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Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics
L. Rárová, B. Ncube, J. Van Staden, R. Fürst, M. Strnad, J. Gruz,
Journal of natural products.
2019 ;
82 (5) :
1372-1376.
[pub] 20190401
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc20025850
- MeSH
- alkaloidy amarylkovitých chemie farmakologie MeSH
- Amaryllidaceae chemie MeSH
- antiflogistika nesteroidní chemie farmakologie MeSH
- buněčná adheze účinky léků MeSH
- buněčné linie MeSH
- endoteliální buňky pupečníkové žíly (lidské) účinky léků MeSH
- fenantridiny chemie farmakologie MeSH
- hmotnostní spektrometrie MeSH
- kořeny rostlin chemie MeSH
- lidé MeSH
- metabolomika * MeSH
- mezibuněčná adhezivní molekula-1 účinky léků metabolismus MeSH
- rostlinné extrakty chemie farmakologie MeSH
- viabilita buněk účinky léků MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.
Citace poskytuje Crossref.org
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- $a Rárová, Lucie $u Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science , Palacký University , Šlechtitelů 27 , CZ-783 71 Olomouc , Czech Republic.
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- $a In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a result, the top-scoring metabolite narciclasine (1) is proposed as the active principle of C. contractus. This was confirmed by comparing the biological effect of crude extract with that of an authentic standard.
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