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Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography
G. De Rubeis, AE. Napp, P. Schlattmann, J. Geleijns, M. Laule, H. Dreger, K. Kofoed, M. Sørgaard, T. Engstrøm, HH. Tilsted, A. Boi, M. Porcu, S. Cossa, JF. Rodríguez-Palomares, F. Xavier Valente, A. Roque, G. Feuchtner, F. Plank, C. Štěchovský,...
Jazyk angličtina Země Německo
Typ dokumentu klinické zkoušky, časopisecké články, multicentrická studie
Grantová podpora
603266
European Union
NLK
CINAHL Plus with Full Text (EBSCOhost)
od 2008-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
- MeSH
- CT angiografie metody MeSH
- koronární angiografie metody MeSH
- koronární cévy diagnostické zobrazování MeSH
- lidé středního věku MeSH
- lidé MeSH
- nemoci koronárních tepen diagnóza MeSH
- pilotní projekty MeSH
- reprodukovatelnost výsledků MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- multicentrická studie MeSH
OBJECTIVE: To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study. MATERIALS AND METHODS: From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB). RESULTS: We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13). CONCLUSION: We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations. KEY POINTS: • Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.
Department of Cardiology Aintree University Hospital Longmoor Lane Liverpool L9 7AL UK
Department of Cardiology ALB FILS KLINIKEN GmbH Eichertstrasse 3 73035 Goeppingen Germany
Department of Cardiology Azienda Ospedaliera Brotzu Cagliari CA Italy
Department of Cardiology Basurto University Hospital Avenida Montevideo 18 48013 Bilbao Spain
Department of Cardiology Cardio Med Medical Center 22 decembrie 1989 540156 Targu Mures Romania
Department of Cardiology Charité Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin Germany
Department of Cardiology Clinical Hospital Center Zemun Vukova 9 Belgrade Zemun 11080 Serbia
Department of Cardiology Lithuanian University of Health Sciences Eivelniu 2 50009 Kaunas Lithuania
Department of Cardiology Medical University Innsbruck Anichstr 35 6020 Innsbruck Austria
Department of Cardiology Rigshospitalet Region Hovedstaden Rigshospitalet 9 2100 Copenhagen Denmark
Department of Cardiology St Vincent's University Hospital Belfield Campus 4 Dublin Ireland
Department of Cardiology The Institute of Cardiology in Warsaw Ul Alpejska 42 04 628 Warsaw Poland
Department of Cardiology University Hospital Motol Vuvalu 84 150 06 Prague 5 Czech Republic
Department of Radiology Aintree University Hospital Longmoor Lane Liverpool L9 7AL UK
Department of Radiology ALB FILS KLINIKEN GmbH Eichertstrasse 3 73035 Goeppingen Germany
Department of Radiology Azienda Ospedaliera Brotzu Cagliari CA Italy
Department of Radiology Basurto University Hospital Avenida Montevideo 18 48013 Bilbao Spain
Department of Radiology Charité Universitätsmedizin Berlin Charitéplatz 1 10117 Berlin Germany
Department of Radiology Lithuanian University of Health Sciences Eivelniu 2 50009 Kaunas Lithuania
Department of Radiology Medical University Innsbruck Anichstr 35 6020 Innsbruck Austria
Department of Radiology Sapienza University of Rome Viale Regina Elena 324 00161 Rome Italy
Department of Radiology The Institute of Cardiology in Warsaw Ul Alpejska 42 04 628 Warsaw Poland
Department of Radiology University Hospital Motol Vuvalu 84 150 06 Prague 5 Czech Republic
Department of Radiology University of Leipzig Heart Centre Strümpellstrasse 39 04289 Leipzig Germany
Department of Statistics Informatics and Data Science Jena University Hospital Jena Germany
Heart Centre Turku University Hospital Kiinamyllynkatu 4 8 FI 20120 Turku Finland
Citace poskytuje Crossref.org
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- $a De Rubeis, Gianluca $u Department of Radiology, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.
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- $a Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography / $c G. De Rubeis, AE. Napp, P. Schlattmann, J. Geleijns, M. Laule, H. Dreger, K. Kofoed, M. Sørgaard, T. Engstrøm, HH. Tilsted, A. Boi, M. Porcu, S. Cossa, JF. Rodríguez-Palomares, F. Xavier Valente, A. Roque, G. Feuchtner, F. Plank, C. Štěchovský, T. Adla, S. Schroeder, T. Zelesny, M. Gutberlet, M. Woinke, M. Károlyi, J. Karády, P. Donnelly, P. Ball, J. Dodd, M. Hensey, M. Mancone, A. Ceccacci, M. Berzina, L. Zvaigzne, G. Sakalyte, A. Basevičius, M. Ilnicka-Suckiel, D. Kuśmierz, R. Faria, V. Gama-Ribeiro, I. Benedek, T. Benedek, F. Adjić, M. Čanković, C. Berry, C. Delles, E. Thwaite, G. Davis, J. Knuuti, M. Pietilä, C. Kepka, M. Kruk, R. Vidakovic, AN. Neskovic, I. Lecumberri, I. Diez Gonzales, B. Ruzsics, M. Fisher, M. Dewey, M. Francone, DISCHARGE Trial Group,
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- $a OBJECTIVE: To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study. MATERIALS AND METHODS: From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB). RESULTS: We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13). CONCLUSION: We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations. KEY POINTS: • Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.
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- $a Napp, Adriane E $u Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
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- $a Schlattmann, Peter $u Department of Statistics, Informatics and Data Science, Jena University Hospital, Jena, Germany.
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- $a Geleijns, Jacob $u Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
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- $a Xavier Valente, Filipa $u Department of Cardiology, Hospital Universitari Vall d´Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Passeig de Vall d'Hebron 119, 08035, Barcelona, Spain.
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- $a Roque, Albert $u Department of Radiology, Hospital Universitari Vall d´Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Passeig de Vall d'Hebron 119, 08035, Barcelona, Spain.
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- $a Feuchtner, Gudrun $u Department of Radiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
- 700 1_
- $a Plank, Fabian $u Department of Cardiology, Medical University Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.
- 700 1_
- $a Štěchovský, Cyril $u Department of Cardiology, University Hospital Motol, Vuvalu 84, 150 06, Prague 5, Czech Republic.
- 700 1_
- $a Adla, Theodor $u Department of Radiology, University Hospital Motol, Vuvalu 84, 150 06, Prague 5, Czech Republic.
- 700 1_
- $a Schroeder, Stephen $u Department of Cardiology, ALB FILS KLINIKEN GmbH, Eichertstrasse 3, 73035, Goeppingen, Germany.
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- 700 1_
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- 700 1_
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- $a Kuśmierz, Donata $u Department of Radiology, Wojewodzki Szpital Specjalistyczny We Wroclawiu, Ul. Henryka Michala Kamienskiego, 51124, Wroclaw, Poland.
- 700 1_
- $a Faria, Rita $u Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia, Rua Conceicao Fernandes, 4434 502, Vila Nova de Gaia, Portugal.
- 700 1_
- $a Gama-Ribeiro, Vasco $u Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia, Rua Conceicao Fernandes, 4434 502, Vila Nova de Gaia, Portugal.
- 700 1_
- $a Benedek, Imre $u Department of Cardiology, Cardio Med Medical Center, 22 decembrie 1989, 540156, Targu-Mures, Romania.
- 700 1_
- $a Benedek, Teodora $u Department of Cardiology, Cardio Med Medical Center, 22 decembrie 1989, 540156, Targu-Mures, Romania.
- 700 1_
- $a Adjić, Filip $u Radiology Department Imaging Center, Institute of Cardiovascular Diseases of Vojvodina, Put dr Goldmana 4, Sremska Kamenica, Novi Sad, 212014, Serbia.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Kepka, Cezary $u Department of Radiology, The Institute of Cardiology in Warsaw, Ul. Alpejska 42, 04-628, Warsaw, Poland.
- 700 1_
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