm Dev Technol $x MED00004889
LZP    __
$a Pubmed-20201125

Find record

Citation metrics

Archiving options