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Lifespan normative data on rates of brain volume changes
M. Battaglini, G. Gentile, L. Luchetti, A. Giorgio, H. Vrenken, F. Barkhof, KS. Cover, R. Bakshi, R. Chu, MP. Sormani, C. Enzinger, S. Ropele, O. Ciccarelli, C. Wheeler-Kingshott, M. Yiannakas, M. Filippi, MA. Rocca, P. Preziosa, A. Gallo, A....
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Atrophy MeSH
- Diffusion Magnetic Resonance Imaging MeSH
- Longevity * MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain diagnostic imaging pathology MeSH
- Multicenter Studies as Topic MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging pathology MeSH
- Organ Size MeSH
- Imaging, Three-Dimensional MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
Brain MRI 3T UK Research Center C Mondino National Neurological Institute Pavia Italy
CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing China
Department of Brain and Behavioural Sciences University of Pavia Pavia Italy
Department of Health Sciences University of Genoa Genoa Italy
Department of Medicine Surgery and Neuroscience University of Siena Siena Italy
Department of Neurology Medical University of Graz Graz Austria
Department of Neurosciences S Camillo Forlanini Hospital Rome Italy
Department of Physics and Medical Technology VU University Medical Center Amsterdam the Netherlands
Department of Psychology University of Chinese Academy of Sciences Beijing China
Department of Radiology and Nuclear Medicine MS Center Amsterdam Amsterdam the Netherlands
Institutes of Neurology and Healthcare Engineering UCL London UK
National Institute for Health Research London UK
Queen Square Multiple Sclerosis Centre UCL Institute of Neurology University College London UK
References provided by Crossref.org
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- $a We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
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