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Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms

B. Krajcovic, I. Fajnerova, J. Horacek, E. Kelemen, S. Kubik, J. Svoboda, A. Stuchlik,

. 2019 ; 226 (4) : e13282. [pub] 20190522

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc20025726

Grant support
16-13399S Grantová Agentura České Republiky - International
17-04047S Grantová Agentura České Republiky - International
17-30833A Agentura zdravotnického výzkumu (AZV) - International
1792218 Grantová Agentura, Univerzita Karlova - International
17-04047S Czech Science Foundation - International
17-30833A Czech Science Foundation - International
16-13399S Charles University - International
67985823 Charles University - International
Czech Academy of Sciences - International
LO1611 NIMH NIH HHS - United States
Ministry of Education - International
NV17-30833A MZ0 CEP Register

Despite the substantial knowledge accumulated by past research, the exact mechanisms of the pathogenesis of schizophrenia and causal treatments still remain unclear. Deficits of cognition and information processing in schizophrenia are today often viewed as the primary and core symptoms of this devastating disorder. These deficits likely result from disruptions in the coordination of neuronal and neural activity. The aim of this review is to bring together convergent evidence of discoordinated brain circuits in schizophrenia at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large-scale brain networks. We show how these aberrations could underlie deficits in cognitive control and other higher order cognitive-behavioural functions. Converging evidence from both animal models and patients with schizophrenia is presented in an effort to gain insight into common features of deficits in the brain information processing in this disorder, marked by disruption of several neurotransmitter and signalling systems and severe behavioural outcomes.

References provided by Crossref.org

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