• Something wrong with this record ?

Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen

ED. Avila-Calderón, L. Flores-Romo, W. Sharon, L. Donis-Maturano, MA. Becerril-García, MGA. Arreola, BA. Reynoso, FS. Güemes, A. Contreras-Rodríguez,

. 2020 ; 65 (1) : 1-16. [pub] 20190219

Language English Country United States

Document type Journal Article, Review

As dendritic cells (DCs) are among the first cells to encounter antigens, these cells trigger both innate and T cell responses, and are the most potent antigen-presenting cells. Brucella spp., which is an intracellular facultative and stealthy pathogen, is able to evade the bactericidal activities of professional phagocytes. Several studies have demonstrated that Brucella can survive and replicate intracellularly, thereby provoking impaired maturation of DCs. Therefore, the interaction between DCs and Brucella becomes an interesting model to study the immune response. In this review, we first will describe the most common techniques for DCs differentiation in vitro as well as general features of brucellosis. Then, the interaction of DCs and Brucella, including pathogen recognition, molecular mechanisms of bacterial pathogenesis, and intracellular trafficking of Brucella to subvert innate response, will be reviewed. Finally, we will debate diversity in immunological DC response and the controversial role of DC activation against Brucella infection.

Center for Molecular Medicine and Infectious Diseases Center for One Health Virginia Maryland College of Veterinary Medicine Virginia Tech Blacksburg VA 24061 0442 USA Department of Large Animal Clinical Sciences Virginia Maryland College of Veterinary Medicine Virginia Tech Blacksburg VA 24061 0442 USA

Departamento de Biología Celular Centro de Investigación y de Estudios Avanzados Instituto Politécnico Nacional CINVESTAV IPN Av IPN No 2508 Zacatenco C P 07330 Mexico city Mexico

Departamento de Biología Celular Centro de Investigación y de Estudios Avanzados Instituto Politécnico Nacional CINVESTAV IPN Av IPN No 2508 Zacatenco C P 07330 Mexico city Mexico Departamento de Microbiología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Prolongación de Carpio y Plan de Ayala S N Santo Tomás 11340 Mexico city Mexico

Departamento de Innovación Biomédica Centro de Investigación Científica y de Educación Superior de Ensenada Carretera Ensenada Tijuana 3918 Zona Playitas 22860 Ensenada Baja California Mexico

Departamento de Microbiología e Inmunología Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Coyoacán 04510 Mexico city Mexico

Departamento de Microbiología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Prolongación de Carpio y Plan de Ayala S N Santo Tomás 11340 Mexico city Mexico

Departamento de Microbiología Facultad de Medicina Universidad Autónoma de Nuevo León Avenida Francisco 1 Madero y Dr Aguirre Pequeño S N Mitras Centro 64460 Monterrey Nuevo León Mexico

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20024252
003      
CZ-PrNML
005      
20201208102224.0
007      
ta
008      
201208s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s12223-019-00691-6 $2 doi
035    __
$a (PubMed)30783994
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Avila-Calderón, Eric Daniel $u Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, CINVESTAV-IPN, Av. IPN No 2508, Zacatenco, C.P 07330, Mexico city, Mexico. Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Santo Tomás, 11340, Mexico city, Mexico.
245    10
$a Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen / $c ED. Avila-Calderón, L. Flores-Romo, W. Sharon, L. Donis-Maturano, MA. Becerril-García, MGA. Arreola, BA. Reynoso, FS. Güemes, A. Contreras-Rodríguez,
520    9_
$a As dendritic cells (DCs) are among the first cells to encounter antigens, these cells trigger both innate and T cell responses, and are the most potent antigen-presenting cells. Brucella spp., which is an intracellular facultative and stealthy pathogen, is able to evade the bactericidal activities of professional phagocytes. Several studies have demonstrated that Brucella can survive and replicate intracellularly, thereby provoking impaired maturation of DCs. Therefore, the interaction between DCs and Brucella becomes an interesting model to study the immune response. In this review, we first will describe the most common techniques for DCs differentiation in vitro as well as general features of brucellosis. Then, the interaction of DCs and Brucella, including pathogen recognition, molecular mechanisms of bacterial pathogenesis, and intracellular trafficking of Brucella to subvert innate response, will be reviewed. Finally, we will debate diversity in immunological DC response and the controversial role of DC activation against Brucella infection.
650    _2
$a zvířata $7 D000818
650    _2
$a Brucella $x imunologie $x patogenita $7 D002002
650    _2
$a brucelóza $x imunologie $7 D002006
650    _2
$a cytoplazma $x mikrobiologie $7 D003593
650    _2
$a dendritické buňky $x mikrobiologie $7 D003713
650    _2
$a interakce hostitele a patogenu $x imunologie $7 D054884
650    _2
$a lidé $7 D006801
650    _2
$a myši $7 D051379
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Flores-Romo, Leopoldo $u Departamento de Biología Celular, Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, CINVESTAV-IPN, Av. IPN No 2508, Zacatenco, C.P 07330, Mexico city, Mexico.
700    1_
$a Sharon, Witonsky $u Center for Molecular Medicine and Infectious Diseases/Center for One Health, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061-0442, USA. Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061-0442, USA.
700    1_
$a Donis-Maturano, Luis $u Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Carretera Ensenada-Tijuana 3918, Zona Playitas, 22860, Ensenada, Baja California, Mexico.
700    1_
$a Becerril-García, Miguel Angel $u Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Avenida Francisco I Madero y Dr. Aguirre Pequeño S/N Mitras Centro, 64460, Monterrey, Nuevo León, Mexico.
700    1_
$a Arreola, Ma Guadalupe Aguilera $u Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Santo Tomás, 11340, Mexico city, Mexico.
700    1_
$a Reynoso, Beatriz Arellano $u Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico city, Mexico.
700    1_
$a Güemes, Francisco Suarez $u Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico city, Mexico.
700    1_
$a Contreras-Rodríguez, Araceli $u Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Santo Tomás, 11340, Mexico city, Mexico. aracelicontreras21@gmail.com.
773    0_
$w MED00011005 $t Folia microbiologica $x 1874-9356 $g Roč. 65, č. 1 (2020), s. 1-16
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30783994 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20201208 $b ABA008
991    __
$a 20201208102220 $b ABA008
999    __
$a ok $b bmc $g 1593207 $s 1114933
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 65 $c 1 $d 1-16 $e 20190219 $i 1874-9356 $m Folia microbiologica $n Folia microbiol. (Prague) $x MED00011005
LZP    __
$a Pubmed-20201208

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...