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Bioactive peptides and proteins as alternative antiplatelet drugs

KRR. Rengasamy, H. Khan, I. Ahmad, D. Lobine, F. Mahomoodally, S. Suroowan, STS. Hassan, S. Xu, S. Patel, M. Daglia, SM. Nabavi, SK. Pandian,

. 2019 ; 39 (6) : 2153-2171. [pub] 20190422

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025548

Grantová podpora
18CDA34110359 American Heart Association-American Stroke Association - United States

Antiplatelet drugs reduce the risks associated with atherothrombotic events and show various applications in diverse cardiovascular diseases including myocardial infarctions. Efficacy of the current antiplatelet medicines including aspirin, clopidogrel, prasugrel and ticagrelor, and the glycoprotein IIb/IIIa antagonists, are limited due to their increased risks of bleeding, and antiplatelet drug resistance. Hence, it is important to develop new effective antiplatelet drugs, with fewer side-effects. The vast repertoire of natural peptides can be explored towards this goal. Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents. Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stages. This review also describes the antiplatelet mechanisms of the peptides, emphasizing the signaling pathways intervened by them. Also, the hurdles encountered during the development of peptides into antiplatelet drugs have been listed. Finally, hitherto unexplored peptides with the potential to prevent platelet aggregation are explored.

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$a Khan, Haroon $u Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan.
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$a Patel, Seema $u Bioinformatics and Medical Informatics Research Center, San Diego State University, San Diego, California.
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