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Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI

G. De Luca, M. Verdoia, M. Cercek, LO. Jensen, M. Vavlukis, L. Calmac, T. Johnson, GR. Ferrer, V. Ganyukov, W. Wojakowski, T. Kinnaird, C. van Birgelen, Y. Cottin, A. IJsselmuiden, B. Tuccillo, F. Versaci, KJ. Royaards, JT. Berg, M. Laine, M....

. 2020 ; 76 (20) : 2321-2330. [pub] 20201117

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, multicentrická studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc20027643

BACKGROUND: The fear of contagion during the coronavirus disease-2019 (COVID-19) pandemic may have potentially refrained patients with ST-segment elevation myocardial infarction (STEMI) from accessing the emergency system, with subsequent impact on mortality. OBJECTIVES: The ISACS-STEMI COVID-19 registry aims to estimate the true impact of the COVID-19 pandemic on the treatment and outcome of patients with STEMI treated by primary percutaneous coronary intervention (PPCI), with identification of "at-risk" patient cohorts for failure to present or delays to treatment. METHODS: This retrospective registry was performed in European high-volume PPCI centers and assessed patients with STEMI treated with PPPCI in March/April 2019 and 2020. Main outcomes are the incidences of PPCI, delayed treatment, and in-hospital mortality. RESULTS: A total of 6,609 patients underwent PPCI in 77 centers, located in 18 countries. In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio: 0.811; 95% confidence interval: 0.78 to 0.84; p < 0.0001). The heterogeneity among centers was not related to the incidence of death due to COVID-19. A significant interaction was observed for patients with arterial hypertension, who were less frequently admitted in 2020 than in 2019. Furthermore, the pandemic was associated with a significant increase in door-to-balloon and total ischemia times, which may have contributed to the higher mortality during the pandemic. CONCLUSIONS: The COVID-19 pandemic had significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic. (Primary Angioplasty for STEMI During COVID-19 Pandemic [ISACS-STEMI COVID-19] Registry; NCT04412655).

AUSL IRCCS Reggio Emilia Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti Trieste Italy

Azienda Ospedaliero Universitaria Sassari Sassari Italy

Center for Cardiovascular Diseases Ohrid North Macedonia

Center Hospitalier Universitaire de Poitiers Poitiers University Hospital Poitiers France

Central Hospital of Medical University of Lodz Lodz Poland

Centre for Intensive Internal Medicine University Medical Centre Ljubljana Slovenia

Charles University Hospital Prague Czech Republic

Clinic Emergency Hospital of Bucharest Bucharest Romania

Complexo Hospetaliero Universitario La Coruna La Coruna Spain

Department of Cardiology Medisch Spectrum Twente Thoraxcentrum Twente Enschede the Netherlands

Department of Statistical Sciences University of Padova Padova Italy

Division of Cardiology Amphia Hospital Breda the Netherlands

Division of Cardiology Attikon University Hospital Athens Greece

Division of Cardiology Azienda Ospedaliera Ospedali Riuniti Marche Nord Pesaro Italy

Division of Cardiology Azienda Ospedaliero Universitaria Maggiore della Carità Università del Piemonte Orientale Novara Italy

Division of Cardiology Bristol Heart Institute University Hospitals Bristol NHSFT and University of Bristol Bristol United Kingdom

Division of Cardiology CHU Lariboisière AP HP Paris 7 University INSERM UMRS 942 Paris France

Division of Cardiology CHU Timone Aix Marseille Université Marseille France

Division of Cardiology Clinica Villa dei Fiori Acerra Italy

Division of Cardiology Clinical and Experimental Interventional Cardiology University of Saarland Homburg Germany

Division of Cardiology Complejo Hospitalario de Toledo Toledo Spain

Division of Cardiology Groupe Hospitalier Mutualiste de Grenoble Grenoble France

Division of Cardiology Heart Centre Turku University Hospital Turku Finland

Division of Cardiology Helsinki University Central Hospital Helsinki Finland

Division of Cardiology Hospital Cabueñes Gijon Spain

Division of Cardiology Hospital Clinico Universitario de Valencia Spain

Division of Cardiology Hospital de Santa Cruz CHLO Carnaxide Lisbon Portugal

Division of Cardiology Hospital la Paz Madrid Spain

Division of Cardiology Hospital Puerta de Hierro Majadahonda Spain

Division of Cardiology Hospital Puerta del Mar Cadiz Spain

Division of Cardiology Hospital Universitario de Canarias Santa Cruz de Tenerife Spain

Division of Cardiology Jessa Ziekenhuis Hasselt Belgium

Division of Cardiology Juan Ramon Jimenez Hospital Huelva Spain

Division of Cardiology Maasstad Ziekenhuis Rotterdam the Netherlands

Division of Cardiology Medical University of Silezia Katowice Poland

Division of Cardiology Northwest Clinics Alkmaar the Netherlands

Division of Cardiology Odense Universitets Hospital Odense Denmark

Division of Cardiology Ospedale A Manzoni Lecco Italy

Division of Cardiology Ospedale Civico Arnas Palermo Italy

Division of Cardiology Ospedale degli Infermi ASL Biella Biella Italy

Division of Cardiology Ospedale del Mare Napoli Italy

Division of Cardiology Ospedale F Spaziani Frosinone Italy

Division of Cardiology Ospedale G Moscati Aversa Italy

Division of Cardiology Ospedale Maggiore Bologna Italy

Division of Cardiology Ospedale S Maurizio Bolzano Ospedale S Maurizio Bolzano Italy

Division of Cardiology Ospedale San Giovanni di Dio e Ruggi d'Aragona Salerno Italy

Division of Cardiology Ospedale Sant'Anna Ferrara Italy

Division of Cardiology Ospedale Santa Maria della Misericordia Udine Italy

Division of Cardiology Ospedale Santa Maria delle Grazie Pozzuoli Italy

Division of Cardiology Ospedale Santa Maria Goretti Latina Italy

Division of Cardiology Ospedali Riuniti Reggio Calabria Italy

Division of Cardiology Oulu University Hospital Oulu Finland

Division of Cardiology St Antonius Hospital Nieuwegein the Netherlands

Division of Cardiology St Jan Hospital Brugge Belgium

Division of Cardiology State Research Institute for Complex Issues of Cardiovascular Diseases Kemerovo Kemerovo Russia

Division of Cardiology UMC Utrecht the Netherlands

Division of Cardiology University Hospital Dijon France

Division of Cardiology University Hospital of Wales Cardiff United Kingdom

Division of Cardiology Ziekenhuis Netwerk Antwerpen Middelheim Antwerp Belgium

H Universitario y Politécnico La Fe Valencia Spain

Hospital Clínico Universitario Virgen de la Victoria Málaga Spain

Hospital Germans Triasi Pujol Badalona Spain

Institute of Cardiology Jagiellonian University Medical College Krakow Poland

Interventional Cardiology Unit Azienda Ospedaliera Sanitaria Parma Italy

Interventional Cardiology Unit Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy

Interventional Cardiology Unit Heart Disease Institute Hospital Universitari de Bellvitge Barcelona Spain

Invasive Cardiology and Congenital Heart Disease Patras University Hospital Patras Greece

John Radcliffe Hospital Oxford United Kingdom

Mastricht University Medical Center Maastricht the Netherlands

Onze Lieve Vrouwe Gasthuis Amsterdam the Netherlands

Ospedale Santa Chiara Trento Italy

Ospedale Santa Maria della Misericordia Perugia Italy

University Clinic for Cardiology Medical Faculty Ss' Cyril and Methodius University Skopje North Macedonia

University Hospital Birmingham Birmingham United Kingdom

University Hospital Brno Medical Faculty of Masaryk University Brno Czech Republic

University Hospital Munich Ludwig Maximilians University Munich Germany

Citace poskytuje Crossref.org

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$a De Luca, Giuseppe $u Division of Cardiology, Azienda Ospedaliero-Universitaria Maggiore della Carità, Università del Piemonte Orientale, Novara, Italy. Electronic address: giuseppe.deluca@med.uniupo.it.
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$a Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI / $c G. De Luca, M. Verdoia, M. Cercek, LO. Jensen, M. Vavlukis, L. Calmac, T. Johnson, GR. Ferrer, V. Ganyukov, W. Wojakowski, T. Kinnaird, C. van Birgelen, Y. Cottin, A. IJsselmuiden, B. Tuccillo, F. Versaci, KJ. Royaards, JT. Berg, M. Laine, M. Dirksen, M. Siviglia, G. Casella, P. Kala, JL. Díez Gil, A. Banning, V. Becerra, C. De Simone, A. Santucci, X. Carrillo, A. Scoccia, G. Amoroso, A. Lux, T. Kovarnik, P. Davlouros, J. Mehilli, G. Gabrielli, XF. Rios, N. Bakraceski, S. Levesque, G. Cirrincione, V. Guiducci, M. Kidawa, L. Spedicato, L. Marinucci, P. Ludman, F. Zilio, G. Galasso, E. Fabris, M. Menichelli, A. Garcia-Touchard, S. Manzo, G. Caiazzo, J. Moreu, JS. Forés, L. Donazzan, L. Vignali, R. Teles, E. Benit, P. Agostoni, F. Bosa Ojeda, H. Lehtola, S. Camacho-Freiere, A. Kraaijeveld, Y. Antti, M. Boccalatte, P. Deharo, IL. Martínez-Luengas, B. Scheller, D. Alexopoulos, R. Moreno, E. Kedhi, G. Uccello, B. Faurie, A. Gutierrez Barrios, FS. Di Uccio, B. Wilbert, P. Smits, G. Cortese, G. Parodi, D. Dudek,
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$a BACKGROUND: The fear of contagion during the coronavirus disease-2019 (COVID-19) pandemic may have potentially refrained patients with ST-segment elevation myocardial infarction (STEMI) from accessing the emergency system, with subsequent impact on mortality. OBJECTIVES: The ISACS-STEMI COVID-19 registry aims to estimate the true impact of the COVID-19 pandemic on the treatment and outcome of patients with STEMI treated by primary percutaneous coronary intervention (PPCI), with identification of "at-risk" patient cohorts for failure to present or delays to treatment. METHODS: This retrospective registry was performed in European high-volume PPCI centers and assessed patients with STEMI treated with PPPCI in March/April 2019 and 2020. Main outcomes are the incidences of PPCI, delayed treatment, and in-hospital mortality. RESULTS: A total of 6,609 patients underwent PPCI in 77 centers, located in 18 countries. In 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio: 0.811; 95% confidence interval: 0.78 to 0.84; p < 0.0001). The heterogeneity among centers was not related to the incidence of death due to COVID-19. A significant interaction was observed for patients with arterial hypertension, who were less frequently admitted in 2020 than in 2019. Furthermore, the pandemic was associated with a significant increase in door-to-balloon and total ischemia times, which may have contributed to the higher mortality during the pandemic. CONCLUSIONS: The COVID-19 pandemic had significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic. (Primary Angioplasty for STEMI During COVID-19 Pandemic [ISACS-STEMI COVID-19] Registry; NCT04412655).
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$a Verdoia, Monica $u Division of Cardiology, Ospedale degli Infermi, ASL Biella, Biella, Italy.
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$a Cercek, Miha $u Centre for Intensive Internal Medicine, University Medical Centre, Ljubljana, Slovenia.
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$a Jensen, Lisette Okkels $u Division of Cardiology, Odense Universitets Hospital, Odense, Denmark.
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$a Vavlukis, Marija $u University Clinic for Cardiology, Medical Faculty, Ss' Cyril and Methodius University, Skopje, North Macedonia.
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$a Calmac, Lucian $u Clinic Emergency Hospital of Bucharest, Bucharest, Romania.
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$a Johnson, Tom $u Division of Cardiology, Bristol Heart Institute, University Hospitals Bristol NHSFT & University of Bristol, Bristol, United Kingdom.
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$a Ferrer, Gerard Rourai $u Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, Barcelona, Spain.
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$a Ganyukov, Vladimir $u Division of Cardiology, State Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Kemerovo, Russia.
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$a Wojakowski, Wojtek $u Division of Cardiology, Medical University of Silezia, Katowice, Poland.
700    1_
$a Kinnaird, Tim $u Division of Cardiology, University Hospital of Wales, Cardiff, United Kingdom.
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$a van Birgelen, Clemens $u Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, Enschede, the Netherlands.
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$a Cottin, Yves $u Division of Cardiology, University Hospital, Dijon, France.
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$a IJsselmuiden, Alexander $u Division of Cardiology, Amphia Hospital, Breda, the Netherlands.
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$a Tuccillo, Bernardo $u Division of Cardiology, Ospedale del Mare, Napoli, Italy.
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$a Versaci, Francesco $u Division of Cardiology, Ospedale Santa Maria Goretti, Latina, Italy.
700    1_
$a Royaards, Kees-Jan $u Division of Cardiology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.
700    1_
$a Berg, Jurrien Ten $u Division of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands.
700    1_
$a Laine, Mika $u Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
700    1_
$a Dirksen, Maurits $u Division of Cardiology, Northwest Clinics, Alkmaar, the Netherlands.
700    1_
$a Siviglia, Massimo $u Division of Cardiology, Ospedali Riuniti, Reggio Calabria, Italy.
700    1_
$a Casella, Gianni $u Division of Cardiology, Ospedale Maggiore, Bologna, Italy.
700    1_
$a Kala, Petr $u University Hospital Brno, Medical Faculty of Masaryk University Brno, Czech Republic.
700    1_
$a Díez Gil, José Luis $u H. Universitario y Politécnico La Fe, Valencia, Spain.
700    1_
$a Banning, Adrian $u John Radcliffe Hospital, Oxford, United Kingdom.
700    1_
$a Becerra, Victor $u Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain.
700    1_
$a De Simone, Ciro $u Division of Cardiology, Clinica Villa dei Fiori, Acerra, Italy.
700    1_
$a Santucci, Andrea $u Ospedale Santa Maria della Misericordia, Perugia, Italy.
700    1_
$a Carrillo, Xavier $u Hospital Germans Triasi Pujol, Badalona, Spain.
700    1_
$a Scoccia, Alessandra $u Division of Cardiology, Ospedale "Sant'Anna", Ferrara, Italy.
700    1_
$a Amoroso, Giovanni $u Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands.
700    1_
$a Lux, Arpad $u Mastricht University Medical Center, Maastricht, the Netherlands.
700    1_
$a Kovarnik, Tomas $u Charles University Hospital, Prague, Czech Republic.
700    1_
$a Davlouros, Periklis $u Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, Greece.
700    1_
$a Mehilli, Julinda $u University Hospital Munich, Ludwig-Maximilians University, Munich, Germany.
700    1_
$a Gabrielli, Gabriele $u Interventional Cardiology Unit, Azienda Ospedaliero Universitaria "Ospedali Riuniti", Ancona, Italy.
700    1_
$a Rios, Xacobe Flores $u Complexo Hospetaliero Universitario La Coruna, La Coruna, Spain.
700    1_
$a Bakraceski, Nikola $u Center for Cardiovascular Diseases, Ohrid, North Macedonia.
700    1_
$a Levesque, Sébastien $u Center Hospitalier Universitaire de Poitiers, Poitiers, University Hospital, Poitiers, France.
700    1_
$a Cirrincione, Giuseppe $u Division of Cardiology, Ospedale Civico Arnas, Palermo, Italy.
700    1_
$a Guiducci, Vincenzo $u AUSL-IRCCS, Reggio Emilia, Italy.
700    1_
$a Kidawa, Michał $u Central Hospital of Medical University of Lodz, Lodz, Poland.
700    1_
$a Spedicato, Leonardo $u Division of Cardiology, Ospedale "Santa Maria della Misericordia", Udine, Italy.
700    1_
$a Marinucci, Lucia $u Division of Cardiology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro, Italy.
700    1_
$a Ludman, Peter $u University Hospital Birmingham, Birmingham, United Kingdom.
700    1_
$a Zilio, Filippo $u Ospedale Santa Chiara, Trento, Italy.
700    1_
$a Galasso, Gennaro $u Division of Cardiology,Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
700    1_
$a Fabris, Enrico $u Azienda Ospedaliero - Universitaria Ospedali Riuniti, Trieste, Italy.
700    1_
$a Menichelli, Maurizio $u Division of Cardiology, Ospedale "F. Spaziani", Frosinone, Italy.
700    1_
$a Garcia-Touchard, Arturo $u Division of Cardiology, Hospital Puerta de Hierro, Majadahonda, Spain.
700    1_
$a Manzo, Stephane $u Division of Cardiology, CHU Lariboisière, AP-HP, Paris VII University, INSERM UMRS 942, Paris, France.
700    1_
$a Caiazzo, Gianluca $u Division of Cardiology, Ospedale "G Moscati", Aversa, Italy.
700    1_
$a Moreu, Jose $u Division of Cardiology, Complejo Hospitalario de Toledo, Toledo, Spain.
700    1_
$a Forés, Juan Sanchis $u Division of Cardiology, Hospital Clinico Universitario de Valencia, Spain.
700    1_
$a Donazzan, Luca $u Division of Cardiology, Ospedale "S. Maurizio" Bolzano Ospedale "S. Maurizio" Bolzano, Italy.
700    1_
$a Vignali, Luigi $u Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, Italy.
700    1_
$a Teles, Rui $u Division of Cardiology, Hospital de Santa Cruz, CHLO - Carnaxide, Lisbon, Portugal.
700    1_
$a Benit, Edouard $u Division of Cardiology, Jessa Ziekenhuis, Hasselt, Belgium.
700    1_
$a Agostoni, Pierfrancesco $u Division of Cardiology, Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim, Antwerp, Belgium.
700    1_
$a Bosa Ojeda, Francisco $u Division of Cardiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
700    1_
$a Lehtola, Heidi $u Division of Cardiology, Oulu University Hospital, Oulu, Finland.
700    1_
$a Camacho-Freiere, Santiago $u Division of Cardiology, Juan Ramon Jimenez Hospital, Huelva, Spain.
700    1_
$a Kraaijeveld, Adriaan $u Division of Cardiology, UMC Utrecht, the Netherlands.
700    1_
$a Antti, Ylitalo $u Division of Cardiology, Heart Centre, Turku, University Hospital, Turku, Finland.
700    1_
$a Boccalatte, Marco $u Division of Cardiology, Ospedale Santa Maria delle Grazie, Pozzuoli, Italy.
700    1_
$a Deharo, Pierre $u Division of Cardiology, CHU Timone, Aix-Marseille Université, Marseille, France.
700    1_
$a Martínez-Luengas, Iñigo Lozano $u Division of Cardiology, Hospital Cabueñes, Gijon, Spain.
700    1_
$a Scheller, Bruno $u Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg, Germany.
700    1_
$a Alexopoulos, Dimitrios $u Division of Cardiology, Attikon University Hospital, Athens, Greece.
700    1_
$a Moreno, Raul $u Division of Cardiology, Hospital la Paz, Madrid, Spain.
700    1_
$a Kedhi, Elvin $u Division of Cardiology, St-Jan Hospital, Brugge, Belgium.
700    1_
$a Uccello, Giuseppe $u Division of Cardiology, Ospedale "A. Manzoni" Lecco, Italy.
700    1_
$a Faurie, Benjamin $u Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France.
700    1_
$a Gutierrez Barrios, Alejandro $u Division of Cardiology, Hospital Puerta del Mar, Cadiz, Spain.
700    1_
$a Di Uccio, Fortunato Scotto $u Division of Cardiology, Ospedale del Mare, Napoli, Italy.
700    1_
$a Wilbert, Bor $u Division of Cardiology, St Antonius Hospital, Nieuwegein, the Netherlands.
700    1_
$a Smits, Pieter $u Division of Cardiology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.
700    1_
$a Cortese, Giuliana $u Department of Statistical Sciences, University of Padova, Padova, Italy.
700    1_
$a Parodi, Guido $u Azienda Ospedaliero-Universitaria Sassari, Sassari, Italy.
700    1_
$a Dudek, Dariusz $u Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
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