Platelet Factor 4 [trombocytový faktor 4]

topical
18
Terms

Antiheparin Factor
Chemokine CXCL4
CXCL4 Chemokine
gamma-Thromboglobulin
Heparin Neutralizing Protein
PF4 (Platelet Factor 4)

Persistent link   https://www.medvik.cz/link/D010978
Definition

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

DUI
D010978 MeSH Browser
CUI
M0017019
CAS
Blood platelet factor 4
Previous indexing
Blood Coagulation Factors (1973-1975); Blood Platelets (1974-1975); Glycoproteins (1974-1975)
History note
84(76); was see under BLOOD COAGULATION FACTORS 1976-83
Public note
84; was see under BLOOD COAGULATION FACTORS 1976-83

Allowable subheadings

AD
administration & dosage
AE
adverse effects 3
AG
agonists
AN
analysis 2
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood 2
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 2
CL
classification
DF
deficiency
DE
drug effects 2
EC
economics
GE
genetics
HI
history
IM
immunology 2
IP
isolation & purification
ME
metabolism 2
PK
pharmacokinetics
PD
pharmacology
PH
physiology 2
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.644 Peptides 1 383
D12.644.276 Intercellular Signaling Peptides and Proteins 156
D12.644.276.374 Cytokines 2 161
D12.644.276.374.200 Chemokines 172
D12.644.276.374.200.120 Chemokines, CXC 8
D12.644.276.374.200.120.050 Chemokine CXCL1 7
D12.644.276.374.200.120.075 Chemokine CXCL16 1
D12.644.276.374.200.120.100 Chemokine CXCL2 5
D12.644.276.374.200.120.250 Chemokine CXCL5 5
D12.644.276.374.200.120.300 Chemokine CXCL6 1
D12.644.276.374.200.120.450 Chemokine CXCL9 2
D12.644.276.374.200.120.500 Chemokine CXCL10 11
D12.644.276.374.200.120.550 Chemokine CXCL11 2
D12.644.276.374.200.120.600 Chemokine CXCL12 24
D12.644.276.374.200.120.650 Chemokine CXCL13 11
D12.644.276.374.200.120.800 Interleukin-8 122
D12.644.276.374.200.120.900 Platelet Factor 4 18
D12.776 Proteins 2 579
D12.776.124 Blood Proteins 909
D12.776.124.125 Blood Coagulation Factors 332
D12.776.124.125.050 beta-Thromboglobulin 7
D12.776.124.125.300 Factor V 94
D12.776.124.125.325 Factor VII 55
D12.776.124.125.350 Factor VIII 311
D12.776.124.125.375 Factor IX 82
D12.776.124.125.400 Factor X 36
D12.776.124.125.425 Factor XI 5
D12.776.124.125.450 Factor XII 18
D12.776.124.125.475 Factor XIII 14
D12.776.124.125.500 Fibrinogen 485
D12.776.124.125.515 Fibrinopeptide A 9
D12.776.124.125.530 Fibrinopeptide B 6
D12.776.124.125.597 Kallikreins 39
D12.776.124.125.635 Kininogens 7
D12.776.124.125.640 Plasminogen Activator Inhibitor 1 74
D12.776.124.125.645 Plasminogen Activator Inhibitor 2 5
D12.776.124.125.662 Plasminogen Activators 56
D12.776.124.125.691 Platelet Factor 3 4
D12.776.124.125.720 Platelet Factor 4 18
D12.776.124.125.800 Prothrombin 116
D12.776.124.125.890 Thrombin 228
D12.776.124.125.900 Thromboplastin 57
D12.776.124.125.920 von Willebrand Factor 131
D12.776.467 Intercellular Signaling Peptides and Proteins 156
D12.776.467.374 Cytokines 2 161
D12.776.467.374.200 Chemokines 172
D12.776.467.374.200.120 Chemokines, CXC 8
D12.776.467.374.200.120.050 Chemokine CXCL1 7
D12.776.467.374.200.120.075 Chemokine CXCL16 1
D12.776.467.374.200.120.100 Chemokine CXCL2 5
D12.776.467.374.200.120.250 Chemokine CXCL5 5
D12.776.467.374.200.120.300 Chemokine CXCL6 1
D12.776.467.374.200.120.450 Chemokine CXCL9 2
D12.776.467.374.200.120.500 Chemokine CXCL10 11
D12.776.467.374.200.120.550 Chemokine CXCL11 2
D12.776.467.374.200.120.600 Chemokine CXCL12 24
D12.776.467.374.200.120.650 Chemokine CXCL13 11
D12.776.467.374.200.120.800 Interleukin-8 122
D12.776.467.374.200.120.900 Platelet Factor 4 18
D23 Biological Factors 143
D23.119 Blood Coagulation Factors 332
D23.119.050 beta-Thromboglobulin 7
D23.119.100 Calcium 2 832
D23.119.300 Factor V 94
D23.119.325 Factor VII 55
D23.119.350 Factor VIII 311
D23.119.375 Factor IX 82
D23.119.400 Factor X 36
D23.119.425 Factor XI 5
D23.119.450 Factor XII 18
D23.119.475 Factor XIII 14
D23.119.490 Fibrinogen 485
D23.119.500 Fibrinopeptide A 9
D23.119.510 Fibrinopeptide B 6
D23.119.597 Kallikreins 39
D23.119.630 Kininogens 7
D23.119.832 Plasminogen Inactivators 14
D23.119.865 Platelet Activating Factor 32
D23.119.932 Platelet Factor 3 4
D23.119.940 Platelet Factor 4 18
D23.119.945 Prothrombin 116
D23.119.960 Thrombin 228
D23.119.965 Thromboplastin 57
D23.119.970 Tissue Plasminogen Activator 238
D23.119.985 von Willebrand Factor 131
D23.125 Chemotactic Factors 14
D23.125.300 Chemokines 172
D23.125.300.120 Chemokines, CXC 8
D23.125.300.120.050 Chemokine CXCL1 7
D23.125.300.120.075 Chemokine CXCL16 1
D23.125.300.120.100 Chemokine CXCL2 5
D23.125.300.120.250 Chemokine CXCL5 5
D23.125.300.120.300 Chemokine CXCL6 1
D23.125.300.120.450 Chemokine CXCL9 2
D23.125.300.120.500 Chemokine CXCL10 11
D23.125.300.120.550 Chemokine CXCL11 2
D23.125.300.120.600 Chemokine CXCL12 24
D23.125.300.120.650 Chemokine CXCL13 11
D23.125.300.120.800 Interleukin-8 122
D23.125.300.120.900 Platelet Factor 4 18
D23.469 Inflammation Mediators 325
D23.469.200 Chemokines 172
D23.469.200.120 Chemokines, CXC 8
D23.469.200.120.050 Chemokine CXCL1 7
D23.469.200.120.075 Chemokine CXCL16 1
D23.469.200.120.100 Chemokine CXCL2 5
D23.469.200.120.250 Chemokine CXCL5 5
D23.469.200.120.300 Chemokine CXCL6 1
D23.469.200.120.450 Chemokine CXCL9 2
D23.469.200.120.500 Chemokine CXCL10 11
D23.469.200.120.550 Chemokine CXCL11 2
D23.469.200.120.600 Chemokine CXCL12 24
D23.469.200.120.650 Chemokine CXCL13 11
D23.469.200.120.800 Interleukin-8 122
D23.469.200.120.900 Platelet Factor 4 18
D23.529 Intercellular Signaling Peptides and Proteins 156
D23.529.374 Cytokines 2 161
D23.529.374.200 Chemokines 172
D23.529.374.200.120 Chemokines, CXC 8
D23.529.374.200.120.050 Chemokine CXCL1 7
D23.529.374.200.120.075 Chemokine CXCL16 1
D23.529.374.200.120.100 Chemokine CXCL2 5
D23.529.374.200.120.250 Chemokine CXCL5 5
D23.529.374.200.120.300 Chemokine CXCL6 1
D23.529.374.200.120.450 Chemokine CXCL9 2
D23.529.374.200.120.500 Chemokine CXCL10 11
D23.529.374.200.120.550 Chemokine CXCL11 2
D23.529.374.200.120.600 Chemokine CXCL12 24
D23.529.374.200.120.650 Chemokine CXCL13 11
D23.529.374.200.120.800 Interleukin-8 122
D23.529.374.200.120.900 Platelet Factor 4 18

PF4 protein, human Chemical MeSH Browser

PF4V1 protein, human Chemical MeSH Browser

Pf4 protein, mouse Chemical MeSH Browser

platelet factor 4 (47-70) Chemical MeSH Browser

platelet factor 4 (59-70) Chemical MeSH Browser

recombinant PF4-241 Chemical MeSH Browser

Add