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TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
J. Remšík, M. Pícková, O. Vacek, R. Fedr, L. Binó, A. Hampl, K. Souček,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
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ProQuest Central
od 2011-01-01
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Health & Medicine (ProQuest)
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Springer Nature OA/Free Journals
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- MeSH
- ataxin-1 metabolismus MeSH
- epitelo-mezenchymální tranzice genetika MeSH
- epitelové buňky patologie MeSH
- experimentální nádory mléčných žláz genetika patologie MeSH
- lidé MeSH
- mléčné žlázy zvířat patologie MeSH
- myši MeSH
- nádorové buněčné linie transplantace MeSH
- nádorové kmenové buňky patologie MeSH
- nádory prsu genetika patologie MeSH
- plasticita buňky genetika MeSH
- receptor erbB-2 genetika MeSH
- regulace genové exprese u nádorů MeSH
- rekombinantní proteiny genetika metabolismus MeSH
- signální transdukce genetika MeSH
- transformující růstový faktor beta genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-β family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-β disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
Citace poskytuje Crossref.org
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- $a Remšík, Ján $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65, Brno, Czech Republic. Center of Biomolecular and Cellular Engineering, International Clinical Research Center, St. Anne's University Hospital Brno, Pekařská 53, 656 91, Brno, Czech Republic. Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
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- $a TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells / $c J. Remšík, M. Pícková, O. Vacek, R. Fedr, L. Binó, A. Hampl, K. Souček,
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- $a The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-β family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-β disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
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