Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.

1st Faculty of Medicine Institute of Hygiene and Epidemiology Charles University Prague Czech Republic

2nd Faculty of Medicine Institute of Public Health and Preventive Medicine Charles University Prague Czech Republic

Brigham and Women's Hospital and VA Boston Boston MA USA

Brown University Providence RI USA

Cancer Epidemiology and Intelligence Division Cancer Council of Victoria 615 St Kilda Road Melbourne VIC 3004 Australia

Cancer Epidemiology and Intelligence Division Cancer Council of Victoria 615 St Kilda Road Melbourne VIC 3004 Australia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health The University of Melbourne Parkville Victoria 3010 Australia

Cancer Epidemiology and Intelligence Division Cancer Council of Victoria 615 St Kilda Road Melbourne VIC 3004 Australia Inserm U1018 Center for Research in Epidemiology and Population Health Facultés de Medicine Université Paris Saclay Université Paris Sud UVSQ Gustave Roussy 114 rue Edouard Vaillant 94805 Villejuif Cedex France

Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle WA USA

Carol Davila University of Medicine and Pharmacy Th Burghele Hospital Bucharest Romania

Center 'Bioengineering' of the Russian Academy of Sciences Moscow Russian Federation Kurchatov Scientific Center Moscow Russian Federation

Centre National de Recherche en Génomique Humaine Institut de biologie François Jacob CEA Evry France

Centre National de Recherche en Génomique Humaine Institut de biologie François Jacob CEA Evry France Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain Paris France

Dana Farber Cancer Institute Bostan MA USA

Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic

Department of Computational Biology St Jude Children's Research Hospital Memphis TN USA

Department of Epidemiology and Biostatistics School of Public Health Indiana University Bloomington Bloomington IN USA

Department of Epidemiology Division of Cancer Prevention and Population Sciences The University of Texas MD Anderson Cancer Center Houston TX USA

Department of Epidemiology Nofer Institute of Occupational Medicine Lodz Poland

Department of Oncology University of Cambridge Cambridge UK Department of Public Health and Primary Care University of Cambridge Cambridge UK

Department of Preventive Medicine Faculty of Medicine Palacky University Olomouc Czech Republic Faculty of Health Sciences Palacky University Olomouc Czech Republic

Department of Public Health Section for Epidemiology Aarhus University Aarhus C Denmark

Department of Surgical and Perioperative Sciences Urology and Andrology Umeå University Umeå Sweden

Department of Urology University Hospital Dr D Misovic Clinical Center Belgrade Serbia

Dipartimento di Medicina Clinica e Chirurgia Federico 2 University Naples Italy

Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Department Health and Human Services Bethesda MD USA

Division of Urology Spectrum Health Grand Rapids MI USA

Division of Urology Spectrum Health Grand Rapids MI USA College of Human Medicine Michigan State University Grand Rapids MI USA

Faculty of Medicine School of Public Health Imperial College London London UK

Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain Paris France

Fred Hutchinson Cancer Research Center Seattle WA USA

Harvard T H Chan School of Public Health Boston MA USA

Hellenic Health Foundation Alexandroupoleos 23 Athens 11527 Greece

INSERM U946 Paris France CNRS UMR8200 Institute Gustave Roussy Villejuif France

Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden

Institute of Pathology Medical school of Belgrade Belgrade Serbia

International Agency for Research on Cancer Lyon France

International Hereditary Cancer Center Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland

Leeds Institute of Cancer and Pathology University of Leeds Cancer Research Building St James's University Hospital Leeds UK

London School of Hygiene and Tropical Medicine University of London London UK

Max Planck Institute for Demographic Research Rostock Germany

McGill University and Genome Quebec Innovation Centre Montreal Quebec Canada

National Institute for Health and Welfare Helsinki Finland

National Institute of Public Health Bucharest Romania

National Public Health Institute Budapest Hungary

Regional Authority of Public Health in BanskaBystrica BanskaBystrica Slovakia

Russian N N Blokhin Cancer Research Centre Moscow Russian Federation

Sorbonne Université GRC no 5 ONCOTYPE URO AP HP Tenon Hospital Paris France CeRePP Paris France

The M Sklodowska Curie Cancer Center and Institute of Oncology Warsaw Poland

Van Andel Research Institute Center for Cancer Genomics and Quantitative Biology Grand Rapids MI USA

Vanderbilt Ingram Cancer Center Nasville TN USA

000      

00000naa a2200000 a 4500

001      

bmc20023620

003      

CZ-PrNML

005      

20201214130614.0

007      

ta

008      

201125s2019 xxk f 000 0|eng||

009      

AR

024    7_

$a 10.1038/s41431-019-0455-9 $2 doi

035    __

$a (PubMed)31231134

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xxk

100    1_

$a Laskar, Ruhina S $u International Agency for Research on Cancer (IARC), Lyon, France.

245    10

$a Sex specific associations in genome wide association analysis of renal cell carcinoma / $c RS. Laskar, DC. Muller, P. Li, MJ. Machiela, Y. Ye, V. Gaborieau, M. Foll, JN. Hofmann, L. Colli, JN. Sampson, Z. Wang, D. Bacq-Daian, A. Boland, B. Abedi-Ardekani, G. Durand, F. Le Calvez-Kelm, N. Robinot, H. Blanche, E. Prokhortchouk, KG. Skryabin, L. Burdett, M. Yeager, S. Radojevic-Skodric, S. Savic, L. Foretova, I. Holcatova, V. Janout, D. Mates, S. Rascu, A. Mukeria, D. Zaridze, V. Bencko, C. Cybulski, E. Fabianova, V. Jinga, J. Lissowska, J. Lubinski, M. Navratilova, P. Rudnai, B. Świątkowska, S. Benhamou, G. Cancel-Tassin, O. Cussenot, A. Trichopoulou, E. Riboli, K. Overvad, S. Panico, B. Ljungberg, RT. Sitaram, GG. Giles, RL. Milne, G. Severi, F. Bruinsma, T. Fletcher, K. Koppova, SC. Larsson, A. Wolk, RE. Banks, PJ. Selby, DF. Easton, P. Pharoah, G. Andreotti, LE. Beane Freeman, S. Koutros, D. Albanes, S. Männistö, S. Weinstein, PE. Clark, TL. Edwards, L. Lipworth, H. Carol, ML. Freedman, MM. Pomerantz, E. Cho, P. Kraft, MA. Preston, KM. Wilson, J. Michael Gaziano, HD. Sesso, A. Black, ND. Freedman, WY. Huang, JG. Anema, RJ. Kahnoski, BR. Lane, SL. Noyes, D. Petillo, BT. Teh, U. Peters, E. White, GL. Anderson, L. Johnson, J. Luo, WH. Chow, LE. Moore, TK. Choueiri, C. Wood, M. Johansson, JD. McKay, KM. Brown, N. Rothman, MG. Lathrop, JF. Deleuze, X. Wu, P. Brennan, SJ. Chanock, MP. Purdue, G. Scelo,

520    9_

$a Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.

650    _2

$a karcinom z renálních buněk $x epidemiologie $x genetika $7 D002292

650    _2

$a výpočetní biologie $7 D019295

650    _2

$a ženské pohlaví $7 D005260

650    12

$a genetická predispozice k nemoci $7 D020022

650    12

$a celogenomová asociační studie $7 D055106

650    _2

$a lidé $7 D006801

650    _2

$a nádory ledvin $x epidemiologie $x genetika $7 D007680

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a odds ratio $7 D016017

650    _2

$a jednonukleotidový polymorfismus $7 D020641

650    _2

$a lokus kvantitativního znaku $7 D040641

650    _2

$a sexuální faktory $7 D012737

655    _2

$a časopisecké články $7 D016428

655    _2

$a metaanalýza $7 D017418

655    _2

$a multicentrická studie $7 D016448

655    _2

$a Research Support, N.I.H., Extramural $7 D052061

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Muller, David C $u Faculty of Medicine, School of Public Health, Imperial College London, London, UK.

700    1_

$a Li, Peng $u Max Planck Institute for Demographic Research, Rostock, Germany.

700    1_

$a Machiela, Mitchell J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Ye, Yuanqing $u Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

700    1_

$a Gaborieau, Valerie $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Foll, Matthieu $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Hofmann, Jonathan N $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Colli, Leandro $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Sampson, Joshua N $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Wang, Zhaoming $u Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

700    1_

$a Bacq-Daian, Delphine $u Centre National de Recherche en Génomique Humaine, , Institut de biologie François Jacob, CEA, Evry, France.

700    1_

$a Boland, Anne $u Centre National de Recherche en Génomique Humaine, , Institut de biologie François Jacob, CEA, Evry, France.

700    1_

$a Abedi-Ardekani, Behnoush $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Durand, Geoffroy $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Le Calvez-Kelm, Florence $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Robinot, Nivonirina $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Blanche, Helene $u Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.

700    1_

$a Prokhortchouk, Egor $u Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation. Kurchatov Scientific Center, Moscow, Russian Federation.

700    1_

$a Skryabin, Konstantin G $u Center 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation. Kurchatov Scientific Center, Moscow, Russian Federation.

700    1_

$a Burdett, Laurie $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Yeager, Meredith $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Radojevic-Skodric, Sanja $u Institute of Pathology, Medical school of Belgrade, Belgrade, Serbia.

700    1_

$a Savic, Slavisa $u Department of Urology, University Hospital "Dr D. Misovic" Clinical Center, Belgrade, Serbia.

700    1_

$a Foretova, Lenka $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

700    1_

$a Holcatova, Ivana $u 2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, Czech Republic.

700    1_

$a Janout, Vladimir $u Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic.

700    1_

$a Mates, Dana $u National Institute of Public Health, Bucharest, Romania.

700    1_

$a Rascu, Stefan $u Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.

700    1_

$a Mukeria, Anush $u Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.

700    1_

$a Zaridze, David $u Russian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.

700    1_

$a Bencko, Vladimir $u First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.

700    1_

$a Cybulski, Cezary $u International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

700    1_

$a Fabianova, Eleonora $u Regional Authority of Public Health in BanskaBystrica, BanskaBystrica, Slovakia.

700    1_

$a Jinga, Viorel $u Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.

700    1_

$a Lissowska, Jolanta $u The M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.

700    1_

$a Lubinski, Jan $u International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

700    1_

$a Navratilova, Marie $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

700    1_

$a Rudnai, Peter $u National Public Health Institute, Budapest, Hungary.

700    1_

$a Świątkowska, Beata $u Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.

700    1_

$a Benhamou, Simone $u INSERM U946, Paris, France. CNRS UMR8200, Institute Gustave Roussy, Villejuif, France.

700    1_

$a Cancel-Tassin, Geraldine $u Sorbonne Université, GRC no. 5, ONCOTYPE-URO, AP-HP, Tenon Hospital, Paris, France. CeRePP, Paris, France.

700    1_

$a Cussenot, Olivier $u Sorbonne Université, GRC no. 5, ONCOTYPE-URO, AP-HP, Tenon Hospital, Paris, France. CeRePP, Paris, France.

700    1_

$a Trichopoulou, Antonia $u Hellenic Health Foundation, Alexandroupoleos 23, Athens, 11527, Greece.

700    1_

$a Riboli, Elio $u Faculty of Medicine, School of Public Health, Imperial College London, London, UK.

700    1_

$a Overvad, Kim $u Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus C, Denmark.

700    1_

$a Panico, Salvatore $u Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.

700    1_

$a Ljungberg, Borje $u Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.

700    1_

$a Sitaram, Raviprakash T $u Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.

700    1_

$a Giles, Graham G $u Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville Victoria, 3010, Australia.

700    1_

$a Milne, Roger L $u Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville Victoria, 3010, Australia.

700    1_

$a Severi, Gianluca $u Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Facultés de Medicine, Université Paris-Saclay, Université Paris-Sud, UVSQ, Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France.

700    1_

$a Bruinsma, Fiona $u Cancer Epidemiology & Intelligence Division, Cancer Council of Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia.

700    1_

$a Fletcher, Tony $u London School of Hygiene and Tropical Medicine, University of London, London, UK.

700    1_

$a Koppova, Kvetoslava $u Regional Authority of Public Health in BanskaBystrica, BanskaBystrica, Slovakia.

700    1_

$a Larsson, Susanna C $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

700    1_

$a Wolk, Alicja $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

700    1_

$a Banks, Rosamonde E $u Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK.

700    1_

$a Selby, Peter J $u Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK.

700    1_

$a Easton, Douglas F $u Department of Oncology, University of Cambridge, Cambridge, UK. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

700    1_

$a Pharoah, Paul $u Department of Oncology, University of Cambridge, Cambridge, UK. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

700    1_

$a Andreotti, Gabriella $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Beane Freeman, Laura E $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Koutros, Stella $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Albanes, Demetrius $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Männistö, Satu $u National Institute for Health and Welfare, Helsinki, Finland.

700    1_

$a Weinstein, Stephanie $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Clark, Peter E $u Vanderbilt-Ingram Cancer Center, Nasville, TN, USA.

700    1_

$a Edwards, Todd L $u Vanderbilt-Ingram Cancer Center, Nasville, TN, USA.

700    1_

$a Lipworth, Loren $u Vanderbilt-Ingram Cancer Center, Nasville, TN, USA.

700    1_

$a Carol, Hallie $u Dana-Farber Cancer Institute, Bostan, MA, USA.

700    1_

$a Freedman, Matthew L $u Dana-Farber Cancer Institute, Bostan, MA, USA.

700    1_

$a Pomerantz, Mark M $u Dana-Farber Cancer Institute, Bostan, MA, USA.

700    1_

$a Cho, Eunyoung $u Brown University, Providence, RI, USA.

700    1_

$a Kraft, Peter $u Harvard T.H. Chan School of Public Health, Boston, MA, USA.

700    1_

$a Preston, Mark A $u Brigham and Women's Hospital and VA Boston, Boston, MA, USA.

700    1_

$a Wilson, Kathryn M $u Harvard T.H. Chan School of Public Health, Boston, MA, USA.

700    1_

$a Michael Gaziano, J $u Brigham and Women's Hospital and VA Boston, Boston, MA, USA.

700    1_

$a Sesso, Howard D $u Harvard T.H. Chan School of Public Health, Boston, MA, USA.

700    1_

$a Black, Amanda $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Freedman, Neal D $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Huang, Wen-Yi $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Anema, John G $u Division of Urology, Spectrum Health, Grand Rapids, MI, USA.

700    1_

$a Kahnoski, Richard J $u Division of Urology, Spectrum Health, Grand Rapids, MI, USA.

700    1_

$a Lane, Brian R $u Division of Urology, Spectrum Health, Grand Rapids, MI, USA. College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.

700    1_

$a Noyes, Sabrina L $u Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.

700    1_

$a Petillo, David $u Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.

700    1_

$a Teh, Bin Tean $u Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.

700    1_

$a Peters, Ulrike $u Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

700    1_

$a White, Emily $u Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

700    1_

$a Anderson, Garnet L $u Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

700    1_

$a Johnson, Lisa $u Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

700    1_

$a Luo, Juhua $u Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, IN, USA.

700    1_

$a Chow, Wong-Ho $u Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

700    1_

$a Moore, Lee E $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Choueiri, Toni K $u Dana-Farber Cancer Institute, Bostan, MA, USA.

700    1_

$a Wood, Christopher $u Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

700    1_

$a Johansson, Mattias $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a McKay, James D $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Brown, Kevin M $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Rothman, Nathaniel $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Lathrop, Mark G $u McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.

700    1_

$a Deleuze, Jean-Francois $u Centre National de Recherche en Génomique Humaine, , Institut de biologie François Jacob, CEA, Evry, France. Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.

700    1_

$a Wu, Xifeng $u Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

700    1_

$a Brennan, Paul $u International Agency for Research on Cancer (IARC), Lyon, France.

700    1_

$a Chanock, Stephen J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Purdue, Mark P $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MD, USA.

700    1_

$a Scelo, Ghislaine $u International Agency for Research on Cancer (IARC), Lyon, France. scelog@iarc.fr.

773    0_

$w MED00005019 $t European journal of human genetics : EJHG $x 1476-5438 $g Roč. 27, č. 10 (2019), s. 1589-1598

856    41

$u https://pubmed.ncbi.nlm.nih.gov/31231134 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y a $z 0

990    __

$a 20201125 $b ABA008

991    __

$a 20201214130610 $b ABA008

999    __

$a ok $b bmc $g 1595939 $s 1114296

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2019 $b 27 $c 10 $d 1589-1598 $e 20190623 $i 1476-5438 $m European journal of human genetics $n Eur J Hum Genet $x MED00005019

GRA    __

$a 10124 $p Cancer Research UK $2 United Kingdom

GRA    __

$a R01 CA170298 $p NCI NIH HHS $2 United States

GRA    __

$a U01 CA155309 $p NCI NIH HHS $2 United States

LZP    __

$a Pubmed-20201125