Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
- MeSH
- buněčná diferenciace * genetika MeSH
- dospělí MeSH
- epitelové buňky MeSH
- genetická heterogenita MeSH
- kmenové buňky cytologie MeSH
- lidé MeSH
- mezoderm cytologie růst a vývoj metabolismus MeSH
- mladiství MeSH
- mladý dospělý MeSH
- modely u zvířat MeSH
- moláry cytologie růst a vývoj MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- odontoblasty MeSH
- řezáky cytologie růst a vývoj MeSH
- vývojová regulace genové exprese MeSH
- zuby cytologie růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH