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Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19

A. Klocperk, Z. Parackova, J. Dissou, H. Malcova, P. Pavlicek, T. Vymazal, P. Dolezalova, A. Sediva,

. 2020 ; 11 (-) : 1665. [pub] 20200703

Jazyk angličtina Země Švýcarsko

Typ dokumentu kazuistiky, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20024905

We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.

Citace poskytuje Crossref.org

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