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Francisella tularensis Periprosthetic Joint Infections Diagnosed with Growth in Cultures
A. Chrdle, T. Trnka, D. Musil, SF. Fucentese, P. Bode, PM. Keller, Y. Achermann,
Language English Country United States
Document type Case Reports, Journal Article, Review
NLK
Free Medical Journals
from 1975 to 6 months ago
Freely Accessible Science Journals
from 1995 to 6 months ago
PubMed Central
from 1975 to 1 year ago
Europe PubMed Central
from 1975 to 6 months ago
Open Access Digital Library
from 1975-01-01
Open Access Digital Library
from 1975-01-01
PubMed
31189580
DOI
10.1128/jcm.00339-19
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents therapeutic use MeSH
- Bacteriological Techniques MeSH
- Francisella tularensis MeSH
- Prosthesis-Related Infections diagnosis drug therapy microbiology MeSH
- Knee Joint drug effects microbiology MeSH
- Humans MeSH
- Antibodies, Bacterial blood MeSH
- Retrospective Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Synovial Fluid microbiology MeSH
- Tularemia complications diagnosis drug therapy MeSH
- Treatment Outcome MeSH
- Zoonoses diagnosis drug therapy microbiology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Review MeSH
Tularemia caused by Francisella tularensis is a zoonotic infection of the Northern Hemisphere that mainly affects the skin, lymph nodes, bloodstream, and lungs. Other manifestations of tularemia are very rare, especially those with musculoskeletal involvement. Presenting in 2016, we diagnosed two cases of periprosthetic knee joint infections (PJI) caused by Francisella tularensis in Europe (one in Switzerland and one in the Czech Republic). We found only two other PJI cases in the literature, another knee PJI diagnosed 1999 in Ontario, Canada, and one hip PJI in Illinois, USA, in 2017. Diagnosis was made in all cases by positive microbiological cultures after 3, 4, 7, and 12 days. All were successfully treated, two cases by exchange of the prosthesis, one with debridement and retention, and one with repeated aspiration of the synovial fluid only. Antibiotic treatment was given between 3 weeks and 12 months with either ciprofloxacin-rifampin or with doxycycline alone or doxycycline in combination with gentamicin. Zoonotic infections should be considered in periprosthetic infections in particular in culture-negative PJIs with a positive histology or highly elevated leukocyte levels in synovial aspiration. Here, we recommend prolonging cultivation time up to 14 days, performing specific PCR tests, and/or conducting epidemiologically appropriate serological tests for zoonotic infections, including that for F. tularensis.
Department of Orthopaedics Balgrist University Hospital University of Zurich Zurich Switzerland
Department of Orthopedic Surgery České Budějovice Hospital České Budějovice Czech Republic
Institute of Medical Microbiology University of Zurich Zurich Switzerland
Institute of Pathology University Hospital Zurich University of Zurich Zurich Switzerland
References provided by Crossref.org
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- $a Chrdle, Aleš $u Department of Infectious Diseases, České Budějovice Hospital, České Budějovice, Czech Republic. Faculty of Health and Social Sciences, University of South Bohemia, České Budějovice, Czech Republic. Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.
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- $a Tularemia caused by Francisella tularensis is a zoonotic infection of the Northern Hemisphere that mainly affects the skin, lymph nodes, bloodstream, and lungs. Other manifestations of tularemia are very rare, especially those with musculoskeletal involvement. Presenting in 2016, we diagnosed two cases of periprosthetic knee joint infections (PJI) caused by Francisella tularensis in Europe (one in Switzerland and one in the Czech Republic). We found only two other PJI cases in the literature, another knee PJI diagnosed 1999 in Ontario, Canada, and one hip PJI in Illinois, USA, in 2017. Diagnosis was made in all cases by positive microbiological cultures after 3, 4, 7, and 12 days. All were successfully treated, two cases by exchange of the prosthesis, one with debridement and retention, and one with repeated aspiration of the synovial fluid only. Antibiotic treatment was given between 3 weeks and 12 months with either ciprofloxacin-rifampin or with doxycycline alone or doxycycline in combination with gentamicin. Zoonotic infections should be considered in periprosthetic infections in particular in culture-negative PJIs with a positive histology or highly elevated leukocyte levels in synovial aspiration. Here, we recommend prolonging cultivation time up to 14 days, performing specific PCR tests, and/or conducting epidemiologically appropriate serological tests for zoonotic infections, including that for F. tularensis.
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