• Je něco špatně v tomto záznamu ?

Association between aortic telomere length and cardiac post-transplant allograft function

D. Dlouha, J. Vymetalova, JA. Hubacek, V. Lanska, I. Malek,

. 2019 ; 290 (-) : 129-133. [pub] 20190507

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023699

BACKGROUND: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. MATERIALS AND METHODS: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 ± 11.8 years) and 383 donors (age 38.6 ± 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. RESULTS: Shorter telomere length was detected in heart allograft recipients compared to donors (P < 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P < 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P < 0.03), as well as in subjects with cardiac allograft vasculopathy (P < 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P < 0.004). CONCLUSIONS: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023699
003      
CZ-PrNML
005      
20201214130855.0
007      
ta
008      
201125s2019 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijcard.2019.05.006 $2 doi
035    __
$a (PubMed)31101542
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Dlouha, Dana $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic. Electronic address: dadl@ikem.cz.
245    10
$a Association between aortic telomere length and cardiac post-transplant allograft function / $c D. Dlouha, J. Vymetalova, JA. Hubacek, V. Lanska, I. Malek,
520    9_
$a BACKGROUND: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. MATERIALS AND METHODS: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 ± 11.8 years) and 383 donors (age 38.6 ± 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. RESULTS: Shorter telomere length was detected in heart allograft recipients compared to donors (P < 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P < 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P < 0.03), as well as in subjects with cardiac allograft vasculopathy (P < 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P < 0.004). CONCLUSIONS: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results.
650    _2
$a dospělí $7 D000328
650    _2
$a aorta $x fyziologie $7 D001011
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a rejekce štěpu $x diagnóza $x genetika $x patofyziologie $7 D006084
650    _2
$a transplantace srdce $x trendy $7 D016027
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a telomery $x fyziologie $7 D016615
650    _2
$a zkracování telomer $x fyziologie $7 D059506
650    _2
$a dárci tkání $7 D014019
650    _2
$a homologní transplantace $x trendy $7 D014184
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vymetalova, Jevgenija $u Cardio Centre, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic.
700    1_
$a Hubacek, Jaroslav A $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic.
700    1_
$a Lanska, Vera $u Statistical Unit, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic.
700    1_
$a Malek, Ivan $u Cardio Centre, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 14021, Czech Republic.
773    0_
$w MED00002299 $t International journal of cardiology $x 1874-1754 $g Roč. 290, č. - (2019), s. 129-133
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31101542 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214130854 $b ABA008
999    __
$a ok $b bmc $g 1596018 $s 1114375
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 290 $c - $d 129-133 $e 20190507 $i 1874-1754 $m International journal of cardiology $n Int J Cardiol $x MED00002299
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace