Tissue Plasminogen Activator [tkáňový aktivátor plazminogenu]

topical
240
Terms

Actilyse
Activase
alteplasa
altepláza
plasminogen - aktivátor tkáňového typu
tisokináza
TTPA

 

Actilyse
Activase
Alteplase
Lysatec rt-PA
Plasminogen Activator, Tissue-Type
T-Plasminogen Activator
Tisokinase
Tissue Activator D-44
Tissue-Type Plasminogen Activator
TTPA

Persistent link   https://www.medvik.cz/link/D010959
Definition

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

DUI
D010959 MeSH Browser
CUI
M0016991
Previous indexing
Enzyme Activation (1974-1975); Peptide Hydrolases (1975); Plasminogen Activators (1976-1985)
History note
98(86)
Public note
98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91

Allowable subheadings

AD
administration & dosage 87
AE
adverse effects 30
AN
analysis 5
AI
antagonists & inhibitors 1
BI
biosynthesis 1
BL
blood 14
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency 1
DE
drug effects 2
EC
economics 1
GE
genetics
HI
history
IM
immunology 1
IP
isolation & purification 1
ME
metabolism 4
PK
pharmacokinetics 1
PD
pharmacology 12
PH
physiology 3
PO
poisoning
RE
radiation effects
ST
standards 1
SD
supply & distribution
TU
therapeutic use 149
TO
toxicity
UL
ultrastructure 1
UR
urine 1

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 554
D08.811.277 Hydrolases 475
D08.811.277.656 Peptide Hydrolases 560
D08.811.277.656.300 Endopeptidases 213
D08.811.277.656.300.760 Serine Endopeptidases 138
D08.811.277.656.300.760.030 Acrosin 14
D08.811.277.656.300.760.066 Cathepsin G 4
D08.811.277.656.300.760.103 Chymases 5
D08.811.277.656.300.760.176 Chymotrypsin 133
D08.811.277.656.300.760.198 Complement Factor B 3
D08.811.277.656.300.760.200 Complement Factor D 6
D08.811.277.656.300.760.210 Complement Factor I
D08.811.277.656.300.760.247 Endopeptidase K 7
D08.811.277.656.300.760.284 Enteropeptidase 3
D08.811.277.656.300.760.300 Factor VIIa 110
D08.811.277.656.300.760.310 Factor IXa 6
D08.811.277.656.300.760.315 Factor Xa 189
D08.811.277.656.300.760.320 Factor XIa 7
D08.811.277.656.300.760.324 Factor XIIa 2
D08.811.277.656.300.760.330 Fibrinolysin 44
D08.811.277.656.300.760.353 Furin 3
D08.811.277.656.300.760.397 Granzymes 11
D08.811.277.656.300.760.420 High-Temperature Requirement A Serine Peptidase 1 1
D08.811.277.656.300.760.431 High-Temperature Requirement A Serine Peptidase 2
D08.811.277.656.300.760.442 Kallikreins 40
D08.811.277.656.300.760.471 Lactoferrin 32
D08.811.277.656.300.760.501 Mannose-Binding Protein-Associated Serine Proteases 2
D08.811.277.656.300.760.530 Myeloblastin 8
D08.811.277.656.300.760.560 Pancreatic Elastase 93
D08.811.277.656.300.760.635 Plasminogen Activators 56
D08.811.277.656.300.760.637 Prolyl Oligopeptidases 3
D08.811.277.656.300.760.638 Pronase 4
D08.811.277.656.300.760.640 Proprotein Convertase 1 4
D08.811.277.656.300.760.646 Proprotein Convertase 2
D08.811.277.656.300.760.648 Proprotein Convertase 5
D08.811.277.656.300.760.718 Proprotein Convertase 9 271
D08.811.277.656.300.760.753 Reelin Protein
D08.811.277.656.300.760.787 Subtilisins 7
D08.811.277.656.300.760.855 Thrombin 228
D08.811.277.656.300.760.875 Tissue Plasminogen Activator 240
D08.811.277.656.300.760.875.500 Tenecteplase 5
D08.811.277.656.300.760.895 Trypsin 257
D08.811.277.656.300.760.902 Tryptases 38
D08.811.277.656.300.760.910 Urokinase-Type Plasminogen Activator 61
D08.811.277.656.300.760.955 Venombin A 1
D08.811.277.656.959 Serine Proteases 21
D08.811.277.656.959.350 Serine Endopeptidases 138
D08.811.277.656.959.350.030 Acrosin 14
D08.811.277.656.959.350.066 Cathepsin G 4
D08.811.277.656.959.350.103 Chymases 5
D08.811.277.656.959.350.176 Chymotrypsin 133
D08.811.277.656.959.350.198 Complement Factor B 3
D08.811.277.656.959.350.200 Complement Factor D 6
D08.811.277.656.959.350.210 Complement Factor I
D08.811.277.656.959.350.247 Endopeptidase K 7
D08.811.277.656.959.350.284 Enteropeptidase 3
D08.811.277.656.959.350.300 Factor VIIa 110
D08.811.277.656.959.350.310 Factor IXa 6
D08.811.277.656.959.350.315 Factor Xa 189
D08.811.277.656.959.350.320 Factor XIa 7
D08.811.277.656.959.350.324 Factor XIIa 2
D08.811.277.656.959.350.330 Fibrinolysin 44
D08.811.277.656.959.350.353 Furin 3
D08.811.277.656.959.350.397 Granzymes 11
D08.811.277.656.959.350.420 High-Temperature Requirement A Serine Peptidase 1 1
D08.811.277.656.959.350.431 High-Temperature Requirement A Serine Peptidase 2
D08.811.277.656.959.350.442 Kallikreins 40
D08.811.277.656.959.350.471 Lactoferrin 32
D08.811.277.656.959.350.501 Mannose-Binding Protein-Associated Serine Proteases 2
D08.811.277.656.959.350.530 Myeloblastin 8
D08.811.277.656.959.350.560 Pancreatic Elastase 93
D08.811.277.656.959.350.635 Plasminogen Activators 56
D08.811.277.656.959.350.638 Pronase 4
D08.811.277.656.959.350.640 Proprotein Convertase 1 4
D08.811.277.656.959.350.646 Proprotein Convertase 2
D08.811.277.656.959.350.648 Proprotein Convertase 5
D08.811.277.656.959.350.718 Proprotein Convertase 9 271
D08.811.277.656.959.350.753 Reelin Protein
D08.811.277.656.959.350.787 Subtilisins 7
D08.811.277.656.959.350.855 Thrombin 228
D08.811.277.656.959.350.875 Tissue Plasminogen Activator 240
D08.811.277.656.959.350.875.500 Tenecteplase 5
D08.811.277.656.959.350.895 Trypsin 257
D08.811.277.656.959.350.902 Tryptases 38
D08.811.277.656.959.350.910 Urokinase-Type Plasminogen Activator 61
D08.811.277.656.959.350.955 Venombin A 1
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 584
D12.776.124 Blood Proteins 910
D12.776.124.125 Blood Coagulation Factors 333
D12.776.124.125.662 Plasminogen Activators 56
D12.776.124.125.662.537 Streptokinase 209
D12.776.124.125.662.768 Tissue Plasminogen Activator 240
D12.776.124.125.662.768.500 Tenecteplase 5
D12.776.124.125.662.884 Urokinase-Type Plasminogen Activator 61
D23 Biological Factors 143
D23.119 Blood Coagulation Factors 333
D23.119.050 beta-Thromboglobulin 7
D23.119.100 Calcium 2 844
D23.119.300 Factor V 94
D23.119.325 Factor VII 55
D23.119.350 Factor VIII 315
D23.119.375 Factor IX 83
D23.119.400 Factor X 36
D23.119.425 Factor XI 5
D23.119.450 Factor XII 18
D23.119.475 Factor XIII 14
D23.119.490 Fibrinogen 486
D23.119.500 Fibrinopeptide A 9
D23.119.510 Fibrinopeptide B 6
D23.119.597 Kallikreins 40
D23.119.630 Kininogens 7
D23.119.832 Plasminogen Inactivators 14
D23.119.865 Platelet Activating Factor 32
D23.119.932 Platelet Factor 3 4
D23.119.940 Platelet Factor 4 18
D23.119.945 Prothrombin 116
D23.119.960 Thrombin 228
D23.119.965 Thromboplastin 57
D23.119.970 Tissue Plasminogen Activator 240
D23.119.985 von Willebrand Factor 132

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