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A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community)

C. Orengo, S. Velankar, S. Wodak, V. Zoete, AMJJ. Bonvin, A. Elofsson, KA. Feenstra, DL. Gerloff, T. Hamelryck, JM. Hancock, M. Helmer-Citterich, A. Hospital, M. Orozco, A. Perrakis, M. Rarey, C. Soares, JL. Sussman, JM. Thornton, P. Tuffery, G....

. 2020 ; 9 (-) : . [pub] 20200422

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025075

Structural bioinformatics provides the scientific methods and tools to analyse, archive, validate, and present the biomolecular structure data generated by the structural biology community. It also provides an important link with the genomics community, as structural bioinformaticians also use the extensive sequence data to predict protein structures and their functional sites. A very broad and active community of structural bioinformaticians exists across Europe, and 3D-Bioinfo will establish formal platforms to address their needs and better integrate their activities and initiatives. Our mission will be to strengthen the ties with the structural biology research communities in Europe covering life sciences, as well as chemistry and physics and to bridge the gap between these researchers in order to fully realize the potential of structural bioinformatics. Our Community will also undertake dedicated educational, training and outreach efforts to facilitate this, bringing new insights and thus facilitating the development of much needed innovative applications e.g. for human health, drug and protein design. Our combined efforts will be of critical importance to keep the European research efforts competitive in this respect. Here we highlight the major European contributions to the field of structural bioinformatics, the most pressing challenges remaining and how Europe-wide interactions, enabled by ELIXIR and its platforms, will help in addressing these challenges and in coordinating structural bioinformatics resources across Europe. In particular, we present recent activities and future plans to consolidate an ELIXIR 3D-Bioinfo Community in structural bioinformatics and propose means to develop better links across the community. These include building new consortia, organising workshops to establish data standards and seeking community agreement on benchmark data sets and strategies. We also highlight existing and planned collaborations with other ELIXIR Communities and other European infrastructures, such as the structural biology community supported by Instruct-ERIC, with whom we have synergies and overlapping common interests.

Bijvoet Center Faculty of Science Chemistry Utrecht University Utrecht 3584CH The Netherlands

Bioinformatics center Department of Biology University of Copenhagen Copenhagen DK 2200 Denmark

Department of Biology University of Rome Tor Vergata Rome 1 00133 Italy

Department of Oncology Lausanne University Swiss Institute of Bioinformatics Lausanne Switzerland

Department of Structural Biology Weizmann Institute of Science Rehovot 76100 Israel

Dept Computer Science Center for Integrative Bioinformatics VU Vrije Universiteit Amsterdam 1081 HV The Netherlands

ELIXIR Hub ELIXIR Hinxton UK

European Molecular Biology Laboratory European Bioinformatics Institute Hinxton CB10 1SD UK

FBMM Biocenter Oulu University of Oulu Oulu Finland

Institute for Research in Biomedicine The Barcelona Institute of Science and Technology Barcelona 08028 Spain

Institute of Biotechnology of the Czech Academy of Sciences Vestec CZ 25250 Czech Republic

Instituto de Tecnologia Química e Biológica Antonio Xavier Universidade Nova de Lisboa Lisbon Portugal

Luxembourg Centre for Systems Biomedicine University of Luxembourg Belvaux L 4367 Luxembourg

Membrane Bioinformatics Research Group Institute of Enzymology Budapest H 1117 Hungary

Netherlands Cancer Institute and Oncode Institute Utrecht The Netherlands

Protein Data Bank in Europe European Molecular Biology Laboratory European Bioinformatics Institute Hinxton CB10 1SD UK

Ressource Parisienne en Bioinformatique Structurale Université de Paris Paris F 75205 France

Science for Life Laboratory Stockholm University Solna S 17121 Sweden

Structural and Molecular Biology Department University College London UK

Structural Bioinformatics Laboratory Åbo Akademi University Turku FI 20500 Finland

VIB VUB Center for Structural Biology Brussels Belgium

ZBH Center for Bioinformatics Universität Hamburg Hamburg D 20146 Germany

Citace poskytuje Crossref.org

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