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EUFOREA consensus on biologics for CRSwNP with or without asthma
WJ. Fokkens, V. Lund, C. Bachert, J. Mullol, L. Bjermer, J. Bousquet, GW. Canonica, L. Deneyer, M. Desrosiers, Z. Diamant, J. Han, E. Heffler, C. Hopkins, R. Jankowski, G. Joos, A. Knill, J. Lee, SE. Lee, G. Mariën, B. Pugin, B. Senior, SF. Seys,...
Jazyk angličtina Země Dánsko
Typ dokumentu konsensus - konference, časopisecké články, přehledy
PubMed
31090937
DOI
10.1111/all.13875
Knihovny.cz E-zdroje
- MeSH
- biologické přípravky aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- bronchiální astma komplikace MeSH
- chronická nemoc MeSH
- klinické rozhodování MeSH
- komorbidita MeSH
- lidé MeSH
- management nemoci MeSH
- nosní polypy komplikace MeSH
- rýma komplikace farmakoterapie MeSH
- sinusitida komplikace farmakoterapie MeSH
- výsledek terapie MeSH
- výzkum MeSH
- zdravotnické služby - potřeby a požadavky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- konsensus - konference MeSH
- přehledy MeSH
Novel therapies such as type 2 targeting biologics are emerging treatment options for patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely uncontrolled patients. The majority of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and over half of patients with asthma show a type 2 inflammatory signature in sinonasal mucosa and/or lungs. Importantly, both chronic respiratory diseases are frequent comorbidities, ensuring alleviation of both upper and lower airway pathology by systemic biological therapy. Type 2-targeting biologics such as anti-IgE, anti-IL4Rα, anti-IL5, and anti-IL5Rα have entered the market for selected pheno/endotypes of asthma patients and may soon also become available for CRSwNP patients. Given the high prevalence of chronic respiratory diseases and the high cost associated with biologics, patient selection is crucial in order to implement such therapies into chronic respiratory disease care pathways. The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) organized a multidisciplinary Expert Board Meeting to discuss the positioning of biologics into the care pathways for CRSwNP patients with and without comorbid asthma.
Department of Otolaryngology Head and Neck Surgery Eastern Virginia Medical School Norfolk Virginia
Department of Respiratory Medicine and Allergology Lund University Lund Sweden
Department of Respiratory Medicine Ghent University Hospital Gent Belgium
ENT Department University Hospital of Nancy Brabois ILM Nancy France
European Forum for Research and Education in Allergy and Airway Diseases Brussels Belgium
Guy's and St Thomas' NHS Foundation Trust London UK
Personalized Medicine Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano Italy
Royal National Throat Nose and Ear Hospital University College London Hospitals London UK
Citace poskytuje Crossref.org
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- $a Fokkens, Wytske J $u Department of Otorhinolaryngology, Amsterdam University Medical Centres, Location AMC Amsterdam, Amsterdam, The Netherlands. European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Brussels, Belgium.
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- $a Novel therapies such as type 2 targeting biologics are emerging treatment options for patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely uncontrolled patients. The majority of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and over half of patients with asthma show a type 2 inflammatory signature in sinonasal mucosa and/or lungs. Importantly, both chronic respiratory diseases are frequent comorbidities, ensuring alleviation of both upper and lower airway pathology by systemic biological therapy. Type 2-targeting biologics such as anti-IgE, anti-IL4Rα, anti-IL5, and anti-IL5Rα have entered the market for selected pheno/endotypes of asthma patients and may soon also become available for CRSwNP patients. Given the high prevalence of chronic respiratory diseases and the high cost associated with biologics, patient selection is crucial in order to implement such therapies into chronic respiratory disease care pathways. The European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) organized a multidisciplinary Expert Board Meeting to discuss the positioning of biologics into the care pathways for CRSwNP patients with and without comorbid asthma.
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