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Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19
J. Brábek, M. Jakubek, F. Vellieux, J. Novotný, M. Kolář, L. Lacina, P. Szabo, K. Strnadová, D. Rösel, B. Dvořánková, K. Smetana,
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články, přehledy
Grantová podpora
"Centre for Tumour Ecology - Research of the Cancer Microenvironment Supporting Cancer Growth and Spread "(No. CZ.02.1.01/0.0/0.0/16_019/0000785)
MŠMT ČR - supported by the Operational Programme Research, Development and Education, by the European Regional Development Fund (ERDF)
BIOCEV (No. CZ.1.05/1.1.00/02.0109)
MŠMT ČR
), "The Equipment for Metabolomics and Cell Analyses" (No. CZ.1.05/2.1.00/19.0400)
MŠMT ČR
PROGRES Q28
Charles University in Prague
NLK
Free Medical Journals
od 2000
Freely Accessible Science Journals
od 2000
PubMed Central
od 2007
Europe PubMed Central
od 2007
ProQuest Central
od 2000-03-01
Open Access Digital Library
od 2000-01-01
Open Access Digital Library
od 2007-01-01
Health & Medicine (ProQuest)
od 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
od 2000
PubMed
33114676
DOI
10.3390/ijms21217937
Knihovny.cz E-zdroje
- MeSH
- COVID-19 MeSH
- interleukin-6 genetika metabolismus MeSH
- koronavirové infekce metabolismus patologie MeSH
- lidé MeSH
- nádory metabolismus patologie MeSH
- pandemie MeSH
- signální transdukce MeSH
- stárnutí metabolismus patologie MeSH
- virová pneumonie metabolismus patologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections.
Citace poskytuje Crossref.org
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