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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
J. Krivanek, RA. Soldatov, ME. Kastriti, T. Chontorotzea, AN. Herdina, J. Petersen, B. Szarowska, M. Landova, VK. Matejova, LI. Holla, U. Kuchler, IV. Zdrilic, A. Vijaykumar, A. Balic, P. Marangoni, OD. Klein, VCM. Neves, V. Yianni, PT. Sharpe,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
R01 HL131768
NHLBI NIH HHS - United States
R35 DE026602
NIDCR NIH HHS - United States
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2019-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
Springer Nature - nature.com Journals - Fully Open Access
od 2010-12-01
- MeSH
- buněčná diferenciace * genetika MeSH
- dospělí MeSH
- epitelové buňky MeSH
- genetická heterogenita MeSH
- kmenové buňky cytologie MeSH
- lidé MeSH
- mezoderm cytologie růst a vývoj metabolismus MeSH
- mladiství MeSH
- mladý dospělý MeSH
- modely u zvířat MeSH
- moláry cytologie růst a vývoj MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- odontoblasty MeSH
- řezáky cytologie růst a vývoj MeSH
- vývojová regulace genové exprese MeSH
- zuby cytologie růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
Centre d'Immunologie de Marseille Luminy Aix Marseille Université INSERM CNRS UMR Marseille France
Department of Biomedical Informatics Harvard Medical School Boston MA USA
Department of Evolutionary Biology University of Vienna Vienna Austria
Department of Neuroscience Karolinska Institutet Stockholm Sweden
Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden
Institute of Animal Physiology and Genetics CAS Brno Czech Republic
Citace poskytuje Crossref.org
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- $a Krivanek, Jan $u Department of Molecular Neuroscience, Center for Brain Research, Medical University of Vienna, Vienna, Austria. Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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- $a Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth / $c J. Krivanek, RA. Soldatov, ME. Kastriti, T. Chontorotzea, AN. Herdina, J. Petersen, B. Szarowska, M. Landova, VK. Matejova, LI. Holla, U. Kuchler, IV. Zdrilic, A. Vijaykumar, A. Balic, P. Marangoni, OD. Klein, VCM. Neves, V. Yianni, PT. Sharpe, T. Harkany, BD. Metscher, M. Bajénoff, M. Mina, K. Fried, PV. Kharchenko, I. Adameyko,
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- $a Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
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