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Neurobiology and therapeutic utility of neurotoxins targeting postsynaptic mechanisms of neuromuscular transmission
NM. Ayvazyan, VB. O'Leary, JO. Dolly, SV. Ovsepian,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- lidé MeSH
- modely neurologické MeSH
- nervosvalové spojení fyziologie MeSH
- nervový přenos fyziologie MeSH
- neurotoxiny farmakologie terapeutické užití MeSH
- postsynaptická denzita účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The neuromuscular junction (NMJ) is the principal site for the translation of motor neurochemical signals to muscle activity. Therefore, the release and sensing machinery of acetylcholine (ACh) along with muscle contraction are two of the main targets of natural toxins and pathogens, causing paralysis. Given pharmacology and medical advances, the active ingredients of toxins that target postsynaptic mechanisms have become of major interest, showing promise as drug leads. Herein, we review key facets of prevalent toxins modulating the mechanisms of ACh sensing and generation of the postsynaptic response, with muscle contraction. We consider the correlation between their outstanding selectivity and potency plus effects on motor function, and discuss emerging data advocating their usage for the development of therapies alleviating neuromuscular dysfunction.
International Centre for Neurotherapeutics Dublin City University Dublin Ireland
The National Institute of Mental Health Topolová 748 Klecany Czech Republic
Citace poskytuje Crossref.org
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- $a Ayvazyan, Naira M $u Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia. Electronic address: taipan@ysu.am.
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- $a The neuromuscular junction (NMJ) is the principal site for the translation of motor neurochemical signals to muscle activity. Therefore, the release and sensing machinery of acetylcholine (ACh) along with muscle contraction are two of the main targets of natural toxins and pathogens, causing paralysis. Given pharmacology and medical advances, the active ingredients of toxins that target postsynaptic mechanisms have become of major interest, showing promise as drug leads. Herein, we review key facets of prevalent toxins modulating the mechanisms of ACh sensing and generation of the postsynaptic response, with muscle contraction. We consider the correlation between their outstanding selectivity and potency plus effects on motor function, and discuss emerging data advocating their usage for the development of therapies alleviating neuromuscular dysfunction.
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- $a Ovsepian, Saak V $u International Centre for Neurotherapeutics, Dublin City University, Dublin, Ireland; The National Institute of Mental Health, Topolová 748, Klecany, Czech Republic; Department of Psychiatry and Medical Psychology, Third Faculty of Medicine, Charles University, Ruská 87, 100 00, Praha 10, Czech Republic. Electronic address: saak.ovsepian@gmail.com.
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