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Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study
H. Gensicke, JW. Evans, FS. Al Ajlan, D. Dowlatshahi, M. Najm, AL. Calleja, J. Puig, SL. Sohn, SH. Ahn, AY. Poppe, R. Mikulik, N. Asdaghi, TS. Field, A. Jin, T. Asil, JM. Boulanger, MD. Hill, M. Goyal, AM. Demchuk, BK. Menon, INTERRSeCT Investigators,
Jazyk angličtina Země Německo
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie
Grantová podpora
P300PB_161071
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
NLK
ProQuest Central
od 2002-01-01 do Před 1 rokem
CINAHL Plus with Full Text (EBSCOhost)
od 2008-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2002-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-01-01 do Před 1 rokem
- MeSH
- Bayesova věta MeSH
- CT angiografie metody MeSH
- fibrinolytika terapeutické užití MeSH
- intrakraniální trombóza diagnostické zobrazování farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- počítačová rentgenová tomografie metody MeSH
- prospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tkáňový aktivátor plazminogenu terapeutické užití MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- srovnávací studie MeSH
PURPOSE: To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. METHODS: Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (ΔHUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC). RESULTS: Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HUmax ≥ 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HUmax > 89 vs. 16.8% (95%CI 13.0-20.6) when HUmax ≤ 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8). CONCLUSION: Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.
Bezmialem Vakif Univesitesi Noroloji Istanbul Turkey
Centre Hospitalier de l'Université de Montréal University of Montréal Montreal Québec Canada
Charles LeMoyne Hospital University of Sherbrooke Greenfield Park Canada
Department of Neurology Chosun University School of Medicine Gwangju Republic of Korea
Dr Josep Trueta University Hospital Girona Spain
Miller School of Medicine University of Miami Miami Florida USA
Queen's University Kingston Ontario Canada
Universidad de Valladolid Valladolid Spain
University of British Columbia Vancouver British Columbia Canada
Citace poskytuje Crossref.org
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- $a Gensicke, Henrik $u Calgary Stroke Program, Departments of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. henrik.gensicke@usb.ch. Stroke Center and Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. henrik.gensicke@usb.ch.
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- $a Comparison of different methods of thrombus permeability measurement and impact on recanalization in the INTERRSeCT multinational multicenter prospective cohort study / $c H. Gensicke, JW. Evans, FS. Al Ajlan, D. Dowlatshahi, M. Najm, AL. Calleja, J. Puig, SL. Sohn, SH. Ahn, AY. Poppe, R. Mikulik, N. Asdaghi, TS. Field, A. Jin, T. Asil, JM. Boulanger, MD. Hill, M. Goyal, AM. Demchuk, BK. Menon, INTERRSeCT Investigators,
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- $a PURPOSE: To compare the association of different measures of intracranial thrombus permeability on non-contrast computerized tomography (NCCT) and computed tomography angiography (CTA) with recanalization with or without intravenous alteplase. METHODS: Patients with anterior circulation occlusion from the INTERRSeCT study were included. Thrombus permeability was measured on non-contrast CT and CTA using the following methods: [1] automated method, mean attenuation increase on co-registered thin (< 2.5 mm) CTA/NCCT; [2] semi-automated method, maximum attenuation increase on non-registered CTA/NCCT (ΔHUmax); [3] manual method, maximum attenuation on CTA (HUmax); and [4] visual method, residual flow grade. Primary outcome was recanalization with intravenous alteplase on the revised AOL scale (2b/3). Regression models were compared using C-statistic, Akaike (AIC), and Bayesian information criterion (BIC). RESULTS: Four hundred eighty patients were included in this analysis. Statistical models using methods 2, 3, and 4 were similar in their ability to discriminate recanalizers from non-recanalizers (C-statistic 0.667, 0.683, and 0.634, respectively); method 3 had the least information loss (AIC = 483.8; BIC = 492.2). A HUmax ≥ 89 measured with method 3 provided optimal sensitivity and specificity in discriminating recanalizers from non-recanalizers [recanalization 55.4% (95%CI 46.2-64.6) when HUmax > 89 vs. 16.8% (95%CI 13.0-20.6) when HUmax ≤ 89]. In sensitivity analyses restricted to patients with co-registered CTA/NCCT (n = 88), methods 1-4 predicted recanalization similarly (C-statistic 0.641, 0.688, 0.640, 0.648, respectively) with Method 2 having the least information loss (AIC 104.8, BIC 109.8). CONCLUSION: Simple methods that measure thrombus permeability are as reliable as complex image processing methods in discriminating recanalizers from non-recanalizers.
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