• Je něco špatně v tomto záznamu ?

The role of intestinal microbiota in the pathogenesis of colorectal carcinoma

J. Kuzma, D. Chmelař, M. Hájek, A. Lochmanová, I. Čižnár, M. Rozložník, M. Klugar,

. 2020 ; 65 (1) : 17-24. [pub] 20190418

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20024250

The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Chronic low-grade inflammation is associated with the development of CRC, through the production of inflammatory cytokines and reactive oxygen species. CRC occurs in association with high-protein and high-fat diets in combination with low-fiber intake. The problem of intestinal dysbiosis and oncological diseases is a multidisciplinary problem and it is necessary to focus on several fields of medicine such as public health, clinical pharmacology, and internal medicine. The aim of this review is describing the role of gut dysbiosis in pathogenesis of colorectal carcinoma.

000      
00000naa a2200000 a 4500
001      
bmc20024250
003      
CZ-PrNML
005      
20201208102224.0
007      
ta
008      
201208s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s12223-019-00706-2 $2 doi
035    __
$a (PubMed)31001762
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kuzma, Jozef $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic.
245    14
$a The role of intestinal microbiota in the pathogenesis of colorectal carcinoma / $c J. Kuzma, D. Chmelař, M. Hájek, A. Lochmanová, I. Čižnár, M. Rozložník, M. Klugar,
520    9_
$a The symbiotic relationship between intestinal microbiota and the host is a major mechanism of prevention against the development of chronic and metabolic diseases. The intestinal microbiota provides several physiological functions of the organism from the creation of a natural functional barrier with a subsequent immunostimulatory activity up to affecting the energy metabolism of the host. Disruption of physiological intestinal microbiota is reported as one of the major etiological factors of initiation and progression of colorectal carcinoma (CRC). Chronic low-grade inflammation is associated with the development of CRC, through the production of inflammatory cytokines and reactive oxygen species. CRC occurs in association with high-protein and high-fat diets in combination with low-fiber intake. The problem of intestinal dysbiosis and oncological diseases is a multidisciplinary problem and it is necessary to focus on several fields of medicine such as public health, clinical pharmacology, and internal medicine. The aim of this review is describing the role of gut dysbiosis in pathogenesis of colorectal carcinoma.
650    _2
$a kolorektální nádory $x mikrobiologie $x patologie $7 D015179
650    _2
$a cytokiny $x imunologie $7 D016207
650    _2
$a dieta $7 D004032
650    12
$a dysbióza $7 D064806
650    12
$a střevní mikroflóra $7 D000069196
650    _2
$a gastrointestinální trakt $x mikrobiologie $x patofyziologie $7 D041981
650    _2
$a lidé $7 D006801
650    _2
$a zánět $7 D007249
650    _2
$a reaktivní formy kyslíku $x metabolismus $7 D017382
650    _2
$a symbióza $7 D013559
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Chmelař, Dittmar $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Czech Anaerobic Bacteria Reference Laboratory, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
700    1_
$a Hájek, Michal $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. michalhajek@email.cz. Centre of Hyperbaric Medicine, Ostrava City Hospital, Ostrava, Czech Republic. michalhajek@email.cz.
700    1_
$a Lochmanová, Alexandra $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Department of Immunology and Alergology, Public Health Institute Ostrava, Ostrava, Czech Republic.
700    1_
$a Čižnár, Ivan $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic. Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia.
700    1_
$a Rozložník, Miroslav $u Department of Biomedical Sciences, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00, Ostrava-Zábřeh, Ostrava, Czech Republic.
700    1_
$a Klugar, Miloslav $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
773    0_
$w MED00011005 $t Folia microbiologica $x 1874-9356 $g Roč. 65, č. 1 (2020), s. 17-24
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31001762 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20201208 $b ABA008
991    __
$a 20201208102220 $b ABA008
999    __
$a ok $b bmc $g 1593205 $s 1114931
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 65 $c 1 $d 17-24 $e 20190418 $i 1874-9356 $m Folia microbiologica $n Folia microbiol. (Prague) $x MED00011005
LZP    __
$a Pubmed-20201208

Najít záznam

Citační ukazatele

Možnosti archivace