-
Je něco špatně v tomto záznamu ?
Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study
R. Adam, V. Karam, V. Cailliez, P. Trunečka, D. Samuel, G. Tisone, P. Němec, O. Soubrane, S. Schneeberger, B. Gridelli, WO. Bechstein, A. Risaliti, PD. Line, M. Vivarelli, M. Rossi, J. Pirenne, JL. Klempnauer, A. Rummo, F. Di Benedetto, K....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie, práce podpořená grantem
- MeSH
- časové faktory MeSH
- hodnocení rizik MeSH
- imunosupresiva aplikace a dávkování škodlivé účinky MeSH
- inhibitory kalcineurinu aplikace a dávkování škodlivé účinky MeSH
- léky s prodlouženým účinkem MeSH
- lidé středního věku MeSH
- lidé MeSH
- přežívání štěpu účinky léků MeSH
- příprava léků MeSH
- registrace MeSH
- rejekce štěpu imunologie mortalita prevence a kontrola MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- senioři MeSH
- takrolimus aplikace a dávkování škodlivé účinky MeSH
- transplantace jater * škodlivé účinky mortalita MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Geografické názvy
- Evropa MeSH
BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study. METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004). RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T. CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.
Abdominal Transplant Surgery University Hospital Leuven Leuven Belgium
Center of Cardiovascular Surgery and Transplantation Brno Czech Republic
Department for Surgery and Transplantation University Hospital Copenhagen Copenhagen Denmark
Department of Digestive Surgery AP HP Beaujon Hospital Clichy France
Department of Digestive Surgery Archet 2 Hospital Nice France
Department of General and Transplant Surgery University Hospital Essen Essen Germany
Department of General and Visceral Surgery Goethe University Hospital and Clinics Frankfurt Germany
Department of General Surgery and Transplantation Hospital G Brotzu Cagliari Italy
Department of General Transplant and Liver Surgery Medical University of Warsaw Warsaw Poland
Department of General Visceral and Transplantation Surgery Hannover Medical School Hannover Germany
Department of Hepatology and Gastroenterology University Hospital of Henri Mondor Creteil France
Department of Surgery Hospital Hautepierre University Hospitals of Strasbourg Strasbourg France
Department of Surgery Liver Transplant Unit University Hospital Udine Udine Italy
Department of Surgery Pope John XXIII Hospital Bergamo Italy
Department of Transplantation Medicine Oslo University Hospital Oslo Norway
Department of Transplantation Surgery Karolinska University Hospital Huddinge Sweden
Department of Visceral and Transplant Surgery University Hospital Zurich Zurich Switzerland
Department of Visceral Surgery University Hospital Rennes Pontchaillou Hospital Rennes France
Liver Transplant Unit Tor Vergata Polyclinic University of Rome Tor Vergata Rome Italy
Liver Transplantation Unit University of Edinburgh Royal Infirmary Edinburgh United Kingdom
Liver Unit King's College Hospital London United Kingdom
Liver Unit St Vincent's Hospital Dublin Ireland
Mediterranean Institute for Transplantation and Advanced Specialized Therapies Palermo Sicily Italy
Republican Scientific and Practical Center for Organ and Tissue Transplantation Minsk Belarus
St James and Seacroft University Hospital Leeds United Kingdom
Surgery and Organ Transplantation Center Central Hospital of Oil Workers Baku Azerbaijan
Surgery Clinic Tartu University Hospital Tartu Estonia
Surgical Clinic and Polyclinic University Hospital Klinikum rechts der Isar Munich Munich Germany
Transplant Center Institute for Clinical and Experimental Medicine Prague Czech Republic
University of Bologna Transplant and HPB Institute Bologna Italy
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20023726
- 003
- CZ-PrNML
- 005
- 20201214130950.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/TP.0000000000002700 $2 doi
- 035 __
- $a (PubMed)31343568
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Adam, René $u Hepato-Biliary Center, AP-HP Paul Brousse Hospital, University of Paris-Sud, INSERM U935, Villejuif, France.
- 245 10
- $a Improved Survival in Liver Transplant Patients Receiving Prolonged-release Tacrolimus-based Immunosuppression in the European Liver Transplant Registry (ELTR): An Extension Study / $c R. Adam, V. Karam, V. Cailliez, P. Trunečka, D. Samuel, G. Tisone, P. Němec, O. Soubrane, S. Schneeberger, B. Gridelli, WO. Bechstein, A. Risaliti, PD. Line, M. Vivarelli, M. Rossi, J. Pirenne, JL. Klempnauer, A. Rummo, F. Di Benedetto, K. Zieniewicz, R. Troisi, A. Paul, T. Vali, O. Kollmar, K. Boudjema, E. Hoti, M. Colledan, J. Pratschke, H. Lang, I. Popescu, BG. Ericzon, K. Strupas, P. De Simone, E. Kochs, B. Heyd, J. Gugenheim, AD. Pinna, W. Bennet, M. Kazimi, P. Bachellier, SJ. Wigmore, A. Rasmussen, PA. Clavien, E. Hidalgo, JG. O'Grady, F. Zamboni, M. Kilic, C. Duvoux, all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA),
- 520 9_
- $a BACKGROUND: We compared, through the European Liver Transplant Registry, long-term liver transplantation outcomes with prolonged-release tacrolimus (PR-T) versus immediate-release tacrolimus (IR-T)-based immunosuppression. This retrospective analysis comprises up to 8-year data collected between 2008 and 2016, in an extension of our previously published study. METHODS: Patients with <1 month follow-up were excluded; patients were propensity score matched for baseline characteristics. Efficacy measures included: univariate/multivariate analyses of risk factors influencing graft/patient survival up to 8 years posttransplantation, and graft/patient survival up to 4 years with PR-T versus IR-T. Overall, 13 088 patients were included from 44 European centers; propensity score-matched analyses comprised 3006 patients (PR-T: n = 1002; IR-T: n = 2004). RESULTS: In multivariate analyses, IR-T-based immunosuppression was associated with reduced graft survival (risk ratio, 1.49; P = 0.0038) and patient survival (risk ratio, 1.40; P = 0.0215). There was improvement with PR-T versus IR-T in graft survival (83% versus 77% at 4 y, respectively; P = 0.005) and patient survival (85% versus 80%; P = 0.017). Patients converted from IR-T to PR-T after 1 month had a higher graft survival rate than patients receiving IR-T at last follow-up (P < 0.001), or started and maintained on PR-T (P = 0.019). One graft loss in 4 years was avoided for every 14.3 patients treated with PR-T versus IR-T. CONCLUSIONS: PR-T-based immunosuppression might improve long-term outcomes in liver transplant recipients than IR-T-based immunosuppression.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a inhibitory kalcineurinu $x aplikace a dávkování $x škodlivé účinky $7 D065095
- 650 _2
- $a léky s prodlouženým účinkem $7 D003692
- 650 _2
- $a příprava léků $7 D004339
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a rejekce štěpu $x imunologie $x mortalita $x prevence a kontrola $7 D006084
- 650 _2
- $a přežívání štěpu $x účinky léků $7 D006085
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunosupresiva $x aplikace a dávkování $x škodlivé účinky $7 D007166
- 650 12
- $a transplantace jater $x škodlivé účinky $x mortalita $7 D016031
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a registrace $7 D012042
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a hodnocení rizik $7 D018570
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a takrolimus $x aplikace a dávkování $x škodlivé účinky $7 D016559
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a výsledek terapie $7 D016896
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Karam, Vincent $u Hepato-Biliary Center, AP-HP Paul Brousse Hospital, University of Paris-Sud, INSERM U935, Villejuif, France.
- 700 1_
- $a Cailliez, Valérie $u Hepato-Biliary Center, AP-HP Paul Brousse Hospital, University of Paris-Sud, INSERM U935, Villejuif, France.
- 700 1_
- $a Trunečka, Pavel $u Transplant Center, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
- 700 1_
- $a Samuel, Didier $u Hepato-Biliary Center, AP-HP Paul Brousse Hospital, University of Paris-Sud, INSERM U935, Villejuif, France.
- 700 1_
- $a Tisone, Giuseppe $u Liver Transplant Unit, Tor Vergata Polyclinic, University of Rome Tor Vergata, Rome, Italy.
- 700 1_
- $a Němec, Petr $u Center of Cardiovascular Surgery and Transplantation, Brno, Czech Republic.
- 700 1_
- $a Soubrane, Olivier $u Department of Digestive Surgery, AP-HP Beaujon Hospital, Clichy, France.
- 700 1_
- $a Schneeberger, Stefan $u Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
- 700 1_
- $a Gridelli, Bruno $u Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, Sicily, Italy.
- 700 1_
- $a Bechstein, Wolf O $u Department of General and Visceral Surgery, Goethe University Hospital and Clinics, Frankfurt, Germany.
- 700 1_
- $a Risaliti, Andrea $u Department of Surgery, Liver Transplant Unit, University Hospital Udine, Udine, Italy.
- 700 1_
- $a Line, Pal-Dag $u Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
- 700 1_
- $a Vivarelli, Marco $u Hepatobiliary and Abdominal Transplantation Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.
- 700 1_
- $a Rossi, Massimo $u Department of General Surgery, Organ Transplant Unit "Paride Stefanini", Umberto 1 Policlinico of Rome, Rome, Italy.
- 700 1_
- $a Pirenne, Jacques $u Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium.
- 700 1_
- $a Klempnauer, Jurgen L $u Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Rummo, Aleh $u Republican Scientific and Practical Center (RSPC) for Organ and Tissue Transplantation, Minsk, Belarus.
- 700 1_
- $a Di Benedetto, Fabrizio $u Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
- 700 1_
- $a Zieniewicz, Krzysztof $u Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
- 700 1_
- $a Troisi, Roberto $u Department of General Hepato-Biliary and Liver Transplantation Surgery, Ghent University Hospital Medical School, Belgium.
- 700 1_
- $a Paul, Andreas $u Department of General and Transplant Surgery, University Hospital Essen, Essen, Germany.
- 700 1_
- $a Vali, Toomas $u Surgery Clinic, Tartu University Hospital, Tartu, Estonia.
- 700 1_
- $a Kollmar, Otto $u Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.
- 700 1_
- $a Boudjema, Karim $u Department of Visceral Surgery, University Hospital Rennes, Pontchaillou Hospital, Rennes, France.
- 700 1_
- $a Hoti, Emir $u Liver Unit, St. Vincent's Hospital, Dublin, Ireland.
- 700 1_
- $a Colledan, Michele $u Department of Surgery, Pope John XXIII Hospital, Bergamo, Italy.
- 700 1_
- $a Pratschke, Johan $u Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow-Klinikum (CVK), Berlin, Germany.
- 700 1_
- $a Lang, Hauke $u General, Visceral and Transplantation Surgery Clinic, Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Popescu, Irinel $u Department of Surgery and Liver Transplantation, Fundeni Clinical Institute, University of Medicine "Carol Davila", Bucharest, Romania.
- 700 1_
- $a Ericzon, Bo-Goran $u Department of Transplantation Surgery, Karolinska University Hospital, Huddinge, Sweden.
- 700 1_
- $a Strupas, Kestutis $u Department for Gastroentrology, Nephrology and Surgery, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
- 700 1_
- $a De Simone, Paolo $u Hepatobiliary Surgery and Liver Transplantation Unit, University of Pisa Medical School Hospital, Pisa, Italy.
- 700 1_
- $a Kochs, Eberhard $u Surgical Clinic and Polyclinic, University Hospital Klinikum rechts der Isar Munich, Munich, Germany.
- 700 1_
- $a Heyd, Bruno $u Department of Visceral Surgery, University Hospital Besançon, University of Franche-Comté, Besançon, France.
- 700 1_
- $a Gugenheim, Jean $u Department of Digestive Surgery, Archet 2 Hospital, Nice, France.
- 700 1_
- $a Pinna, Antonio D $u University of Bologna, Transplant and HPB Institute, Bologna, Italy.
- 700 1_
- $a Bennet, William $u Surgery Department, Transplantation and Liver Surgery Unit, Sahlgrenska University Hospital, Gothenburg, Sweden.
- 700 1_
- $a Kazimi, Mirjalal $u Surgery and Organ Transplantation Center, Central Hospital of Oil Workers, Baku, Azerbaijan.
- 700 1_
- $a Bachellier, Philippe $u Department of Surgery, Hospital Hautepierre, University Hospitals of Strasbourg, Strasbourg, France.
- 700 1_
- $a Wigmore, Stephen J $u Liver Transplantation Unit, University of Edinburgh Royal Infirmary, Edinburgh, United Kingdom.
- 700 1_
- $a Rasmussen, Allan $u Department for Surgery and Transplantation, University Hospital Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Clavien, Pierre-Alain $u Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.
- 700 1_
- $a Hidalgo, Ernest $u St James and Seacroft University Hospital, Leeds, United Kingdom.
- 700 1_
- $a O'Grady, John G $u Liver Unit, King's College Hospital, London, United Kingdom.
- 700 1_
- $a Zamboni, Frausto $u Department of General Surgery and Transplantation, Hospital G. Brotzu, Cagliari, Italy.
- 700 1_
- $a Kilic, Murat $u Kent Hospital, Izmir, Turkey.
- 700 1_
- $a Duvoux, Christophe $u Department of Hepatology and Gastroenterology, University Hospital of Henri-Mondor, Creteil, France.
- 710 2_
- $a all contributing centers (www.eltr.org) and the European Liver and Intestine Transplant Association (ELITA)
- 773 0_
- $w MED00010695 $t Transplantation $x 1534-6080 $g Roč. 103, č. 9 (2019), s. 1844-1862
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31343568 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201214130947 $b ABA008
- 999 __
- $a ok $b bmc $g 1596045 $s 1114402
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 103 $c 9 $d 1844-1862 $e - $i 1534-6080 $m Transplantation $n Transplantation $x MED00010695
- LZP __
- $a Pubmed-20201125
