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Autophagosome Biogenesis in Plants: An Actin Cytoskeleton Perspective
P. Wang, E. Gao, PJ. Hussey,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
BB/G006334/1
Biotechnology and Biological Sciences Research Council - United Kingdom
- MeSH
- Autophagy MeSH
- Autophagosomes * metabolism MeSH
- Actin Cytoskeleton * MeSH
- Plants MeSH
- Protein Transport MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
At the subcellular level, the cytoskeleton regulates cell structure, organelle movement, and cytoplasmic streaming. Autophagy is a process to remove unwanted biomaterials or damaged organelles through double membrane compartments known as autophagosomes. Autophagosome biogenesis requires vesicle trafficking between donor and acceptor compartments, membrane expansion, and fusion, which is very likely to be regulated by the cytoskeleton. Recent studies have demonstrated that by knocking out key actin-regulating proteins, autophagosome biogenesis is inhibited. However, the formation of ATG8 positive structures are not affected when the entire actin network is disrupted. Here, we discuss this paradox and propose the function of the actin cytoskeleton in plant autophagy.
References provided by Crossref.org
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- $a Wang, Pengwei $u Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China. Electronic address: wangpengwei@mail.hzau.edu.cn.
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- $a At the subcellular level, the cytoskeleton regulates cell structure, organelle movement, and cytoplasmic streaming. Autophagy is a process to remove unwanted biomaterials or damaged organelles through double membrane compartments known as autophagosomes. Autophagosome biogenesis requires vesicle trafficking between donor and acceptor compartments, membrane expansion, and fusion, which is very likely to be regulated by the cytoskeleton. Recent studies have demonstrated that by knocking out key actin-regulating proteins, autophagosome biogenesis is inhibited. However, the formation of ATG8 positive structures are not affected when the entire actin network is disrupted. Here, we discuss this paradox and propose the function of the actin cytoskeleton in plant autophagy.
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- $a Hussey, Patrick J $u Department of Biosciences, Durham University, South Road, Durham, DH1 3LE, UK; Department of Experimental Plant Biology, Charles University, Faculty of Science, Viničná 5, CZ 128 43 Praha 2, Czechia. Electronic address: p.j.hussey@durham.ac.uk.
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