• Je něco špatně v tomto záznamu ?

Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort

SS. Bellur, ISD. Roberts, S. Troyanov, V. Royal, R. Coppo, HT. Cook, D. Cattran, Y. Arce Terroba, AM. Asunis, I. Bajema, E. Bertoni, JA. Bruijn, P. Cannata-Ortiz, D. Casartelli, A. Maria Di Palma, F. Ferrario, M. Fortunato, L. Furci, H....

. 2019 ; 34 (10) : 1681-1690. [pub] 20191001

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem, validační studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023653

BACKGROUND: The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS. RESULTS: All glomerular lesions (M, E, C and S) assessed by local pathologists were independently associated with the decision to administer CS/IS therapy, while the severity of tubulointerstitial lesions was not. Reproducibility between local and central pathologists was moderate for S (segmental sclerosis) and T (tubular atrophy/interstitial fibrosis), and poor for M (mesangial hypercellularity), E (endocapillary hypercellularity) and C (crescents). Local pathologists found statistically more of each lesion, except for the S lesion, which was more frequent with central review. Disagreements were more likely to occur when the proportion of glomeruli affected was low. The M lesion, assessed by central pathologists, correlated better with the severity of the disease at presentation and discriminated better with outcomes. In contrast, the E lesion, evaluated by local pathologists, correlated better with the clinical presentation and outcomes when compared with central review. Both C and S lesions, when discordant between local and central pathologists, had a clinical phenotype intermediate to double absent lesions (milder disease) and double present (more severe). CONCLUSION: We conclude that differences in the scoring of MEST-C criteria between local pathologists and a central reviewer have a significant impact on the prognostic value of the Oxford Classification. Since the decision to offer immunosuppressive therapy in this cohort was intimately associated with the MEST-C score, this study indicates a need for a more detailed guidance for pathologists in the scoring of IgAN biopsies.

Alessandro Manzoni Hospital Lecco Italy

Careggi University Hospital Florence Italy

City of the Health and the Science of Turin Health Agency Regina Margherita Children's Hospital Turin Italy

German Cancer Research Center INF 280 Heidelberg Germany

Hacettepe University Institute of Children's Health Ankara Turkey

Hippokration General Hospital Aristotle University of Thessaloniki Thessaloniki Greece

Hôpital du Sacré Coeur de Montréal Montreal Canada

Hôpital Maisonneuve Rosemont Montreal Canada

Hospital Universitari de Bellvitge Barcelona Spain

Imperial College Hammersmith Hospital London UK

ISS Fundación Jiménez Díaz Madrid Spain

Istanbul University Istanbul Turkey

Karolinska Institute Stockholm Sweden

Leiden University Medical Center Leiden The Netherlands

Medical University of Silesia Katowice Poland

Medical University of Warsaw Warsaw Poland

National and Kapodistrian University of Athens Greece Athens Greece

Nephrology Department University Hospital October 12 Madrid Spain

Nephrology Fundacion Puigvert Barcelona Spain

Nephrology Medical School University of Ioannina Ioannina Greece

Nephropathology Radboud University Nijmegen Medical Center Nijmegen The Netherlands

Nephropathology San Gerardo Hospital Monza Italy

Oxford University Hospitals Oxford UK

Pathology Drug Safety and Metabolism IMED Biotech Unit AstraZeneca Gothenburg Sweden

Pathology G Brotzu Hospital Cagliari Italy

Pathology Institute for Clinical and Experimental Medicine Prague Czech Republic

Pathology Leicester General Hospital Leicester UK

Pathology Policlinic of Modena and Reggio Emilia Modena Italy

Pathology S Andrea Hospital Rome Italy

Pathology S Croce Hospital Cuneo Italy

Pathology Tartu University Clinics Tartu Estonia

Pathology University of Turin Italy

Pathology Western Infirmary Glasgow Glasgow UK

Sapienza University of Rome Rome Italy

School of Medicine University Hospital Dubrava University of Zagreb Zagreb Croatia

Spedali Civili di Brescia Brescia Italy

Toronto General Hospital University Health Network Toronto Ontario Canada

Transplantation Medicine and Nephrology Warsaw Medical University Warsaw Poland

University of Bari Bari Italy

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023653
003      
CZ-PrNML
005      
20201214130729.0
007      
ta
008      
201125s2019 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/ndt/gfy337 $2 doi
035    __
$a (PubMed)30561721
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Bellur, Shubha S $u Oxford University Hospitals, Oxford, UK.
245    10
$a Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort / $c SS. Bellur, ISD. Roberts, S. Troyanov, V. Royal, R. Coppo, HT. Cook, D. Cattran, Y. Arce Terroba, AM. Asunis, I. Bajema, E. Bertoni, JA. Bruijn, P. Cannata-Ortiz, D. Casartelli, A. Maria Di Palma, F. Ferrario, M. Fortunato, L. Furci, H. Gakiopoulou, D. Galesic Ljubanovic, K. Giannakakis, M. Gomà, HJ. Gröne, E. Gutiérrez, S. Asma Haider, E. Honsova, E. Ioachim, H. Karkoszka, D. Kipgen, J. Maldyk, G. Mazzucco, D. Orhan, Y. Ozluk, A. Pantzaki, A. Perkowska-Ptasinska, Z. Riispere, MP. Soderberg, E. Steenbergen, A. Stoppacciaro, B. Sundelin Von Feilitzen, R. Tardanico,
520    9_
$a BACKGROUND: The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists followed by central review in Oxford. We had two distinct objectives: to assess how closely pathology findings were associated with the decision to give corticosteroid/immunosuppressive (CS/IS) treatments, and to determine the impact of differences in MEST-C scoring between central and local pathologists on the clinical value of the Oxford Classification. We tested for each lesion the associations between the type of agreement (local and central pathologists scoring absent, local present and central absent, local absent and central present, both scoring present) with the initial clinical assessment, as well as long-term outcomes in those patients who did not receive CS/IS. RESULTS: All glomerular lesions (M, E, C and S) assessed by local pathologists were independently associated with the decision to administer CS/IS therapy, while the severity of tubulointerstitial lesions was not. Reproducibility between local and central pathologists was moderate for S (segmental sclerosis) and T (tubular atrophy/interstitial fibrosis), and poor for M (mesangial hypercellularity), E (endocapillary hypercellularity) and C (crescents). Local pathologists found statistically more of each lesion, except for the S lesion, which was more frequent with central review. Disagreements were more likely to occur when the proportion of glomeruli affected was low. The M lesion, assessed by central pathologists, correlated better with the severity of the disease at presentation and discriminated better with outcomes. In contrast, the E lesion, evaluated by local pathologists, correlated better with the clinical presentation and outcomes when compared with central review. Both C and S lesions, when discordant between local and central pathologists, had a clinical phenotype intermediate to double absent lesions (milder disease) and double present (more severe). CONCLUSION: We conclude that differences in the scoring of MEST-C criteria between local pathologists and a central reviewer have a significant impact on the prognostic value of the Oxford Classification. Since the decision to offer immunosuppressive therapy in this cohort was intimately associated with the MEST-C score, this study indicates a need for a more detailed guidance for pathologists in the scoring of IgAN biopsies.
650    _2
$a biopsie $7 D001706
650    _2
$a hodnoty glomerulární filtrace $7 D005919
650    _2
$a IgA nefropatie $x klasifikace $x farmakoterapie $x patologie $7 D005922
650    _2
$a lidé $7 D006801
650    _2
$a imunosupresiva $x terapeutické užití $7 D007166
650    12
$a statistické modely $7 D015233
650    12
$a odchylka pozorovatele $7 D015588
650    12
$a výběr pacientů $7 D018579
650    _2
$a prognóza $7 D011379
650    _2
$a reprodukovatelnost výsledků $7 D015203
650    _2
$a retrospektivní studie $7 D012189
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a validační studie $7 D023361
700    1_
$a Roberts, Ian S D $u Oxford University Hospitals, Oxford, UK.
700    1_
$a Troyanov, Stéphan $u Hôpital du Sacré-Coeur de Montréal, Montreal, Canada.
700    1_
$a Royal, Virginie $u Hôpital Maisonneuve-Rosemont, Montreal, Canada.
700    1_
$a Coppo, Rosanna $u City of the Health and the Science of Turin Health Agency, Regina Margherita Children's Hospital, Turin, Italy.
700    1_
$a Cook, H Terence $u Imperial College, Hammersmith Hospital, London, UK.
700    1_
$a Cattran, Daniel $u Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
700    1_
$a Arce Terroba, Yolanda $u Nephrology, Fundacion Puigvert, Barcelona, Spain.
700    1_
$a Asunis, Anna Maria $u Pathology, G. Brotzu Hospital, Cagliari, Italy.
700    1_
$a Bajema, Ingeborg $u Leiden University Medical Center, Leiden, The Netherlands.
700    1_
$a Bertoni, Elisabetta $u Careggi-University Hospital, Florence, Italy.
700    1_
$a Bruijn, Jan A $u Leiden University Medical Center, Leiden, The Netherlands.
700    1_
$a Cannata-Ortiz, Pablo $u ISS-Fundación Jiménez Díaz, Madrid, Spain.
700    1_
$a Casartelli, Donatella $u Alessandro Manzoni Hospital, Lecco, Italy.
700    1_
$a Maria Di Palma, Anna $u University of Bari, Bari, Italy.
700    1_
$a Ferrario, Franco $u Nephropathology, San Gerardo Hospital, Monza, Italy.
700    1_
$a Fortunato, Mirella $u Pathology, S. Croce Hospital, Cuneo, Italy.
700    1_
$a Furci, Luciana $u Pathology, Policlinic of Modena and Reggio Emilia, Modena, Italy.
700    1_
$a Gakiopoulou, Hariklia $u National and Kapodistrian University of Athens, Greece, Athens, Greece.
700    1_
$a Galesic Ljubanovic, Danica $u School of Medicine, University Hospital Dubrava, University of Zagreb, Zagreb, Croatia.
700    1_
$a Giannakakis, Konstantinos $u Sapienza University of Rome, Rome, Italy.
700    1_
$a Gomà, Montserrat $u Hospital Universitari de Bellvitge, Barcelona, Spain.
700    1_
$a Gröne, Hermann-Josef $u German Cancer Research Center, INF 280, Heidelberg, Germany.
700    1_
$a Gutiérrez, Eduardo $u Nephrology Department, University Hospital October 12, Madrid, Spain.
700    1_
$a Asma Haider, S $u Pathology, Leicester General Hospital, Leicester, UK.
700    1_
$a Honsova, Eva $u Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Ioachim, Elli $u Nephrology, Medical School University of Ioannina, Ioannina, Greece.
700    1_
$a Karkoszka, Henryk $u Medical University of Silesia, Katowice, Poland.
700    1_
$a Kipgen, David $u Pathology, Western Infirmary Glasgow, Glasgow, UK.
700    1_
$a Maldyk, Jagoda $u Medical University of Warsaw, Warsaw, Poland.
700    1_
$a Mazzucco, Gianna $u Pathology, University of Turin, Italy.
700    1_
$a Orhan, Diclehan $u Hacettepe University Institute of Children's Health, Ankara, Turkey.
700    1_
$a Ozluk, Yasemin $u Istanbul University, Istanbul, Turkey.
700    1_
$a Pantzaki, Afroditi $u Hippokration General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
700    1_
$a Perkowska-Ptasinska, Agnieszka $u Transplantation Medicine and Nephrology, Warsaw Medical University, Warsaw, Poland.
700    1_
$a Riispere, Zivili $u Pathology, Tartu University Clinics, Tartu, Estonia.
700    1_
$a Soderberg, Magnus P $u Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.
700    1_
$a Steenbergen, Eric $u Nephropathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
700    1_
$a Stoppacciaro, Antonella $u Pathology S. Andrea Hospital, Rome, Italy.
700    1_
$a Sundelin Von Feilitzen, Birgitta $u Karolinska Institute, Stockholm, Sweden.
700    1_
$a Tardanico, Regina $u Spedali Civili di Brescia, Brescia, Italy.
773    0_
$w MED00010288 $t Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association $x 1460-2385 $g Roč. 34, č. 10 (2019), s. 1681-1690
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30561721 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214130727 $b ABA008
999    __
$a ok $b bmc $g 1595972 $s 1114329
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 34 $c 10 $d 1681-1690 $e 20191001 $i 1460-2385 $m Nephrology, dialysis, transplantation $n Nephrol Dial Transplant $x MED00010288
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace