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Autor
Abedi-Ardekani, Behnoush 1 Albanes, Demetrius 1 Anderson, Garnet L 1 Andreotti, Gabriella 1 Anema, John G 1 Bacq-Daian, Delphine 1 Banks, Rosamonde E 1 Beane Freeman, Laura E 1 Bencko, Vladimir 1 Benhamou, Simone 1 Black, Amanda 1 Blanche, Helene 1 Boland, Anne 1 Brennan, Paul 1 Brown, Kevin M 1 Bruinsma, Fiona 1 Burdett, Laurie 1 Cancel-Tassin, Geraldine 1 Carol, Hallie 1 Chanock, Stephen J 1
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Pracoviště
1st Faculty of Medicine Institute of ... 1 2nd Faculty of Medicine Institute of ... 1 Brigham and Women's Hospital and VA B... 1 Brown University Providence RI USA 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Prevention Program Fred Hutchi... 1 Carol Davila University of Medicine a... 1 Center 'Bioengineering' of the Russia... 1 Centre National de Recherche en Génom... 1 Centre National de Recherche en Génom... 1 Dana Farber Cancer Institute Bostan M... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Epidemiology Division o... 1 Department of Epidemiology Nofer Inst... 1 Department of Epidemiology and Biosta... 1 Department of Oncology University of ... 1 Department of Preventive Medicine Fac... 1
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Autor
Abedi-Ardekani, Behnoush 1 Albanes, Demetrius 1 Anderson, Garnet L 1 Andreotti, Gabriella 1 Anema, John G 1 Bacq-Daian, Delphine 1 Banks, Rosamonde E 1 Beane Freeman, Laura E 1 Bencko, Vladimir 1 Benhamou, Simone 1 Black, Amanda 1 Blanche, Helene 1 Boland, Anne 1 Brennan, Paul 1 Brown, Kevin M 1 Bruinsma, Fiona 1 Burdett, Laurie 1 Cancel-Tassin, Geraldine 1 Carol, Hallie 1 Chanock, Stephen J 1
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Pracoviště
1st Faculty of Medicine Institute of ... 1 2nd Faculty of Medicine Institute of ... 1 Brigham and Women's Hospital and VA B... 1 Brown University Providence RI USA 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Prevention Program Fred Hutchi... 1 Carol Davila University of Medicine a... 1 Center 'Bioengineering' of the Russia... 1 Centre National de Recherche en Génom... 1 Centre National de Recherche en Génom... 1 Dana Farber Cancer Institute Bostan M... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Epidemiology Division o... 1 Department of Epidemiology Nofer Inst... 1 Department of Epidemiology and Biosta... 1 Department of Oncology University of ... 1 Department of Preventive Medicine Fac... 1
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NLK
Free Medical Journals
od 2009
PubMed Central
od 2009 do Před 1 rokem
Europe PubMed Central
od 2009 do Před 1 rokem
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1998-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
31231134
DOI
10.1038/s41431-019-0455-9
Knihovny.cz E-zdroje
Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 controls) and women (1399 cases, 1575 controls) from two independent cohorts of European origin. Our study confirmed sex-specific associations for two known RCC risk loci at 14q24.2 (DPF3) and 2p21(EPAS1). We also identified two additional suggestive male-specific loci at 6q24.3 (SAMD5, male odds ratio (ORmale) = 0.83 [95% CI = 0.78-0.89], Pmale = 1.71 × 10-8 compared with female odds ratio (ORfemale) = 0.98 [95% CI = 0.90-1.07], Pfemale = 0.68) and 12q23.3 (intergenic, ORmale = 0.75 [95% CI = 0.68-0.83], Pmale = 1.59 × 10-8 compared with ORfemale = 0.93 [95% CI = 0.82-1.06], Pfemale = 0.21) that attained genome-wide significance in the joint meta-analysis. Herein, we provide evidence of sex-specific associations in RCC genetic susceptibility and advocate the necessity of larger genetic and genomic studies to unravel the endogenous causes of sex bias in sexually dimorphic traits and diseases like RCC.
- MeSH
- celogenomová asociační studie * MeSH
- genetická predispozice k nemoci * MeSH
- jednonukleotidový polymorfismus MeSH
- karcinom z renálních buněk epidemiologie genetika MeSH
- lidé MeSH
- lokus kvantitativního znaku MeSH
- nádory ledvin epidemiologie genetika MeSH
- odds ratio MeSH
- sexuální faktory MeSH
- výpočetní biologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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