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The role of intestinal microbiota in the pathogenesis of colorectal carcinoma
J. Kuzma, D. Chmelař, M. Hájek, A. Lochmanová, I. Čižnár, M. Rozložník, M. Klugar,
Language English Country United States
Document type Journal Article, Review
- MeSH
- Cytokines immunology MeSH
- Diet MeSH
- Dysbiosis * MeSH
- Gastrointestinal Tract microbiology physiopathology MeSH
- Colorectal Neoplasms microbiology pathology MeSH
- Humans MeSH
- Reactive Oxygen Species metabolism MeSH
- Gastrointestinal Microbiome * MeSH
- Symbiosis MeSH
- Inflammation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Chronic low-grade inflammation is associated with the development of CRC, through the production of inflammatory cytokines and reactive oxygen species. CRC occurs in association with high-protein and high-fat diets in combination with low-fiber intake. The problem of intestinal dysbiosis and oncological diseases is a multidisciplinary problem and it is necessary to focus on several fields of medicine such as public health, clinical pharmacology, and internal medicine. The aim of this review is describing the role of gut dysbiosis in pathogenesis of colorectal carcinoma.
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- $a Kuzma, Jozef $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic.
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- $a The role of intestinal microbiota in the pathogenesis of colorectal carcinoma / $c J. Kuzma, D. Chmelař, M. Hájek, A. Lochmanová, I. Čižnár, M. Rozložník, M. Klugar,
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- $a The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Chronic low-grade inflammation is associated with the development of CRC, through the production of inflammatory cytokines and reactive oxygen species. CRC occurs in association with high-protein and high-fat diets in combination with low-fiber intake. The problem of intestinal dysbiosis and oncological diseases is a multidisciplinary problem and it is necessary to focus on several fields of medicine such as public health, clinical pharmacology, and internal medicine. The aim of this review is describing the role of gut dysbiosis in pathogenesis of colorectal carcinoma.
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- $a Chmelař, Dittmar $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Czech Anaerobic Bacteria Reference Laboratory, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
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- $a Hájek, Michal $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. michalhajek@email.cz. Centre of Hyperbaric Medicine, Ostrava City Hospital, Ostrava, Czech Republic. michalhajek@email.cz.
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- $a Lochmanová, Alexandra $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Department of Immunology and Alergology, Public Health Institute Ostrava, Ostrava, Czech Republic.
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- $a Čižnár, Ivan $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia.
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- $a Rozložník, Miroslav $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic.
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- $a Klugar, Miloslav $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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