-
Je něco špatně v tomto záznamu ?
The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature
M. Jarošová, K. Plevová, J. Kotašková, M. Doubek, Š. Pospíšilová,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- abnormální karyotyp * MeSH
- chromozomální aberace * MeSH
- chronická lymfatická leukemie diagnóza genetika mortalita terapie MeSH
- cytogenetické vyšetření metody MeSH
- genetická predispozice k nemoci MeSH
- genetické asociační studie MeSH
- klinické rozhodování MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- management nemoci MeSH
- prognóza MeSH
- progrese nemoci MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20025625
- 003
- CZ-PrNML
- 005
- 20201222155318.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/10428194.2019.1576038 $2 doi
- 035 __
- $a (PubMed)30773964
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Jarošová, Marie $u Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno , Brno , Czech Republic. Center of Molecular Biology, CEITEC, Masaryk University , Brno , Czech Republic.
- 245 14
- $a The importance of complex karyotype in prognostication and treatment of chronic lymphocytic leukemia (CLL): a comprehensive review of the literature / $c M. Jarošová, K. Plevová, J. Kotašková, M. Doubek, Š. Pospíšilová,
- 520 9_
- $a Cytogenetic examination and the detection of chromosomal aberrations in chronic lymphocytic leukemia (CLL) is an integral part of prognostic stratification and treatment decisions. Improvements in cytogenetic methods, notably the introduction of the cell stimulation method, have led to the detection of chromosomal aberrations in 80% of CLL cases. A comprehensive analysis of cytogenetic aberrations recently showed that complex karyotypes (CKs) defined as the detection of either three or more or five or more chromosomal changes in a karyotype have a poor prognostic impact. The current efforts at the international level are focused on the goal of including CK assessment among prognostic markers for CLL patients at diagnosis as well as after treatment. This review of the literature documents the clinical importance of CK findings in CLL and the necessity of including this factor in other poor prognostic indicators.
- 650 12
- $a abnormální karyotyp $7 D059786
- 650 12
- $a chromozomální aberace $7 D002869
- 650 _2
- $a klinické rozhodování $7 D000066491
- 650 _2
- $a kombinovaná terapie $7 D003131
- 650 _2
- $a cytogenetické vyšetření $x metody $7 D020732
- 650 _2
- $a management nemoci $7 D019468
- 650 _2
- $a progrese nemoci $7 D018450
- 650 _2
- $a genetické asociační studie $7 D056726
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a chronická lymfatická leukemie $x diagnóza $x genetika $x mortalita $x terapie $7 D015451
- 650 _2
- $a prognóza $7 D011379
- 650 _2
- $a výsledek terapie $7 D016896
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Plevová, Karla $u Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno , Brno , Czech Republic. Center of Molecular Biology, CEITEC, Masaryk University , Brno , Czech Republic.
- 700 1_
- $a Kotašková, Jana $u Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno , Brno , Czech Republic. Center of Molecular Biology, CEITEC, Masaryk University , Brno , Czech Republic.
- 700 1_
- $a Doubek, Michael $u Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno , Brno , Czech Republic. Center of Molecular Biology, CEITEC, Masaryk University , Brno , Czech Republic.
- 700 1_
- $a Pospíšilová, Šárka $u Department of Internal Medicine - Hematology and Oncology, Medical Faculty MU and University Hospital Brno , Brno , Czech Republic. Center of Molecular Biology, CEITEC, Masaryk University , Brno , Czech Republic.
- 773 0_
- $w MED00003140 $t Leukemia & lymphoma $x 1029-2403 $g Roč. 60, č. 10 (2019), s. 2348-2355
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30773964 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201222155314 $b ABA008
- 999 __
- $a ok $b bmc $g 1599770 $s 1116311
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 60 $c 10 $d 2348-2355 $e 20190218 $i 1029-2403 $m Leukemia & lymphoma $n Leuk Lymphoma $x MED00003140
- LZP __
- $a Pubmed-20201125
