Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms

B. Krajcovic, I. Fajnerova, J. Horacek, E. Kelemen, S. Kubik, J. Svoboda, A. Stuchlik,

. 2019 ; 226 (4) : e13282. [pub] 20190522

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025726

Grantová podpora
16-13399S Grantová Agentura České Republiky - International
17-04047S Grantová Agentura České Republiky - International
17-30833A Agentura zdravotnického výzkumu (AZV) - International
1792218 Grantová Agentura, Univerzita Karlova - International
17-04047S Czech Science Foundation - International
17-30833A Czech Science Foundation - International
16-13399S Charles University - International
67985823 Charles University - International
Czech Academy of Sciences - International
LO1611 NIMH NIH HHS - United States
Ministry of Education - International
NV17-30833A MZ0 CEP - Centrální evidence projektů

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large-scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive-behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20025726
003      
CZ-PrNML
005      
20201222154049.0
007      
ta
008      
201125s2019 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/apha.13282 $2 doi
035    __
$a (PubMed)31002202
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Krajcovic, Branislav $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Third Faculty of Medicine, Charles University, Prague, Czech Republic.
245    10
$a Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms / $c B. Krajcovic, I. Fajnerova, J. Horacek, E. Kelemen, S. Kubik, J. Svoboda, A. Stuchlik,
520    9_
$a Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large-scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive-behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.
650    _2
$a zvířata $7 D000818
650    _2
$a mozek $x patofyziologie $7 D001921
650    _2
$a lidé $7 D006801
650    _2
$a nervová síť $x patofyziologie $7 D009415
650    _2
$a nervové dráhy $x patofyziologie $7 D009434
650    _2
$a neurony $x fyziologie $7 D009474
650    _2
$a schizofrenie $x patofyziologie $7 D012559
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Fajnerova, Iveta $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Research Programme 3 - Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Klecany, Czech Republic.
700    1_
$a Horacek, Jiri $u Third Faculty of Medicine, Charles University, Prague, Czech Republic. Research Programme 3 - Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Klecany, Czech Republic.
700    1_
$a Kelemen, Eduard $u Research Programme 1 - Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic.
700    1_
$a Kubik, Stepan $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Svoboda, Jan $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Stuchlik, Ales $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
773    0_
$w MED00154561 $t Acta physiologica (Oxford, England) $x 1748-1716 $g Roč. 226, č. 4 (2019), s. e13282
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31002202 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201222154044 $b ABA008
999    __
$a ok $b bmc $g 1599871 $s 1116412
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 226 $c 4 $d e13282 $e 20190522 $i 1748-1716 $m Acta physiologica $n Acta Physiol $x MED00154561
GRA    __
$a 16-13399S $p Grantová Agentura České Republiky $2 International
GRA    __
$a 17-04047S $p Grantová Agentura České Republiky $2 International
GRA    __
$a 17-30833A $p Agentura zdravotnického výzkumu (AZV) $2 International
GRA    __
$a 1792218 $p Grantová Agentura, Univerzita Karlova $2 International
GRA    __
$a 17-04047S $p Czech Science Foundation $2 International
GRA    __
$a 17-30833A $p Czech Science Foundation $2 International
GRA    __
$a 16-13399S $p Charles University $2 International
GRA    __
$a 67985823 $p Charles University $2 International
GRA    __
$p Czech Academy of Sciences $2 International
GRA    __
$a LO1611 $p NIMH NIH HHS $2 United States
GRA    __
$p Ministry of Education $2 International
GRA    __
$a NV17-30833A $p MZ0
LZP    __
$a Pubmed-20201125

Najít záznam

Citační ukazatele

Možnosti archivace