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Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes
P. Bednařík, PG. Henry, A. Khowaja, N. Rubin, A. Kumar, D. Deelchand, LE. Eberly, E. Seaquist, G. Öz, A. Moheet,
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
P41 EB027061
NIBIB NIH HHS - United States
UL1 TR002494
NCATS NIH HHS - United States
KL2 TR000113
NCATS NIH HHS - United States
P30 NS076408
NINDS NIH HHS - United States
R01 NS035192
NINDS NIH HHS - United States
KL2 TR002492
NCATS NIH HHS - United States
P41 EB015894
NIBIB NIH HHS - United States
S10 OD017974
NIH HHS - United States
NLK
Free Medical Journals
from 1997 to 1 year ago
ProQuest Central
from 2017-01-01 to 2020-12-31
Health & Medicine (ProQuest)
from 2017-01-01 to 2020-12-31
PubMed
31637440
DOI
10.1210/clinem/dgz062
Knihovny.cz E-resources
- MeSH
- Diabetes Mellitus, Type 1 complications diagnostic imaging metabolism MeSH
- Adult MeSH
- Glucose metabolism MeSH
- Glucose Clamp Technique MeSH
- Hippocampus diagnostic imaging metabolism MeSH
- Hyperglycemia etiology metabolism MeSH
- Hypoglycemia etiology metabolism MeSH
- Kinetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Up-Regulation MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
CONTEXT: Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown. OBJECTIVE: To test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated in T1D with IAH. DESIGN AND PARTICIPANTS: Hippocampal neurochemical profile was measured with single-voxel magnetic resonance spectroscopy at 3T during euglycemia in 18 healthy controls (HC), 10 T1D with IAH, and 12 T1D with normal awareness to hypoglycemia (NAH). Additionally, 12 HC, 8 T1D-IAH, and 6 T1D-NAH were scanned during hyperglycemia to assess hippocampal glucose transport with metabolic modeling. SETTING: University medical center. MAIN OUTCOME MEASURES: Concentrations of hippocampal neurochemicals measured during euglycemia and ratios of maximal transport rate to cerebral metabolic rate of glucose (Tmax/CMRGlc), derived from magnetic resonance spectroscopy-measured hippocampal glucose as a function of plasma glucose. RESULTS: Comparison of hippocampal neurochemical profile revealed no group differences (HC, T1D, T1D-IAH, and T1D-NAH). The ratio Tmax/CMRGlc was not significantly different between the groups, T1D-IAH (1.58 ± 0.09) and HC (1.65 ± 0.07, P = 0.54), between T1D-NAH (1.50 ± 0.09) and HC (P = 0.19), and between T1D-IAH and T1D-NAH (P = 0.53). CONCLUSIONS: Subjects with T1D with sufficient exposure to recurrent hypoglycemia to create IAH did not have alteration of Tmax/CMRglc or neurochemical profile compared with participants with T1D-NAH or HC.
References provided by Crossref.org
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- $a Bednařík, Petr $u Center for Magnetic Reson ance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota. Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, Minnesota. High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Department of Imaging Methods, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
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- $a Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes / $c P. Bednařík, PG. Henry, A. Khowaja, N. Rubin, A. Kumar, D. Deelchand, LE. Eberly, E. Seaquist, G. Öz, A. Moheet,
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- $a CONTEXT: Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during future hypoglycemia in subjects with T1D and impaired awareness of hypoglycemia (IAH). The effect of T1D on hippocampal neurochemical profile and glucose transport is unknown. OBJECTIVE: To test the hypothesis that hippocampal neurochemical composition is altered in T1D and glucose transport is upregulated in T1D with IAH. DESIGN AND PARTICIPANTS: Hippocampal neurochemical profile was measured with single-voxel magnetic resonance spectroscopy at 3T during euglycemia in 18 healthy controls (HC), 10 T1D with IAH, and 12 T1D with normal awareness to hypoglycemia (NAH). Additionally, 12 HC, 8 T1D-IAH, and 6 T1D-NAH were scanned during hyperglycemia to assess hippocampal glucose transport with metabolic modeling. SETTING: University medical center. MAIN OUTCOME MEASURES: Concentrations of hippocampal neurochemicals measured during euglycemia and ratios of maximal transport rate to cerebral metabolic rate of glucose (Tmax/CMRGlc), derived from magnetic resonance spectroscopy-measured hippocampal glucose as a function of plasma glucose. RESULTS: Comparison of hippocampal neurochemical profile revealed no group differences (HC, T1D, T1D-IAH, and T1D-NAH). The ratio Tmax/CMRGlc was not significantly different between the groups, T1D-IAH (1.58 ± 0.09) and HC (1.65 ± 0.07, P = 0.54), between T1D-NAH (1.50 ± 0.09) and HC (P = 0.19), and between T1D-IAH and T1D-NAH (P = 0.53). CONCLUSIONS: Subjects with T1D with sufficient exposure to recurrent hypoglycemia to create IAH did not have alteration of Tmax/CMRglc or neurochemical profile compared with participants with T1D-NAH or HC.
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