Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female
Language English Country United States Media print-electronic
Document type Case Reports, Journal Article
Grant support
130717
Grantová Agentura, Univerzita Karlova
UNCE 204021
Charles University Center of Excellence grant
PROGRES Q26/LF1
Ministry of Education, Youth and Sports Institutional Support for Long-term Development of Research Organizations
PROGRES Q28/LF1
Ministry of Education, Youth and Sports Institutional Support for Long-term Development of Research Organizations
PubMed
29101436
DOI
10.1007/s00266-017-1012-y
PII: 10.1007/s00266-017-1012-y
Knihovny.cz E-resources
- Keywords
- Breast implant-associated anaplastic large-cell lymphoma, Silicone breast implants, Transgender patient,
- MeSH
- Lymphoma, Large-Cell, Anaplastic diagnostic imaging etiology therapy MeSH
- Cyclophosphamide MeSH
- Doxorubicin MeSH
- Breast Implantation adverse effects methods MeSH
- Immunohistochemistry MeSH
- Biopsy, Needle MeSH
- Combined Modality Therapy MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Breast Neoplasms diagnostic imaging etiology therapy MeSH
- Follow-Up Studies MeSH
- Device Removal MeSH
- Positron Emission Tomography Computed Tomography MeSH
- Prednisone MeSH
- Antineoplastic Combined Chemotherapy Protocols MeSH
- Breast Implants adverse effects MeSH
- Silicone Gels adverse effects MeSH
- Transgender Persons MeSH
- Vincristine MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Cyclophosphamide MeSH
- Doxorubicin MeSH
- Prednisone MeSH
- Silicone Gels MeSH
- Vincristine MeSH
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T cell lymphoma. BIA-ALCL is a disease of the fibrous capsule surrounding the implant and occurs in patients after both breast reconstruction and augmentation. More than 300 cases have been reported so far, including two in a transgender patient. Here we describe BIA-ALCL presented with a mass in a transgender patient and the first case of BIA-ALCL in the Czech Republic. In 2007, a 33-year-old transgender male to female underwent bilateral breast augmentation as a part of his transformation to female. In June 2014, the patient developed a 5-cm tumorous mass in her left breast. Magnetic resonance imaging of the chest revealed a ruptured implant and a tumorous mass penetrating into the capsule and infiltrating the pectoral muscle. An R0 surgery was indicated-the implant, silicone gel and capsule were removed, and the tumorous mass was resected together with a part of the pectoral muscle. Histology revealed anaplastic large-cell lymphoma. The patient underwent standard staging procedures for lymphoma including a bone marrow trephine biopsy, which confirmed stage IE. The patient was treated with the standard chemotherapy for systemic ALCL-6 cycles of CHOP-21. The patient was tumor-free at the 2-year follow-up. BIA-ALCL has been reported mostly in women who received implants for either reconstructive or aesthetic augmentation. This is the third report of BIA-ALCL in a transgender person, the first in the Czech Republic. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
3rd Faculty of Medicine Charles University Ruska 87 100 00 Prague Czech Republic
Department of Pathology Prague AeskuLab Pathology Evropska 2589 33b 100 06 Prague Czech Republic
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