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Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

M. Sedighi, A. Zahedi Bialvaei, MR. Hamblin, E. Ohadi, A. Asadi, M. Halajzadeh, V. Lohrasbi, N. Mohammadzadeh, T. Amiriani, M. Krutova, A. Amini, E. Kouhsari,

. 2019 ; 8 (6) : 3167-3181. [pub] 20190405

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20025827

Grantová podpora
R01 AI050875 NIAID NIH HHS - United States
R21 AI121700 NIAID NIH HHS - United States

Successful treatment of cancer remains a challenge, due to the unique pathophysiology of solid tumors, and the predictable emergence of resistance. Traditional methods for cancer therapy including radiotherapy, chemotherapy, and immunotherapy all have their own limitations. A novel approach is bacteriotherapy, either used alone, or in combination with conventional methods, has shown a positive effect on regression of tumors and inhibition of metastasis. Bacteria-assisted tumor-targeted therapy used as therapeutic/gene/drug delivery vehicles has great promise in the treatment of tumors. The use of bacteria only, or in combination with conventional methods was found to be effective in some experimental models of cancer (tumor regression and increased survival rate). In this article, we reviewed the major advantages, challenges, and prospective directions for combinations of bacteria with conventional methods for tumor therapy.

Citace poskytuje Crossref.org

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